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Links from GEO DataSets

Items: 17

1.

Limbal and Central Corneal Epithelia

(Submitter supplied) Limbal and central regoins of the rat cornea epithelium were used to constract 2 SAGE libraries, in order to identify candidate genes to distinguish stem cell from differentiated central cornea epithelium cells. Keywords: gene expression SAGE-based, count
Organism:
Rattus norvegicus
Type:
Expression profiling by SAGE
Platform:
GPL23
2 Samples
Download data
Series
Accession:
GSE4121
ID:
200004121
2.

Comparative transcriptional profiling of Limbal Epithelial Crypts with rest of the ocular surface epithelial regions.

(Submitter supplied) Recently we had discovered a solid cord like structure at the limbus of human eyes, termed as the Limbal Epithelial Crypt (LEC). It arises from the undersurface of the interpalisade rete ridges and extends towards the conjunctiva over the conjunctival stroma. Anatomical and immunohistochemical studies have shown it to be potentially a Stem Cell Niche. To confirm this hypothesis we conducted comparative gene expression profile of LEC with pathway and Geneontology studies in comparison with other ocular surface epithelial regions such as cornea, limbus, LEC stroma and conjunctiva. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9677
18 Samples
Download data: GPR
Series
Accession:
GSE19035
ID:
200019035
3.

Mouse limbal epithelial basal cells vs. corneal epithelial basal cell gene expression profile

(Submitter supplied) Limbal vs. corneal epithelial basal cell gene expression patterns were identified and compared Keywords: repeat
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2433
Platform:
GPL1261
16 Samples
Download data: CEL, EXP
Series
Accession:
GSE4098
ID:
200004098
4.
Full record GDS2433

Limbal and central corneal epithelial basal cell comparison

Analysis of microdissected resting limbal epithelial basal cells (LE) and central corneal epithelial (CE) basal cells of the eye. LE are enriched in corneal epithelial stem cells, CE in transient amplifying cells. Results provide insight into the molecular nature of the two basal cell populations.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 8 individual, 2 tissue sets
Platform:
GPL1261
Series:
GSE4098
16 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS2433
ID:
2433
5.

Corneal Gene Expression Analysis

(Submitter supplied) Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was to identify transcriptional gene profiles specific to AMLE and donor central corneal epithelium (CE), which may contribute to the divergent clinical outcomes observed following transplant. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5366
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE56421
ID:
200056421
6.
Full record GDS5366

Cultivated amniotic membrane expanded limbal epithelium

Analysis of amniotic membrane-expanded limbal epithelium (AMLE) and corneal epithelium (CE). AMLE transplantation in place of donor CE significantly improves outcome in severe limbal stem cell deficiency cases. Results provide insight into molecular processes which characterize AMLE and CE tissues.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 growth protocol, 2 tissue sets
Platform:
GPL6244
Series:
GSE56421
6 Samples
Download data: CEL
DataSet
Accession:
GDS5366
ID:
5366
7.

mRNA sequencing of Aniridia limbal epithelial cells.

(Submitter supplied) PAX6-related Aniridia is a sight-threatening disease due to progression of secondary glaucoma and aniridia associated keratopathy (AAK). Changes or loss of limbal epithelial progenitors causes the epithelial surfaces defects. We analyzed how PAX6 contribute to this with a two-step approach. 1) mRNA Sequencing of limbal epithelial cells isolated from controls and aniridia patients. 2) confirming the bioinformatical and literature-based result list on a siRNA based primary aniridia cell model (PAX6- knockdown). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: BW
Series
Accession:
GSE113008
ID:
200113008
8.

Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population in cornea

(Submitter supplied) Purpose: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice. Results: Unbiased clustering detected 10 distinct populations: three clusters of mesenchymal and seven clusters of epithelial cells, based on their unique molecular signatures. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: CLOUPE, MTX, TSV
Series
Accession:
GSE158454
ID:
200158454
9.

MicroRNA-145 Regulates Human Corneal Epithelial Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6480 GPL9081
10 Samples
Download data: TXT
Series
Accession:
GSE24981
ID:
200024981
10.

MicroRNA-145 Regulates Human Corneal Epithelial Differentiation [Agilent-014850 array data]

(Submitter supplied) To investigate the gene expression in human corneal epithelial overexpressing hsa-miR-145 by transfection , we have employed Whole Human Genome Oligo Microarray (Agilent) as a screening platform to identify gene regulation. We discovered a differential gene expression in HCE cells transfected with hsa-mIR-145 against cells with scrambled sequences. Among them, genes related with corneal development, integrity, differentiation and inflammatory responses were found and this was validated by real-time PCR.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
2 Samples
Download data: TXT
Series
Accession:
GSE24980
ID:
200024980
11.

MicroRNA-145 Regulates Human Corneal Epithelial Differentiation [Agilent-016436 array data]

(Submitter supplied) To investigate the microRNA expression in human limbal-peripheral corneal (LPC) epithelia containing corneal epithelial progenitor cells (CEPCs) and early transit amplifying cells, we have employed Human microRNA Microarray V2 (Agilent) as a screening platform to identify specific microRNAs. We discovered a differential expression of 18 microRNAs against central corneal (CC) epithelia, which contains late transit amplifying cells and terminally differentiated cells. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL9081
8 Samples
Download data: TXT
Series
Accession:
GSE24979
ID:
200024979
12.

Mus musculus cornea experiment

(Submitter supplied) PURPOSE: To provide a detailed gene expression profile of the normal postnatal mouse cornea. METHODS: Serial analysis of gene expression (SAGE) was performed on postnatal day (PN)9 and adult mouse (6 week) total corneas. The expression of selected genes was analyzed by in situ hybridization. RESULTS: A total of 64,272 PN9 and 62,206 adult tags were sequenced. Mouse corneal transcriptomes are composed of at least 19,544 and 18,509 unique mRNAs, respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platform:
GPL11
2 Samples
Download data
Series
Accession:
GSE887
ID:
200000887
13.

Rabbit limbal epithelial side population (SP) cells and non-SP cells

(Submitter supplied) Corneal epithelial stem cells reside in the limbus that is the transitional zone between the cornea and conjunctiva, and are essential to maintain the homeostasis of corneal epithelium. However, their characterization is poorly understood. Therefore, we constructed gene expression profiles of limbal epithelial SP and non-SP cell using RNA-sequencing. As a result, limbal epithelial SP cells have immature cell phenotypes with endothelial/mesenchymal cell markers, while limbal epithelial non-SP cells have epithelial progenitor cell markers.
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21655
8 Samples
Download data: TXT
Series
Accession:
GSE79620
ID:
200079620
14.

Gene Expression in Human Conjunctiva and Cornea

(Submitter supplied) PURPOSE. To determine global mRNA expression levels in the corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS. cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide array representing > 22,000 transcripts. The resulting signal intensities and transcript present/absent calls by the primary microarray analyzing software were used in conjunction with a statistical method to identify transcripts that are preferentially or exclusively (transcripts absent in all three replicates in the other tissue) and significantly (expression >1% of the ß-actin level) expressed in one of the two tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2682
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE5543
ID:
200005543
15.
Full record GDS2682

Conjunctiva and cornea comparison

Analysis of conjunctival (Cnj) and corneal (Co) epithelia, the main cellular components of the ocular surface. Cnj and Co epithelia are embryologically related but phenotypically and functionally disparate. Results provide insight into the molecular basis of these differences.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE5543
6 Samples
Download data
16.

Serial analysis of gene expression in the corneal endothelium of Fuchs' dystrophy

(Submitter supplied) PURPOSE: To compare the gene expression profiles of normal human corneal endothelium with Fuchs' corneal endothelium, by using serial analysis of gene expression (SAGE). METHODS: Three pairs of normal human corneas were obtained from eye banks. Thirteen bisected Fuchs' corneal buttons were processed at the time of corneal transplantation. The endothelia of normal and Fuchs'-affected corneas were stripped, and total RNA was isolated. more...
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL4
2 Samples
Download data
Series
Accession:
GSE505
ID:
200000505
17.

Transcriptional profiling of inductive prostatic mesenchyme

(Submitter supplied) Background: The mesenchymal compartment plays a key role in organogenesis and cells within the mesenchyme/stroma are a source of potent molecules that control epithelia during development and tumourigenesis. We have used Serial Analysis of Gene Expression (SAGE) to profile a key subset of prostatic mesenchyme that regulates prostate development and is enriched for growth-regulatory molecules. Results: SAGE libraries were made of prostatic inductive mesenchyme (VMP) and the complete prostatic rudiment (including inductive mesenchyme, epithelium and smooth muscle; VSU). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by SAGE
Platform:
GPL5330
2 Samples
Download data
Series
Accession:
GSE7899
ID:
200007899
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