GEO DataSets

(Submitter supplied) H295R human adrenocortical cells were cultured in H295R complete media containing DMEM:F12 (1:1) supplemented with 2% Ultroser G (Biosepra, Villeneuve-la-Garenne, France), ITS-Plus (Discovery Labware, Bedford, MA) and an antibiotic/antimycotic mixture (Invitrogen, Carlsbad, CA) in 175 cm2 flasks until subconfluente. Media was replaced with 40 ml fresh media containing different agents and cultured for 3 h. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL97 GPL96

10 Samples

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(Submitter supplied) Angiotensin II (Ang-II) regulates adrenal steroid production and gene transcription through several signaling pathways. Changes in gene transcription occur within minutes after Ang-II stimulation, causing an acute increase in aldosterone production and subsequent increase in the overall capacity to produce aldosterone. Our goal was to compare the Ang-II regulation of early gene expression and confirm the upregulation of selected genes using quantitative real-time RT-PCR (qPCR) across three species: human, bovine, and rat. more...

Organism:

Homo sapiens; Bos taurus; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL2112 GPL570 GPL1355

12 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), the phase 3 morbidity and mortality trial of torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor, identified previously undescribed changes in plasma levels of potassium, sodium, bicarbonate, and aldosterone. A key question after this trial is whether the failure of torcetrapib was a result of CETP inhibition or of some other pharmacology of the molecule. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3556

Platform:

GPL570

9 Samples

Download data: CEL

Analysis of H295 adrenal carcinoma cells treated with torcetrapib, an anti-cholesterol drug. Adverse side effects of torcetrapib treatment include changes in blood pressure, potassium, sodium, and aldosterone. Results provide insight into the molecular basis of the off-target side effects.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent sets

Platform:

GPL570

Series:

GSE15918

9 Samples

Download data: CEL

(Submitter supplied) H295R human adrenocortical cells treated with or without angiotensin II (100 nM) for 3 hr. Keywords = adrenal angiotensin aldosterone Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL350 GPL351

16 Samples

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