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Links from GEO DataSets

Items: 11

1.

C2C12 Myotubes in response to Palmitate

(Submitter supplied) To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Keywords: Nutrient Effect
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2648
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE6766
ID:
200006766
2.
Full record GDS2648

Palmitate effect on myoblast cell line

Analysis of myoblasts treated with the saturated fatty acid palmitate. Muscle expression of PPAR coactivator 1 (PGC-1) is reduced in models of obesity. Palmitate decreases the expression of PGC-1. Results provide insight into the molecular basis of the link between overnutrition, obesity, and PGC-1.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE6766
6 Samples
Download data: CEL
DataSet
Accession:
GDS2648
ID:
2648
3.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
4.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
5.

High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

(Submitter supplied) Genes repressed by DNA methylation can be derepressed by various compounds targeting DNA methyltransferases, histone deacetylases, etc. Here, we report a high throughput screen against a 308,251-member chemical library aiming to identify novel small molecules that derepress an EGFP reporter gene silenced by DNA methylation. RNA-seq was used to measure mRNA abundance in control and compound-treated cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL23227 GPL20301
24 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE106573
ID:
200106573
6.

Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL18573 GPL11154
43 Samples
Download data
Series
Accession:
GSE126102
ID:
200126102
7.

Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [RNA-seq]

(Submitter supplied) Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors, and characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority is located in non-coding DNA regions. This suggest that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: CSV
Series
Accession:
GSE126101
ID:
200126101
8.

Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [cHiC-seq]

(Submitter supplied) Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors, and characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority is located in non-coding DNA regions. This suggest that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
6 Samples
Download data: CSV
9.

Skeletal muscle enhancer interactions identify genes controlling whole body metabolism in humans [ChIP-seq]

(Submitter supplied) Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors, and characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority is located in non-coding DNA regions. This suggest that most variants mediate their effect by altering the activity of gene-regulatory elements, including enhancers. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
25 Samples
Download data: BED, BW, CSV
Series
Accession:
GSE126099
ID:
200126099
10.

Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids

(Submitter supplied) Diabetes mellitus, obesity, and dyslipidemia increase risk for cardiovascular disease, and expose the heart to high plasma fatty acid (FA) levels. Recent studies suggest that distinct FA species are cardiotoxic (e.g., palmitate), while others are cardioprotective (e.g., oleate), although the molecular mechanisms mediating these observations are unclear. The purpose of the present study was to investigate the differential effects of distinct FA species (varying carbon length and degree of saturation) on adult rat cardiomyocyte (ARC) gene expression. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3648
Platform:
GPL10239
46 Samples
Download data: TXT
Series
Accession:
GSE21023
ID:
200021023
11.
Full record GDS3648

Cardiomyocyte response to various types of fatty acids in vitro

Analysis of cardiomyocytes treated with 0.4 mM octanoate, palmitate, stearate, oleate, or linoleate for 24 hours. Studies suggest that distinct fatty acid species are cardiotoxic, while others are cardioprotective. Results provide insight into the molecular basis of these effects on the heart.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 6 agent sets
Platform:
GPL10239
Series:
GSE21023
46 Samples
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