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Links from GEO DataSets

Items: 20

1.

Influence of cyclical mechanical strain on global gene expression in human lamina cribrosa cells in vitro

(Submitter supplied) The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extra-cellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of the optic nerve head in POAG. Glial cells in the lamina cribrosa may play a role in this process but the precise cellular responses to mechanical forces in this region are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data
Series
Accession:
GSE3166
ID:
200003166
2.

TGF-beta regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells

(Submitter supplied) Primary open angle glaucoma (POAG) is a progressive optic neuropathy, which is a major cause of worldwide visual impairment and blindness. Pathological hallmarks of the glaucomatous optic nerve head include retinal ganglion cell axon loss and extracellular matrix (ECM) remodeling of the lamina cribrosa layer. TGF-beta is an important pro-fibrotic modulator of ECM metabolism, whose levels are elevated in human POAG lamina cribrosa tissue compared with non-glaucomatous controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1313
Platform:
GPL96
4 Samples
Download data
Series
Accession:
GSE2705
ID:
200002705
3.
Full record GDS1313

GFAP-negative lamina cribrosa cell response to TGF-beta1

Analysis of glial fibrillary acidic acid (GFAP)-negative lamina cribrosa (LC) glial cell response to 10 ng/ml TGF-beta1 for 24 hours. This is a model for primary open-angle glaucoma (POAG) in which TGF-beta levels are elevated in human LC tissue.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL96
Series:
GSE2705
4 Samples
Download data
DataSet
Accession:
GDS1313
ID:
1313
4.

Comparison between human normal and glaucomatous lamina cribrosa cells

(Submitter supplied) Purpose: Marked extracellular matrix (ECM) remodeling occurs in the human optic nerve head in primary open angle glaucoma (POAG). The glial fibrillary acid protein (GFAP) negative lamina cribrosa cell may play an important role in this remodeling process. The authors report the first study of global and ECM-focused gene transcription differentials between GFAP-negative negative lamina cribrosa (LC) cells from normal and POAG human donors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
4 Samples
Download data: CEL
Series
Accession:
GSE13534
ID:
200013534
5.

Expression data from GFAP-negative LC cells exposed to 24 hours of hypoxia

(Submitter supplied) Vascular hypoperfusion is a pathological phenomenon in the glaucomatous optic nerve head. We report transcriptional responses in GFAP-negative LC cells exposed to in-vitro hypoxic stress (1%O2).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
6 Samples
Download data: CEL
Series
Accession:
GSE26820
ID:
200026820
6.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
7.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
8.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4564
9 Samples
Download data
Series
Accession:
GSE6298
ID:
200006298
9.

Gene expression in human optic nerve head (ONH) astrocytes

(Submitter supplied) Gene expression in human optic nerve head (ONH) astrocytes exposed to either 60 mm Hg hydrostatic pressure (HP) or control ambient pressure (CP) was compared using Affymetrix GeneChip microarrays to identify HP-responsive genes. Primary ONH astrocytes from two male Caucasian donors (passage 4) were grown to 75% confluence and were exposed for 6, 24 or 48 h to control ambient pressure (CP6, CP24, CP48) or hydrostatic pressure (HP6, HP24, HP48), or harvested at the beginning of the pressure experiment (CP0). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS532
Platform:
GPL8300
44 Samples
Download data
Series
Accession:
GSE758
ID:
200000758
10.
Full record GDS532

Hydrostatic pressure-responsive genes in optic nerve head astrocytes

Temporal analysis of how astrocytes in the optic nerve head (ONH) respond to changes in intraocular pressure (IOP). ONH astrocytes exposed to 60 mm Hg hydrostatic pressure for 6, 24, and 48 hours. Lends understanding to pathogenesis of glaucoma.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol, 4 time sets
Platform:
GPL8300
Series:
GSE758
44 Samples
Download data
11.

Comparative gene expression profile analysis between native human odontoblasts and pulp tissue

(Submitter supplied) Knowledge of differential gene expression between pulp and odontoblasts might give insight to the regulation of these spatially related but functionally diverse cells. Our aim was large-scale analysis of expression profiles of native human pulp tissue and odontoblasts, and search for genes expressed only in odontoblasts. Keywords: comparative expression analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL96
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE8694
ID:
200008694
12.

The Influence of Interferon Gamma on Gene Expression in Normal Human Bronchial Epithelial Cells

(Submitter supplied) RNA from cultured human bronchial epithelial cells treated for 8 hours or for 24 hours with medium alone, interferon gamma, dexamethasone or both interferon gamma and dexamethasone. Keywords = interferon gamma Keywords = dexamethasone Keywords = human bronchial epithelial cells Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1256
Platform:
GPL8300
36 Samples
Download data
Series
Accession:
GSE1815
ID:
200001815
13.
Full record GDS1256

IFN-gamma inflammatory effect on bronchial epithelial cells modulated by dexamethasone: time course

Analysis of bronchial epithelial cells treated with interferon (IFN) gamma, or dexamethasone (dex), or both. IFN-gamma plays a role in lung inflammatory responses and corticosteroids such as dex are used as treatments for inflammation. Cells examined 8 or 24 hours after treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent, 2 time sets
Platform:
GPL8300
Series:
GSE1815
36 Samples
Download data
DataSet
Accession:
GDS1256
ID:
1256
14.

mouse corneal stromal cells

(Submitter supplied) To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea. Keywords = corneal stroma maturation keratocyte fibroblast myofibroblast TGF beta 1 Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS857
Platform:
GPL81
14 Samples
Download data: CEL
Series
Accession:
GSE1867
ID:
200001867
15.
Full record GDS857

Corneal stromal cell differentiation

Expression profiling of cultured keratocyte, fibroblast, and myofibroblast cells of the corneal stroma. Cultured cells compared to cornea from adults and 10 day postnatals. Keratocytes maintain the transparent corneal stroma, and upon injury differentiate into fibroblasts and myofibroblasts.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 cell type, 3 protocol sets
Platform:
GPL81
Series:
GSE1867
14 Samples
Download data: CEL
DataSet
Accession:
GDS857
ID:
857
16.

Transcriptome-wide characterization of gene expression associated with unruptured intracranial aneurysms

(Submitter supplied) The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3903
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE26969
ID:
200026969
17.
Full record GDS3903

Unruptured intracranial arterial aneurysm: cerebral artery

Analysis of unruptured intracranial arterial aneurysm (IAA). IAA is a cerebrovascular disorder in which weakness in a cerebral artery wall causes localized dilation and possible rupture. Results provide insight into the molecular mechanisms underlying cerebral aneurysms.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE26969
6 Samples
Download data: CEL
18.

Microarray analysis of changes in gene expression within the amacrine cell layer of chicks following optical defocus

(Submitter supplied) Ocular growth is regulated locally by signals produced in the retina that ultimately act on the growth of the scleral tissue. Consequently, a number of studies have investigated changes in retinal gene expression during manipulation of ocular growth in an attempt to elucidate the biochemical pathways underlying eye growth. However, due to the highly heterogenous nature of the retina, important changes in gene expression can be masked. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL3213
9 Samples
Download data: CEL
Series
Accession:
GSE17758
ID:
200017758
19.

Normal and glaucomatous astrocytes

(Submitter supplied) Astrocytes from optic nerve head from donors with and without glaucoma Keywords: parallel sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1112
Platforms:
GPL8300 GPL91
15 Samples
Download data: CEL, EXP
Series
Accession:
GSE2378
ID:
200002378
20.
Full record GDS1112

Glaucomatous astrocytes from the optic nerve head

Expression profiling of astrocytes taken from the optic nerve head (ONH) of patients with glaucoma. The ONH is the site of damage in glaucomatous optic neuropathy. Studies suggest that damage in glaucoma is mediated by reactive astrocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL8300
Series:
GSE2378
13 Samples
Download data: CEL, EXP
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