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Links from GEO DataSets

Items: 20

1.

Hepatoma cell lines vs. Universal control

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2911
18 Samples
Download data
Series
Accession:
GSE3444
ID:
200003444
2.

Hepatoma cell lines vs. Universal control 3

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2913
36 Samples
Download data
Series
Accession:
GSE3536
ID:
200003536
3.

Hepatoma cell lines vs. Universal control 2

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2912
18 Samples
Download data
Series
Accession:
GSE3511
ID:
200003511
4.

Human ovarian tumors and normal ovaries

(Submitter supplied) 99 individual ovarian tumors (37 endometrioid, 41 serous, 13 mucinous, and 8 clear cell carcinomas) and 4 individual normal ovary samples, each assayed on an Affymetrix HG_U133A array Keywords: Individual tumor comparisons
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
103 Samples
Download data: CEL
Series
Accession:
GSE6008
ID:
200006008
5.

Mouse model of Endometrioid Ovarian Adenocarcinomas by conditional inactivation of PTEN and APC genes

(Submitter supplied) Fifty million plaque-forming units of AdCre was injected into the right ovarian bursal cavity of 56- 70 day old female mice. Mice were euthanized 63 days later to obtain ovary tumors and normal ovary tissue. Seven individual ovarian tumors and 4 individual normal ovary samples were each assayed on an Affymetrix Mouse Genome 430 2.0 array. Keywords: Tumor vs normal comparisons
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
11 Samples
Download data: CEL
Series
Accession:
GSE5987
ID:
200005987
6.

Expression changes in intestinal crypts upon deletion of beta-catenin

(Submitter supplied) The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. β Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene expression by interacting with transcription factors of the TCF/LEF-family. In the present study we investigate the role of Wnt signaling in the homeostasis of intestinal epithelium using tissue-specific, inducible beta-catenin gene ablation in adult mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2984
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE8818
ID:
200008818
7.
Full record GDS2984

Beta-catenin inactivation effect on intestinal crypts

Analysis of intestinal crypts following inactivation of beta catenin. The mucosa of the intestine is composed of submucosal invaginations called intestinal crypts. Results provide insight into the molecular mechanisms underlying crypt loss as a result of beta-catenin inactivation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL1261
Series:
GSE8818
4 Samples
Download data: CEL, CHP
8.

Gene expression profiling of human mammary artery media during aging

(Submitter supplied) Our goal was to better understand the genes and pathways implicated during arterial media aging. We therefore compared the gene expression profile of human mammary artery media between Young (<60, 8 patients) and old (>75, 7 patients) patients. The microarray data, generated using the Illumina sentrix Ref8-V2 platform, was normalized and analyzed using the IlluminaGUI package (Eggle and Schultze, 2007).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6104
15 Samples
Download data: TXT
Series
Accession:
GSE16487
ID:
200016487
9.

Expression profile of conditional knock out of beta-catenin by K19-CRE at E7.5

(Submitter supplied) expression profile of conditional knock out of beta-catenin by K19-CRE at E7.5. Tested a wild type with two alleles of beta-catenin, a heterzyote with one deleted allele and the conditional null in the domain on cytokeratin 19 driven CRE expression Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL83 GPL81 GPL82
9 Samples
Download data: CEL, EXP
Series
Accession:
GSE2519
ID:
200002519
10.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL4125 GPL4124
8 Samples
Download data: TXT
Series
Accession:
GSE17733
ID:
200017733
11.

Comparison of TCF hyper-activated and control Huh7 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by SAGE
Platforms:
GPL570 GPL4
8 Samples
Download data: CEL, TAR
Series
Accession:
GSE11956
ID:
200011956
12.

Targets of Wnt-1 in C57MG

(Submitter supplied) RNA from murine mammary C57MG cells transfected with an empty control vector (PLNCx) or an expression vector encoding Wnt-1 was isolated and analyzed on Affymetrix MG-U74Av2 arrays. Sample preparation was done as recommended by the manufacturer. Images were analyzed using Affymetrix Microarray Suite 4.0 software. Comparison of Wnt-1 expressing and control cells revealed Wnt-1 targets. Keywords: ordered
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
2 Samples
Download data
Series
Accession:
GSE1899
ID:
200001899
13.

Effect of iron chelators on global gene expression pattern in SW480 cells

(Submitter supplied) Gene expression analysis of SW480 cells treated with inhibitor compounds for 6 hours. Results provide insights into the role of iron in Wnt signalling and demonstrate that iron depletion is the primary mode of actions of these compounds on Wnt pathway.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
13 Samples
Download data: CEL
Series
Accession:
GSE32369
ID:
200032369
14.

Gene expression analysis in human colon cancer cells and liver cancer cells with FoxA knockdown.

(Submitter supplied) FoxA transcription factors are involved in development and tumorigenesis of the gastrointestinal tract. However, the downstream programs controlled by FoxA factors remain poorly understood. The goal of this study is to understand the transcriptional responses regulated by FoxA proteins in liver and colon cancer cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
12 Samples
Download data: CEL
Series
Accession:
GSE46466
ID:
200046466
15.

Transcriptional responses of human colon and liver cancer cells to TCF inhibition.

(Submitter supplied) Dysregulation of Wnt/TCF signaling is closely associated with cancers arising from the gastrointestinal tract, inlcluding colon cancer and liver cancer. The goal of this study is to understand the transcriptional programs underlying Wnt/TCF activation in gastrointestinal cancers. We examined the transcriptional responses to TCF inhibition in cultured human colon cancer cells and liver cancer cells that are characteristic of Wnt pathway activation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
14 Samples
Download data: CEL
Series
Accession:
GSE46465
ID:
200046465
16.

β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling

(Submitter supplied) To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with β-catenin siRNA and identified β-catenin target genes using DNA microarrays. The list of identified target genes was compared to previously published β-catenin target genes found in the PubMed and the GEO databases. Based on the large number of β-catenin target genes found to be similarly regulated in DLD1, SW480 and LS174T as well as the large overlap with confirmed β-catenin target genes, we conclude that DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study β-catenin regulated genes and signaling pathways
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE44097
ID:
200044097
17.

Human HAK-1A hepatocellular carcinoma (HCC) cells: TCF-4J-overexpressing clone (under normoxia) vs. TCF-4K-overexpressing clone (under normoxia)

(Submitter supplied) The microarray gene expression analysis revealed that TCF-4 isoforms activate different downstream target genes in HCC. TCF-4J upregulated genes associated with Wnt/beta-catenin, Notch, and insulin/IGF-1/IRS1 signal transduction pathway.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
6 Samples
Download data: TXT
Series
Accession:
GSE42512
ID:
200042512
18.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma (HT-HG_U133A)

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4269
Platform:
GPL3921
4 Samples
Download data: CEL
Series
Accession:
GSE10393
ID:
200010393
19.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
118 Samples
Download data: TXT
Series
Accession:
GSE10186
ID:
200010186
20.
Full record GDS4269

Transforming growth factor-beta effect on Hepatocellular carcinoma Huh-7 cell line

Analysis of Hepatocellular carcinoma (HCC) Huh-7 cells stimulated with transforming growth factor-beta (TGF-β). HCC cell line Huh-7 has intact WNT pathway components. Results provide insight into the role of TGF-β in regulating WNT pathway activity in HCC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL3921
Series:
GSE10393
4 Samples
Download data: CEL
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