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Links from GEO DataSets

Items: 9

1.

IFN-gamma activation of cultured neonatal rat microglia

(Submitter supplied) IFN-gamma is a classical microglial stimulant. We used microarrays to investigate the microglial gene regulatory network activated by interferon-gamma. Keywords: Microglia activation
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
10 Samples
Download data: CEL
Series
Accession:
GSE6353
ID:
200006353
2.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
3.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
4.

Effect of INF-gamma and IL1-beta on thyroid cells

(Submitter supplied) Normal primary thyroid cells were incubated with vehicle, 100 IU/ml IFN-gamma, 50 IU/ml IL1-beta, or a combination of both IFN-gamma and IL1-beta for 24 or 72 hours. The experiment was repeated 5 times using thyroid cells from 5 different patients. RNA expression was analyzed using Affymetrix HG_U133A arrays for 3 of the thyroids, and HG_U133A_2.0 (small version of HG_U133A) arrays for 2 of the thyroids. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2938 GDS2939
Platforms:
GPL96 GPL571
20 Samples
Download data: CEL, TXT, XLS
Series
Accession:
GSE5054
ID:
200005054
5.
Full record GDS2939

IFN-gamma and IL-1beta effect on thyroid epithelial cells (HG-U133A 2.0)

Analysis of thyroid epithelial cells (TECs) treated with IFN-gamma, IL-1beta, or both. Fas-mediated apoptosis plays a role in the pathogenesis of autoimmune thyroid diseases. TECs are resistant to Fas-mediated apoptosis, but the resistance is overcome by pretreatment with IFN-gamma and IL-1beta.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 agent, 2 individual sets
Platform:
GPL571
Series:
GSE5054
8 Samples
Download data: CEL
DataSet
Accession:
GDS2939
ID:
2939
6.
Full record GDS2938

IFN-gamma and IL-1beta effect on thyroid epithelial cells (HG-U133A)

Analysis of thyroid epithelial cells (TECs) treated with IFN-gamma, IL-1beta, or both. Fas-mediated apoptosis plays a role in the pathogenesis of autoimmune thyroid diseases. TECs are resistant to Fas-mediated apoptosis, but the resistance is overcome by pretreatment with IFN-gamma and IL-1beta.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 agent, 3 individual sets
Platform:
GPL96
Series:
GSE5054
12 Samples
Download data: CEL
DataSet
Accession:
GDS2938
ID:
2938
7.

Transcriptional Response of Human Microglial Cells to Interferon-gamma

(Submitter supplied) Microglial cells are resident macrophages in the central nervous system (CNS) and play a pivotal role in the innate and adaptive immune responses against microbial infections. The immune functions of microglia are regulated by a milieu of cytokines including interferon (IFN)-gamma. We here performed a series of experiments to acertain the transcriptional profile of human fetal microglial cells at 1, 6, and 24 h after IFN-gamma treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1036
Platform:
GPL96
24 Samples
Download data
Series
Accession:
GSE1432
ID:
200001432
8.
Full record GDS1036

Microglial cell response to interferon-gamma: time course

Expression profiling of microglial cells obtained from 4 different samples following treatment with 200 u/ml interferon-gamma (IFN-gamma). Cells examined 1, 6, and 4 hours after treatment. Results provide insight into the regulation of immune functions in microglia by IFN-gamma.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 specimen, 3 time sets
Platform:
GPL96
Series:
GSE1432
24 Samples
Download data
DataSet
Accession:
GDS1036
ID:
1036
9.

Cell line stimulated with recombinant cytokines interleukin-1b and interferon gamma.

(Submitter supplied) Interleukin 1b and interferon g are two cytokines that are central to the inflammatory response. They both have a broad range of activity, each directing the immune response to be towards either the innate response (IL-1b and IFN-g) or the cellular response (IFN-g), however invivo there is a lot of subtle interactions. Microarray analysis has been used to characterize the transcriptional response to recombinant rainbow trout IL-1b and IFN-g in a rainbow trout macrophage cell line RTS-11. more...
Organism:
Oncorhynchus mykiss; Salmo salar
Type:
Expression profiling by array
Platform:
GPL2899
12 Samples
Download data
Series
Accession:
GSE5091
ID:
200005091
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