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Links from GEO DataSets

Items: 20

1.

Expression data from B. melitensis infected mouse macrophages

(Submitter supplied) Facultative intracellular Brucella infect and survive inside macrophages, and the outcome of macrophage-Brucella interaction is a basis for establishment of a chronic Brucella infection. The majority of Brucella are killed at the early infection stage. A subpopulation of virulent Brucella strains is instead trafficked to an intracellular replicative phagosome, and are resistant to further attack and begin to multiply dramatically. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5202
ID:
200005202
2.

RAW264.7 macrophages infected with Brucella abortus, B. melitensis, B. neotomae, and B. ovis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by SAGE
Platforms:
GPL81 GPL32
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE8403
ID:
200008403
3.

Host RAW264.7 macrophage transcript profile following Brucella melitensis, B. neotomae, and B. ovis infections

(Submitter supplied) Brucella dynamically engage macrophages while trafficking to an intracellular replicative niche as macrophages, the first line of innate host defense, attempt to eliminate organisms. Brucella melitensis, B. neotomae, and B. ovis are highly homologous, yet exhibit a range of host pathogenicity and specificity. RAW 264.7 macrophages infected with B. melitensis, and B. ovis exhibit divergent patterns of bacterial persistence and clearance; conversely, B. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE8385
ID:
200008385
4.

Microarrays of macrophages infected with smooth or rough Brucella suis

(Submitter supplied) The macrophage-Brucella interaction is critical for the establishment of a chronic Brucella infection. Smooth virulent B. suis strain 1330 (S1330) prevents macrophage cell death. However, rough attenuated B. suis strain VTRS1 induces strong macrophage cell death. To further investigate the mechanism of VTRS1-induced macrophage cell death, microarrays were used to analyze temporal transcriptional responses of murine macrophage-like J774. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4432
Platform:
GPL1261
42 Samples
Download data: CEL
Series
Accession:
GSE21117
ID:
200021117
5.
Full record GDS4432

Rough attenuated Brucella suis strain infection effect on macrophage cell line: time course

Analysis of J774.A1 macrophage cells for up to 48 hours following infection with S1330-smooth virulent or VTRS1-rough attenuated Brucella suis strain. S1330 prevents macrophage cell death while VTRS1 induces it. Results provide insight into the molecular basis of VTRS1-induced macrophage cell death.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 infection, 7 time sets
Platform:
GPL1261
Series:
GSE21117
42 Samples
Download data: CEL
6.

Deep sequencing analysis of the murine transcriptome response to different virulent parenthood B. melitensis infection

(Submitter supplied) In this study, we employed the Illumina Genome Analyzer platform to perform a Digital Gene Expression (DGE) analysis of the peritoneal macrophages genome-wide transcriptome response to B.melitensis infection. Common changes in gene expression were observed among Brucella app. infected macrophages suggesting similar strategies were employed for their survival and replication, inducing anti-inflammatory and anti-apoptotic. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9250
3 Samples
Download data
Series
Accession:
GSE26337
ID:
200026337
7.

Comparative transcriptome analysis of Brucella melitensis 16M and its hfq mutant under acidified minimum medium (GEM4.0) conditions

(Submitter supplied) Hfq is a bacterial Sm-like protein which serves as a post-transcriptional regulator of global gene expression. It has been shown to be involved in a wide range of cellular processes and pathways. To characterize the regulation roles of Hfq in Brucella melitensis, the in vitro hfq induction conditions simulating intracellular environments were firstly defined, and then, the transcriptome of the hfq mutant was compared to that of the wild type strain. more...
Organism:
Brucella melitensis; Brucella melitensis bv. 1 str. 16M
Type:
Expression profiling by array
Platform:
GPL11117
4 Samples
Download data: GPR
Series
Accession:
GSE46418
ID:
200046418
8.

Expression response of Brucella melitensis strain 16M (ATCC23456) to erythritol

(Submitter supplied) The four-carbon sugar erythritol is an important component of B. melitensis pathogenesis. To determine the transcriptional response to erythritol, B. melitensis strain 16M was grown in the presence of either glucose or erythritol as a sole carbon source.
Organism:
Brucella melitensis bv. 1 str. 16M
Type:
Expression profiling by array
Platform:
GPL15533
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE37819
ID:
200037819
9.

Brucella melitensis global gene expression

(Submitter supplied) In this study we report that B. melitensis at the late logarithmic phase of growth are more invasive for HeLa cells than at mid logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase compared to the stationary growth phase. The vast majority of the up-regulated genes in late-log cultures were those associated with DNA replication, transcription and translation, intermediate metabolism, energy production and conversion, membrane transport and cell envelope, biogenesis and outer membrane, while the down-regulated genes were distributed among several functional categories. more...
Organism:
Brucella melitensis
Type:
Expression profiling by array
Platform:
GPL6748
8 Samples
Download data: GPR
Series
Accession:
GSE11192
ID:
200011192
10.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Brucella ovis; Brucella melitensis; Brucella melitensis bv. 1 str. 16M; Brucella canis
Type:
Expression profiling by array
Platforms:
GPL15024 GPL15023
16 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34504
ID:
200034504
11.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 4)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella ovis; Brucella canis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34503
ID:
200034503
12.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 3)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella canis; Brucella ovis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34501
ID:
200034501
13.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 2)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella canis; Brucella ovis
Type:
Expression profiling by array
Platform:
GPL15024
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34498
ID:
200034498
14.

Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 1)

(Submitter supplied) Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteria, gene transcription was examined during infection of murine macrophages and compared to bacteria grown in broth. more...
Organism:
Brucella melitensis bv. 1 str. 16M; Brucella melitensis
Type:
Expression profiling by array
Platform:
GPL15023
4 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE34495
ID:
200034495
15.

Microarray of Genes affected by BlxR deletion

(Submitter supplied) A mini-microarray containing spotted oligos corresponding to 289 B. melitensis genes was used to identify candidate genes whose transcription is influenced by BlxR. This microarray contains genes encoding the type IV secretion system, flagella, transcriptional regulators, transporters, and proteins involved in outer membrane biogenesis, iron acquisition, and denitrification. RNA was prepared from both B. more...
Organism:
Brucella melitensis
Type:
Expression profiling by array
Platform:
GPL6170
14 Samples
Download data
Series
Accession:
GSE10735
ID:
200010735
16.

Response of murine splenocytes to infection with wild type or virB mutant Brucella strains

(Submitter supplied) The virB operon, encoding a Type IV secretion system (T4SS), is essential for intracellular survival and persistent infection of Brucella spp. To better understand the role of the T4SS in evading host defense mechanisms and establishing chronic infection, we compared transcriptional profiles of the host response to infection with wild type Brucella strains and strains that fail to express the virB genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2859
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE6810
ID:
200006810
17.
Full record GDS2859

Splenocyte response to infection by virB mutant Brucella strains

Analysis of splenocytes from animals infected with virB mutant Brucella arbortus strains. The virB operon encodes a Type IV secretion system (T4SS) essential for the intracellular survival and persistent infection by Brucella species. Results provide insight into the role of T4SS in infections.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 genotype/variation, 3 infection sets
Platform:
GPL1261
Series:
GSE6810
10 Samples
Download data: CEL
DataSet
Accession:
GDS2859
ID:
2859
18.

Intracellular Brucella melitensis gene expression

(Submitter supplied) Brucella spp. is an intracellular pathogen in vivo. The intracellular B. melitensis transcriptome was determined by initially enriched and then amplified B. melitensis RNA from total RNA of B. melitensis-infected HeLa cells. Analysis of microarray results identified 161 and 115 genes differentially expressed at 4 and 12 h p.i., respectively. Most of the genes (78%) differentially expressed were down-regulated at the earliest time point, but up-regulated (75%) at 12 h p.i. more...
Organism:
Brucella melitensis bv. 1 str. 16M; Brucella melitensis
Type:
Expression profiling by array
Platform:
GPL8156
18 Samples
Download data: GPR
Series
Accession:
GSE14704
ID:
200014704
19.

Brucella melitensis-infected HeLa cells gene expression

(Submitter supplied) In a time course study, we characterized global gene expression profile of B. melitensis-infected epithelium-like cells at the onset of infection. B. melitensis-infected HeLa cells exhibited a down-regulated expression profile at 4 h (48 up- and 109 down-regulated genes) that transitioned to an activated transcriptional profile at 12 h post-infection (733 up- and 224 down-regulated genes). The analysis of the results indicates that infected cells undergo an adaptation period during the first 4 h p.i. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8155
16 Samples
Download data: GPR
Series
Accession:
GSE14703
ID:
200014703
20.

PrlR regulon in Brucella melitensis 16M

(Submitter supplied) Investigation of whole genome gene expression level changes in a Brucella melitensis delta prlr mutant compared to the wild type strain. The mutants analyzed in this study are further described in A. Mirabella, R-M Yanez, R.M. Delrue, S. Uzureau, M.S. Zygmunt, A. Cloeckaert, X. De Bolle, J.J. Letesson (2012). The two component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength. more...
Organism:
Brucella melitensis bv. 1 str. 16M
Type:
Expression profiling by array
Platform:
GPL5730
6 Samples
Download data: PAIR
Series
Accession:
GSE34633
ID:
200034633
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