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Links from GEO DataSets

Items: 4

1.

Organ - specific expression profiles of rat treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide

(Submitter supplied) A rexinoid, targretin (TRG) and two retinoids, 9-cis retinoic acid (9cRA) and 4-hydroxyphenylretinamide (4HPR) were examined for their effects on gene expression in rat mammary gland, liver, and lung tissues. The chemopreventive effects of these agents have largely been attributed to their ability to interact with retinoic acid receptors (RAR) and/or retinoid X-receptors (RXR). TRG interacts with the RXR receptors. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2385
Platform:
GPL85
43 Samples
Download data
Series
Accession:
GSE3952
ID:
200003952
2.
Full record GDS2385

Targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide effect on various organs

Analysis of normal livers, lungs, and mammary glands from Sprague Dawleys treated with targretin (TGR), 9-cis retinoic acid (9cRA), or 4-hydroxyphenylretinamide (4HPR). Results provide insight into the molecular basis of the varying chemopreventive anti-cancer effects of these agents.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 agent, 3 tissue sets
Platform:
GPL85
Series:
GSE3952
43 Samples
Download data
DataSet
Accession:
GDS2385
ID:
2385
3.

Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin

(Submitter supplied) Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-methyl-UAB30 (4-Me-UAB30)] showed that all inhibited mammary cancer in rodents and two (TRG and 4-Me-UAB30) strikingly increased serum triglyceride levels. Agents were administered in diets to female Sprague-Dawley rats. Liver RNA was isolated and microarrayed on the Affymetrix GeneChip Rat Exon 1.0 ST array. Statistical tests identified genes that exhibited differential expression and fell into groups, or modules, with differential expression among agonists. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6194
16 Samples
Download data: CEL
Series
Accession:
GSE57638
ID:
200057638
4.

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

(Submitter supplied) High throughput massively parallel sequencing on mRNA libraries generated from cortices of bexarotene or vehicle treated APP/PS1
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: TXT
Series
Accession:
GSE77569
ID:
200077569
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