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Links from GEO DataSets

Items: 20

1.

mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex

(Submitter supplied) Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxidative activity is unknown. Here, we show that mTOR kinase activity stimulates mitochondrial gene expression and oxidative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5332
ID:
200005332
2.

Expression data from mouse skeletal muscle

(Submitter supplied) We generated skeletal muscle-specific knockout mice lacking the transcription factor Yin Yang 1 (YY1) and analyzed expression patterns in the skeletal muscle these mice. We used microarrays to detail the global programme of gene expression regulated by YY1.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4856
Platform:
GPL8321
7 Samples
Download data: CEL
Series
Accession:
GSE39009
ID:
200039009
3.
Full record GDS4856

Transcription factor Yin Yang 1 deficiency effect on the skeletal muscle

Analysis of the soleus muscles of transcription factor Yin Yang 1 (YY1) deficient animals. Many nuclear genes encoding mitochondrial proteins contain binding sites for YY1 in their proximal promoters. Results provide insight into the role of YY1 in mitochondrial function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE39009
7 Samples
Download data: CEL
4.

Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.

(Submitter supplied) Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation and reactive oxygen species scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1a is a transcriptional coactivator that regulates mitochondrial function and is induced by CR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE34773
ID:
200034773
5.

lipin 1beta overexpression in mouse liver

(Submitter supplied) Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. Lipin 1 appears to be highly involved in the control of fatty acid metabolism. Lipin 1 is most often located in the nucleus, but other studies suggest that lipin also has effects in the cytoplasm. However, the molecular function of lipin 1 is unclear. To evaluate the effects of activation of the lipin 1 system in liver, lipin 1beta was overexpressed in mouse liver using an adenoviral vector. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2291
Platform:
GPL339
4 Samples
Download data
Series
Accession:
GSE5538
ID:
200005538
6.
Full record GDS2291

Lipin 1-beta overexpression effect on the liver

Analysis of livers of transgenics overexpressing lipin 1-beta, an alternative form of lipin 1 containing a 33 amino acid insertion. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld animals, a genetic model of lipodystrophy. Results provide insight into the function of lipin 1.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE5538
4 Samples
Download data
DataSet
Accession:
GDS2291
ID:
2291
7.

Gene Expression Profiling of PGC-1a KO mouse striata

(Submitter supplied) Huntington’s Disease (HD) is an inherited neurodegenerative disease caused by a glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered energy metabolism have been implicated in HD pathogenesis. We report here that mutant huntingtin causes disruption of mitochondrial function by inhibiting expression of PGC-1a, a transcriptional coactivator that regulates several metabolic processes including mitochondrial biogenesis and respiration. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2391
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5786
ID:
200005786
8.
Full record GDS2391

PGC-1alpha transcriptional coactivator null mutation effect on the brain striatum

Analysis of brain striatum of PGC-1alpha transcriptional coactivator null mutants. PGC-1alpha regulates several metabolic processes. Altered energy metabolism is implicated in Huntington's disease (HD). Results provide insight into the role of PGC-1alpha in HD pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5786
6 Samples
Download data
DataSet
Accession:
GDS2391
ID:
2391
9.

Gene expression analysis of Ncor1 muscle-specific knockout and PGC-1alpha muscle-specific transgenic skeletal muscle

(Submitter supplied) In the present study we have studied the mechanistic and functional aspects of NCoR1 function in mouse skeletal muscle. NCoR1 muscle-specific knockout mice exhibited an increased oxidative metabolism. Global gene expression analysis revealed a high overlap between the effects of NCoR1 deletion and peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1alpha (PGC-1alpha) overexpression on oxidative metabolism in skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
20 Samples
Download data: CEL
Series
Accession:
GSE40439
ID:
200040439
10.

Pyruvate induces mitochondrial biogenesis by a PGC-1alpha independent mechanism

(Submitter supplied) The present study examines the impact of altering energy provision on mitochondrial biogenesis in muscle cells. C2C12 myoblasts were chronically treated with supraphysiological levels of sodium pyruvate for 72 hr. Treated cells exhibited increased mitochondrial protein expression, basal respiratory rate and maximal oxidative capacity. The increase in mitochondrial biogenesis was independent of increases in PGC-1alpha and PGC-1alpha mRNA expression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2265
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5497
ID:
200005497
11.
Full record GDS2265

Pyruvate effect on muscle cells

Analysis of C2C12 myoblasts treated with supraphysiological levels of sodium pyruvate for 72 hours. Pyruvate increases mitochondrial biogenesis in muscle myoblasts. Results provide insight into the impact of altering energy provision on mitochondrial biogenesis in muscle cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1261
Series:
GSE5497
6 Samples
Download data
DataSet
Accession:
GDS2265
ID:
2265
12.

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4897
Platform:
GPL571
16 Samples
Download data: CEL
Series
Accession:
GSE36297
ID:
200036297
13.
Full record GDS4897

Skeletal muscle of patients with inherited insulin resistance

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL571
Series:
GSE36297
16 Samples
Download data: CEL
DataSet
Accession:
GDS4897
ID:
4897
14.

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(Submitter supplied) The study aimed to analyse the transcriptome of mouse cancer cells while in primary tumor, in circulation and after homing to metastatic site. The model used here is the 4T1 cancer cell orthotopic model.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE37344
ID:
200037344
15.

Gene expression from Prep1-ablated mice

(Submitter supplied) The homeodomain transcription factor Prep1 was previously shown to regulate insulin sensitivity. Our aim was to study the specific role of Prep1 for the regulation of energy metabolism in skeletal muscle. Muscle specific ablation of Prep1 resulted in increased expression of respiratory chain subunits. This finding was consistent with an increase in mitochondrial enzyme activity without affecting mitochondrial volume fraction as assessed by electron microscopy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
8 Samples
Download data: TXT
Series
Accession:
GSE52424
ID:
200052424
16.

Analysis of TLS activity in PGC-1alpha+/+ and PGC-1alpha-/- hepatocytes

(Submitter supplied) We found that TLS can work as a PGC-1alpha cofactor and this assay was carried out to test the functional dependency of TLS on PGC-1alpha on a whole genome scale
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE23242
ID:
200023242
17.

Genome-wide coactivation screen identifies BAF60a as a regulator of lipid metabolism through PGC-1alpha

(Submitter supplied) Impaired mitochondrial function has been implicated in the pathogenesis of type 2 diabetes, heart failure and neurodegeneration as well as during aging. Studies with the PGC-1 transcriptional coactivators have demonstrated that these factors are key components of the regulatory network that controls mitochondrial function in mammalian cells. Here we describe a genome-wide coactivation assay to globally identify the transcriptional partners for PGC-1α. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE9523
ID:
200009523
18.

ChIP-chip analyses of PR- related pathway in human oncocytic thyroid tumor cell line XTC.UC1

(Submitter supplied) ChIP-chip analyses of five transcription factors (ERR1, GABP, NRF1, CREB and YY1) PRC coactivator and RNA polymerase II in XTC.UC1 cells compared to non specific IP (IgG or input) seven factors studied: ERR1, GABP, NRF1, CREB, YY1, PRC, RNAPolII
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL8167
14 Samples
Download data: TXT
Series
Accession:
GSE106597
ID:
200106597
19.

miRNA expression profiles of PRC SiRNA vs scramble transfected XTC.UC1 cells

(Submitter supplied) PGC-1 related coactivator (PRC) shares structural and functional features with PGC-1{alpha}. It regulates several metabolic pathways and mitochondrial biogenesis. Its specific role in the early programming of cell proliferation suggests a finely regulated crosstalk between the mitochondrial functions and the cell cycle status. To explore the PRC-regulated pathways, we used a cell-line model of mitochondrial-rich tumors, presenting an oxidative metabolism and a specific increase in PRC expression. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8936
4 Samples
Download data: TXT
Series
Accession:
GSE33843
ID:
200033843
20.

PRC SiRNA vs scramble transfection in XTC.UC1 cells

(Submitter supplied) PGC-1 related coactivator (PRC) shares structural and functional features with PGC-1{alpha}. It regulates several metabolic pathways and mitochondrial biogenesis. Its specific role in the early programming of cell proliferation suggests a finely regulated crosstalk between the mitochondrial functions and the cell cycle status. To explore the PRC-regulated pathways, we used a cell-line model of mitochondrial-rich tumors, presenting an oxidative metabolism and a specific increase in PRC expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7674
41 Samples
Download data: GPR
Series
Accession:
GSE14282
ID:
200014282
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