GEO DataSets

(Submitter supplied) These samples comprise the full analysis of liver function during response to thermal injury. Keywords: Time Course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

12 Samples

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(Submitter supplied) Type of experiment: Comparison of liver samples between sham (control) and 20% TBSA (total burn surface area) burn rats collected at 1h, 4h, 8h, and 24h. Experimental factors: Burn injury and time Experiment design: All experimental liver samples collected after 1h, 4h, 8h, and 24h after burn injury were compared to a common reference (sham control treated as 0h time point) Bio source: Sprague-Drawley male rats weighing 150-200 g supplied through Charles river laboratories, MA (www.criver.com) Bio material manipulations: Rats (n=3 for each scald-burn and sham-burn time point) were individually housed in a temperature-controlled (25oC) and light-controlled room (12h light-dark cycle) and allowed to adjust to their new surroundings for at least 5 days prior to the experiment. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS599

Platform:

GPL85

10 Samples

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Temporal analysis of metabolic and inflammatory response to burn injury. Livers from male Sprague-Dawleys examined at 1, 4, 8, and 24 hours following 20% total burn surface area scald-burn injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 time sets

Platform:

GPL85

Series:

GSE802

10 Samples

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(Submitter supplied) The experimental design included three biological replicates for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2235

Platform:

GPL341

9 Samples

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Analysis of livers of animals subjected to moderate burn injury followed two days later by cecum ligation and puncture (CLP) to produce sepsis. The dual insult induces a systemic hypermetabolic state. Results provide insight into regulation of the hypermetabolic response in the liver.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL341

Series:

GSE1781

9 Samples

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(Submitter supplied) We report here the genes that are sequentially expressed in white blood cells from blood and spleen at 2 hours, 2 day,3 days, and 7 days after burn and sham injury or trauma-hemorrhage (T-H) and sham T-H. Includes WBC treated with LPS for 2 hours and 1 day.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

144 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL