Similar studies for GEO DataSets (Select 200004688) - GEO DataSets

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Items: 20

Select item 2000046881.

Molecular phenotype of G-CSF- or pegylated G-CSF-mobilized CD34+ cells

(Submitter supplied) Peripheral blood stem and progenitor cells (PBSC) are widely used for autologous and allogeneic hematopoietic stem cell transplantation. PBSC can be mobilized into the peripheral blood using cytokines, cytotoxic chemotherapy or a combination of both. Granulocyte colony stimulating factor (G-CSF) has become the most commonly administered cytokine for PBSC mobilization because of its high potency and lack of serious toxicity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2321
Platform:: GPL201
16 Samples

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Series

Accession:: GSE4688

ID:: 200004688

Select item 23212.

Polyethylene glycol-conjugated G-CSF mobilized CD34+ cells

Analysis of granulocyte colony stimulating factor (G-CSF) or polyethylene glycol-conjugated (pegylated) G-CSF mobilized CD34+ hematopoietic stem and progenitor cells from multiple myeloma patients undergoing chemotherapy. Pegylated G-CSF has a longer half-life than unconjugated G-CSF.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL201
Series:: GSE4688
16 Samples

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DataSet

Accession:: GDS2321

ID:: 2321

Select item 2000037883.

Lin-, CD38-, CD34+ Hematopoietic Stem Cells.

(Submitter supplied) Lin-, CD38-, CD34+ hematopoietic stem cells. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL97
6 Samples

Download data: CEL, EXP

Series

Accession:: GSE3788

ID:: 200003788

Select item 2000074004.

Hematopoietic stem cell mobilization with G-CSF (gene expression profiling)

(Submitter supplied) Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated based on gene microarray analysis. Ten peripheral blood samples from normal donors for allogeneic PBSC transplantation were obtained before and after administration of G-CSF and tested on Affymetrix Human U133 Plus 2.0 GeneChip® microarrays. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2959
Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE7400

ID:: 200007400

Select item 29595.

Granulocyte colony-stimulating factor mobilized leukocytes

Analysis of leukocytes from individuals before and after the administration of granulocyte colony-stimulating factor (G-CSF). G-CSF is used to boost granulocyte counts in immunocompromised patients. Results provide insight into the effect of G-CSF on the immune system.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 5 individual sets

Platform:: GPL570
Series:: GSE7400
10 Samples

Download data: CEL

DataSet

Accession:: GDS2959

ID:: 2959

Select item 2000080406.

CD34 antigen role in haematopoietic commitment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
6 Samples

Download data: CEL

Series

Accession:: GSE8040

ID:: 200008040

Select item 2000080037.

CD34 Overexpression

(Submitter supplied) In order to investigate the role of CD34 antigen in haematopoietic commitment, we overexpressed the human CD34 cDNA in human CD34+ cells by retroviral gene transfer. Keywords: treatment comparison

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
3 Samples

Download data: CEL

Series

Accession:: GSE8003

ID:: 200008003

Select item 2000080028.

CD34 gene silencing

(Submitter supplied) In order to investigate the role of CD34 antigen in haematopoietic commitment, we silenced the CD34 gene expression in CD34+ stem/progenitor cells using a siRNA approach. Keywords: treatment comparison

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
3 Samples

Download data: CEL

Series

Accession:: GSE8002

ID:: 200008002

Select item 2000014939.

Hematopoietic stem cell subsets

(Submitter supplied) Hematopoietic stem cell (HSC) subsets based on the CD34 expression and/or lineage markers expression Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1095
Platform:: GPL8300
6 Samples

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Series

Accession:: GSE1493

ID:: 200001493

Select item 109510.

Hematopoeitic stem cells of various types

Expression profiling of Lin-CD34-, Lin-CD34+, and Lin+CD34+ peripheral blood hematopoeitic stem cells (HSCs). Results provide insight into the molecular basis of the association of CD34 expression with self-renewal and lineage commitment in HSCs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 cell type sets

Platform:: GPL8300
Series:: GSE1493
6 Samples

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DataSet

Accession:: GDS1095

ID:: 1095

Select item 20000555011.

Molecular signature of CD34+ hematopoietic stem and progenitor cells in chronic phase CML

(Submitter supplied) Chronic myelogenous leukaemia (CML) is a malignant disorder of the hematopoietic stem cell, which is characterized by the reciprocal translocation between chromosomes 9 and 22 (t(9;22)(q34;q11)) The translocation results in the formation of the BCR-ABL fusion oncogene encoding a protein with constitutive activated tyrosine kinase activity which plays a central role in the pathogenesis of the disease. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2342
Platform:: GPL201
17 Samples

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Series

Accession:: GSE5550

ID:: 200005550

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 234212.

Chronic phase chronic myelogenous leukemia: CD34+ hematopoietic stem and progenitor cells

Analysis of CD34+ hematopoietic stem and progenitor cells from the bone marrow of untreated patients with chronic myelogenous leukemia (CML) in first chronic phase. Results provide insight into the pathogenesis of chronic phase CML.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 disease state sets

Platform:: GPL201
Series:: GSE5550
17 Samples

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DataSet

Accession:: GDS2342

ID:: 2342

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20000050013.

CD34+ cell analysis

(Submitter supplied) Comparison of gene expression in CD34+ cells from bone marrow and G-CSF-mobilized peripheral blood to investigate why the latter are optimal for allogeneic transplant recipients. Keywords: other

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS53
Platform:: GPL80
5 Samples

Download data: CEL

Series

Accession:: GSE500

ID:: 200000500

Select item 5314.

CD34+ cell analysis

Comparison of gene expression in CD34+ cells from bone marrow and G-CSF-mobilized peripheral blood to investigate why the latter are optimal for allogeneic transplant recipients.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type sets

Platform:: GPL80
Series:: GSE500
5 Samples

Download data: CEL

DataSet

Accession:: GDS53

ID:: 53

Select item 20000300315.

Gene expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix

(Submitter supplied) CD34+ hematopoietic stem/progenitor cells (HSC) reside in the bone marrow in close vicinity to the endosteal bone surface, surrounded by osteoblasts, stromal cells and various extracellular matrix molecules. We utilized a bioartificial matrix containing fibrillar collagen I, the major matrix component of bone, as scaffold for ex vivo expansion of HSCs. CD34+ HSCs were isolated from umbilical cord blood and cultivated within reconstituted collagen I fibrils in presence of FLT3-ligand, SCF and IL-3. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1401
Platform:: GPL96
6 Samples

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Series

Accession:: GSE3003

ID:: 200003003

Select item 140116.

CD34+ hematopoietic cells expanded in artificial matrix of fibrillar collagen I

Analysis of CD34+ hematopoietic stem/progenitor cells (HSC) expanded for 7 days in an artificial matrix of fibrillar collagen I, the major matrix component of bone. Results provide insight into the limitations of ex vivo expansion to increase the number of transplantable HSCs from cord blood.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 growth protocol sets

Platform:: GPL96
Series:: GSE3003
6 Samples

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DataSet

Accession:: GDS1401

ID:: 1401

Select item 20001693617.

AMD3100 and G-CSF Mobilize Different CD34+ Cell Populations Based on Gene and miRNA Expression

(Submitter supplied) Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF. CD34+ cells were isolated by immunoselection and were analyzed by global gene and micro RNA (miR) expression microarrays. more...

Organism:: Homo sapiens; human gammaherpesvirus 4; Betapolyomavirus macacae; Macaca mulatta; Mus musculus; Rattus norvegicus; Human gammaherpesvirus 8

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platforms:: GPL8793 GPL8794
36 Samples

Download data: GPR

Series

Accession:: GSE16936

ID:: 200016936

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000341018.

IM CD34+ progenitors cells

(Submitter supplied) IM CD34+ vs BM CD34+ cells Keywords: parallel sample

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2397
Platform:: GPL96
6 Samples

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Series

Accession:: GSE3410

ID:: 200003410

Select item 239719.

Idiopathic myelofibrosis: hematopoietic CD34+ stem cells

Analysis of pooled hematopoietic CD34+ stem cells from peripheral blood of patients with idiopathic myelofibrosis (IM), a rare chronic myeloproliferative disorder. Results provide insight into the molecular pathogenesis of IM.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE3410
6 Samples

Download data

DataSet

Accession:: GDS2397

ID:: 2397

Select item 20001125520.

Peripheral blood stem cell gene and microRNA profiling

(Submitter supplied) Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to compare AMD3100-mobilized CD133+ cells from 4 subjects, AMD3100 plus G-CSF-mobilized CD133+ cells from 4 subjects and G-CSF-mobilized CD34+ cells from 5 subjects. more...