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Links from GEO DataSets

Items: 20

1.

Expression Data from Macrophage Maturation and Polarization Experiment

(Submitter supplied) Monocytes were induced to mature to macrophages with M-CSF. Cells were then activated with Interferon gamma and LPS or IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2429 GDS2430
Platforms:
GPL97 GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE5099
ID:
200005099
2.
Full record GDS2430

Monocyte differentiation to macrophage and subsequent polarization (HG-U133B)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL97
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2430
ID:
2430
3.
Full record GDS2429

Monocyte differentiation to macrophage and subsequent polarization (HG-U133A)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL96
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2429
ID:
2429
4.

CXCL4 induces a unique transcriptome in monocyte-derived macrophages

(Submitter supplied) Human blood monocytes were differentiated over six days with either 100 ng/ml M-CSF or 1 umol/l CXCL4 In atherosclerotic arteries, blood monocytes differentiate to macrophages in the presence of growth factors like macrophage colony-stimulation factor (MCSF) and chemokines like platelet factor 4 (CXCL4). To compare the gene expression signature of CXCL4-induced macrophages with MCSF-induced macrophages or macrophages polarized with IFN-γ/LPS (M1) or IL-4 (M2), we cultured primary human peripheral blood monocytes for six days. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3787
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE20484
ID:
200020484
5.
Full record GDS3787

CXC chemokine ligand 4 effect on monocyte-derived macrophages

Analysis of blood monocytes differentiated to macrophages (MP) with CXC Chemokine Ligand 4 (CXCL4) and macrophage colony-stimulation factor (M-CSF). In atherosclerotic arteries, monocytes differentiate to MPs in the presence of growth factors, such as M-CSF, and chemokines, such as CXCL4.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE20484
4 Samples
Download data: CEL
6.

Expression Data From HCMV-Infected Human Monocytes Study 2

(Submitter supplied) Human cytomegalovirus induces a pro-inflammatory monocyte following infection. To begin to address how HCMV induces these rapid changes in infected monocytes, we examined the transcriptome of infected monocytes. Global transcriptional profiling using cDNA microarrays revealed a significant number of pro-inflammatory genes were upregulated within 4 hours post infection. Keywords: Disease State
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE11408
ID:
200011408
7.

Mesenchymal stromal cells perturb human monocyte in vitro differentiation into dendritic cells

(Submitter supplied) Monocytes cultured in media containing GM-CSF and IL4 for 5 days normally differentiate into immature dendritic cells which, upon further stimulation with LPS for an additional 2 days, acquire a mature phenotype. In the present study, we evaluated the effect of human cord-blood mesenchymal stem cells (MSC) on human monocyte differentiation into immature and mature DCs by examining the trancriptional profile of the cells that were obtained after both the differentiation and maturation stages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
18 Samples
Download data: TXT
Series
Accession:
GSE68962
ID:
200068962
8.

Inflammatory Expression Profiles in Monocyte to Macrophage Differentiation amongst Patients with Systemic Lupus Erythematosus and Healthy Controls with and without an Atherosclerosis Phenotype

(Submitter supplied) To examine mononuclear cell gene expression profiles in patients with and without SLE and subsets with and without atherosclerosis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
72 Samples
Download data: TXT
Series
Accession:
GSE37356
ID:
200037356
9.

RNA-seq of human peripheral blood mononuclear cells

(Submitter supplied) Inflammatory cytokine responses to activation of innate immunity differ between individuals, yet the genomic and transcriptomic determinants of inflammatory responsiveness are not well understood. We hypothesized that mRNA and lincRNA expression is modulated in disease-relevant tissues in humans in vivo during inflammation, and differs between individuals with divergent evoked inflammatory responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
30 Samples
Download data: DIFF
Series
Accession:
GSE87290
ID:
200087290
10.

Human monocyte-derived macrophages polarized by GM-CSF or M-CSF

(Submitter supplied) Identification of genes differentially expressed between human monocyte-macrophages generated in the presence of either GM-CSF (termed M1) or M-CSF (termed M2)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11010
6 Samples
Download data: TXT
Series
Accession:
GSE27792
ID:
200027792
11.

Gene expression profile during monocytes to macrophage differentiation

(Submitter supplied) Macrophages play a critical role in the pathogenesis of many diseases, including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Monocytes recruited into tissues from peripheral blood differentiate into macrophages. There is limited data concerning the global changes in the expression of genes during monocyte to macrophage, and how the patterns of change identify the mechanism contributing to differentiation or macrophage function. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3203
Platform:
GPL96
9 Samples
Download data: CEL
Series
Accession:
GSE8286
ID:
200008286
12.
Full record GDS3203

Monocyte to macrophage differentiation

Analysis of monocytes following up to 168 hours of adherence-induced differentiation. Monocytes differentiate into macrophages, which are critical in the pathogenesis of many diseases. Results provide insight into the molecular mechanisms underlying monocyte to macrophage differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell type, 3 time sets
Platform:
GPL96
Series:
GSE8286
9 Samples
Download data: CEL
13.

Colony stimulating factor-1 receptor signaling networks inhibit macrophage inflammatory responses by induction of microRNA-21

(Submitter supplied) Macrophage polarization between the M2 (repair, pro-tumorigenic) and M1 (inflammatory) phenotypes is seen as a continuum of states. The detailed transcriptional events and signals downstream of CSF-1R that contribute to amplification of the M2 phenotype and suppression of the M1 phenotype are largely unknown. Macrophage CSF-1R pTyr-721 signaling promotes cell motility and enhancement of tumor cell invasion in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
32 Samples
Download data: CEL
Series
Accession:
GSE62630
ID:
200062630
14.

Extensive overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte-derived differentiating macrophages

(Submitter supplied) Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) g or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: TXT
Series
Accession:
GSE100889
ID:
200100889
15.

Homogeneous monocytes and macrophages from hES cells following coculture-free differentiation in M-CSF and IL-3.

(Submitter supplied) In the present study we aimed at producing homogeneous populations of monocytes and macrophages from human embryonic stem (hES) cells. Human embryonic stem cell lines KCL001, KCL002, and HUES-2 were differentiated into monocytes by coculture-free differentiation with two growth factors using a three-step method. The method involved embryoid body (EB) formation in hES media, directed differentiation with macrophage colony-stimulating factor and interleukin (IL)-3, and harvest of nonadherent monocytes from the culture supernatants. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE15791
ID:
200015791
16.

microRNA expression during tumor-associated macrophage (TAM) differentiation

(Submitter supplied) To further analyze the change of microRNA(miRNA) between normal peritoneal macrophage(PEC) and TAM from early tumor(12 days after 4T1 cell injection) or TAM from late tumor(21 days after 4T1 cell injection) , we employed Agilent mouse microRNA microarray Rel 12.0 as a discovery platform to identify miRNAs
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL9756
9 Samples
Download data: TXT
Series
Accession:
GSE67408
ID:
200067408
17.

Similarities and differences between human activated macrophages II

(Submitter supplied) We compare, in human macrophages, stimuli considered to induce M1 or M2 type of activation, also termed classical and alternative activation. This dataset highlights key differences between the M1 and M2 stimuli pointing to the need of a revision of the paradigm. Macrophages were left untreated or stimulated with IL-4 and IL-13 (prototypic M1 stimuli), Dexamethasone (Glucocorticoid receptor agonist) which has been hitherto considered M2, IL-10 which also falls under the M2 umbrella, and LPS and Interferon Gamma considered M1 stimuli. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
7 Samples
Download data: TXT
Series
Accession:
GSE51446
ID:
200051446
18.

Similarities and differences between human activated macrophages I

(Submitter supplied) The human AA dataset 5 includes the gene expression profile of monocyte-derived macrophages isolated from blood donor buffy coats and plated on TCP in medium containing 10% autologous serum. Cells were stimulated for 120 hours with 50 ng/ml of IL-4, 50 U/ml of IFN-γ plus 12.5 ng/ml of TNF-α, 50 ng/ml of M-CSF or 50 ng/ml of IL-10. RNA samples were isolated using TriPure isolation reagent (Roche) and the RNeasy Mini Kit-Qiagen Clean up method. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE49240
ID:
200049240
19.

Genome-wide analysis of human and mouse macrophages, resting and activated

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
5 related Platforms
73 Samples
Download data: CEL
Series
Accession:
GSE35495
ID:
200035495
20.

Genome-wide analysis of mouse macrophages stimulated with IL-4 (Biogel and thioglycollate macrophages) (Affymetrix)

(Submitter supplied) Analysis of alternative activation of macrophages at gene expression level. The study forms part of a wider study where we compare the effects of IL-4 in different human and mouse macrophages. Our results support the notion that in vitro culture conditions greatly affect the macrophage response to IL-4. Total RNA obtained from Thioglycollate and Biogel elicited peritoneal macrophages exposed to 20 ng/ml of IL-4 for 18 hours.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE35436
ID:
200035436
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