GEO DataSets

(Submitter supplied) The FBP (FUSE Binding Protein) transcription factor family is composed of three highly related members; FBP/FBP1, FBP2, and FBP3. While they all share distinct modular protein structures and nucleic acid-binding specificities, their transactivator strength is graded and they also differ in their interaction with their protein partners. Especially from the extensive nuclear co-localization of these molecules, we anticipated that they co-regulate a set of common target genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2573

Platform:

GPL3779

6 Samples

Download data: GPR

Analysis of primary skin fibroblasts (Hs68) following siRNA knockdown of far-upstream element binding protein (FBP) 1, 2, or 3. Results provide insight into the function of each member of the FBP transactivator family.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 3 protocol sets

Platform:

GPL3779

Series:

GSE4914

6 Samples

Download data: GPR

(Submitter supplied) siRNA-mediated inhibition compared to untreated cells and cells transfected with nonsense siRNA Together with far upstream element binding protein (FBP), the FBP-interacting repressor (FIR) represents a molecular tool for the transcriptional fine tune regulation of target genes. Previous evidence indicates that strong overexpression of FBP in human hepatocellular carcinoma (HCC) supports tumor growth and correlates with poor patient prognosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17556

6 Samples

Download data: CEL

(Submitter supplied) JTV is not only a structural component of multi-aminoacyl-tRNA synthetase complex, but also a regulator of FBP that in turn controls c-Myc expression. In order to identify JTV target genes other than FBP and c-Myc, JTV or JTV-Alt (alternatively spliced form of JTV, enriched in the nucleus) protein was over-expressed in HeLa cells and global gene expression changes were monitored using cDNA expression microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3779

4 Samples

Download data: GPR