GEO DataSets

(Submitter supplied) Several studies have shown that bone mineral density (BMD), a clinically measurable predictor of osteoporotic fracture, is the sum of genetic and environmental influences. In addition, serum IGF-1 levels have been correlated to both BMD and fracture risk. We previously identified a Quantitative Trait Locus (QTL) for Bone Mineral Density (BMD) on mouse Chromosome (Chr) 6 that overlaps a QTL for serum IGF-1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2442

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of livers of animals with decreased serum insulin-like growth factor-I (IGF-I) levels. The liver is the major source of serum IGF-I. The level of serum IGF-I is correlated to bone mineral density (BMD) and fracture risk. Results provide insight into the relationship between IGF-I and BMD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE5959

6 Samples

Download data: CEL

(Submitter supplied) right lung gene expression of C57BL/6J, A/J and C3H/HeJ mice following bleomcyin exposure Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1492

Platform:

GPL339

21 Samples

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Comparison of lungs from C57BL/6J and C3H/HeJ strains, 3 and 6 weeks after treatment with 80, 100, or 125 units of bleomycin/kg. C57BL/6Js are susceptible to bleomycin-induced pulmonary fibrosis, while C3H/HeJs are resistant. Results identify candidate genes underlying fibrosis susceptibility.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 dose, 2 gender, 2 other, 3 strain, 3 time sets

Platform:

GPL339

Series:

GSE2640

21 Samples

Download data

(Submitter supplied) We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity related phenotypes. The B6.S-2 congenic donor region spanned a minimum of 26 Mb. In this study, we constructed five overlapping subcongenics with smaller SPRET/Ei donor regions to fine map the underlying gene(s). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4479

24 Samples

Download data: TXT

(Submitter supplied) A congenic line was constructed by introgressing a C3H chromosome 1 region harboring Bglu3 into C57BL/6 apoE-/- background. RNA was extracted from liver using a QIAGEN kit . Total RNA was pooled in an equal amount from 3 mice for each group. Standard Affymetrix procedures were performed using 8ug of total RNA. Microarrays were used to detect gene expression in the liver of Bglu3 congenic mice and C57BL/6 apoE-deficient mouse strains fed a western diet.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

2 Samples

Download data: CEL

(Submitter supplied) SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. The liver weight and liver triglyceride content of A/J-12SM consomic mouse was lower than that of A/J mouse. In contrast, the epididymal fat weight tended to be higher in A/J-12SM consomic mouse than that in A/J. We compared the epididymal fat's gene expressions between A/J mouse and A/J-12SM consomic mouse.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

2 Samples

Download data: CEL, CHP

(Submitter supplied) SMXA-5 mouse shows a high-fat induced fatty liver. The QTL for fatty liver was mapped on mouse chromosome 12, designated as Fl1sa. The liver triglycerides content of A/J-12SM consomic mouse, a chromosome substitution strain, was suppressed compared to that of A/J mouse. We compared the hepatic gene expressions between A/J mouse and A/J-12SM consomic mouse.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

311 Samples

Download data

(Submitter supplied) Oligonucleotide array on glass. Contains 60mer probes designed against 23,000+ mouse genes arrayed on Agilent ink-jet arrays. Keywords=mouse genetics gene expression oligonucleotide Protocol: Agilent:HW:2520

Organism:

Mus musculus

14 Series

2429 Samples

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(Submitter supplied) The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

292 Samples

Download data

(Submitter supplied) The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

285 Samples

Download data

(Submitter supplied) The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

302 Samples

Download data

(Submitter supplied) The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

295 Samples

Download data: TXT

(Submitter supplied) The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

319 Samples

Download data

(Submitter supplied) The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

249 Samples

Download data

(Submitter supplied) The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

295 Samples

Download data

(Submitter supplied) Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5270

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE46443

12 Samples

Download data: CEL

(Submitter supplied) Our data demonstrates enrichment of the GO term extracellular region among the decreased lung transcripts of JF1 throughout the process of lung development and maturation in consistent to the altered elastin to collagen ratio. Our microarray data showed increased ~4 fold increased elastin transcripts in JF1 lungs at P70. Specific CL‐saline/air ratio in JF1 mice compared to C3H (JF1-male: 2.68±01.10 versus C3H-male: 2.15±0.42, p<0.05; JF1-female: 3.22±0.88 versus C3H-female: 2.27±0.23, p<0.05) suggests that surface tension contributes more than the elastic recoiling properties of lung in determining the lung compliance as assessed by air filling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

30 Samples

Download data: CEL