Similar studies for GEO DataSets (Select 200003952) - GEO DataSets

Select item 2000039521.

Organ - specific expression profiles of rat treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide

(Submitter supplied) A rexinoid, targretin (TRG) and two retinoids, 9-cis retinoic acid (9cRA) and 4-hydroxyphenylretinamide (4HPR) were examined for their effects on gene expression in rat mammary gland, liver, and lung tissues. The chemopreventive effects of these agents have largely been attributed to their ability to interact with retinoic acid receptors (RAR) and/or retinoid X-receptors (RXR). TRG interacts with the RXR receptors. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2385
Platform:: GPL85
43 Samples

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Series

Accession:: GSE3952

ID:: 200003952

Select item 23852.

Targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide effect on various organs

Analysis of normal livers, lungs, and mammary glands from Sprague Dawleys treated with targretin (TGR), 9-cis retinoic acid (9cRA), or 4-hydroxyphenylretinamide (4HPR). Results provide insight into the molecular basis of the varying chemopreventive anti-cancer effects of these agents.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 4 agent, 3 tissue sets

Platform:: GPL85
Series:: GSE3952
43 Samples

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DataSet

Accession:: GDS2385

ID:: 2385

Select item 2000576383.

Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin

(Submitter supplied) Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-methyl-UAB30 (4-Me-UAB30)] showed that all inhibited mammary cancer in rodents and two (TRG and 4-Me-UAB30) strikingly increased serum triglyceride levels. Agents were administered in diets to female Sprague-Dawley rats. Liver RNA was isolated and microarrayed on the Affymetrix GeneChip Rat Exon 1.0 ST array. Statistical tests identified genes that exhibited differential expression and fell into groups, or modules, with differential expression among agonists. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6194
16 Samples

Download data: CEL

Series

Accession:: GSE57638

ID:: 200057638

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001993814.

Connecting ligand-induced retinoid X receptor structural dynamics to rexinoid agonist potency

(Submitter supplied) Retinoid X receptors (RXR) are nuclear transcription factors that partner with other nuclear receptors to regulate numerous physiological processes. Although RXR represents a valid therapeutic target, only a few RXR-specific ligands (rexinoids) have been identified, in part due to the lack of clarity on how rexinoids selectively modulate RXR response. Previously, we showed that rexinoid UAB30 potentiates all-trans-retinoic acid (ATRA) signaling in human keratinocytes by stimulating ATRA biosynthesis. more...