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Links from GEO DataSets

Items: 20

1.

Gene expression profile of peripheral blood lymphocytes: comparison between melanoma patients and healthy controls

(Submitter supplied) We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC samples. Gene expression profiles of these cell populations from melanoma patients were compared to healthy controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2735
Platform:
GPL887
46 Samples
Download data
Series
Accession:
GSE6887
ID:
200006887
2.
Full record GDS2735

Metastatic melanoma: peripheral blood lymphocytes

Analysis of sorted peripheral blood lymphocytes (CD8 T cells, CD4 T cells, B cells, NK cells) from patients with melanoma. These subpopulations are involved in antitumor responses and negatively impacted by cancer. Results provide insight into molecular mechanisms of immune dysfunction in cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 4 cell type, 2 disease state sets
Platform:
GPL887
Series:
GSE6887
46 Samples
Download data
3.

The effect of IFNα on human CD8 T cells_with other concomitant signals

(Submitter supplied) IFN alpha mediated gene expression pattern. The effect of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs. This analysis examined the effects of IFN alpha on human CD8 T cells responding to antigen (signal 1) and costimulatory signals (signal 2) provided by beads coated with anti-CD3 and anti-CD28 mAbs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
15 Samples
Download data: CEL
Series
Accession:
GSE17301
ID:
200017301
4.

Periodontitis is associated with a type-1 interferon signature in peripheral blood neutrophils

(Submitter supplied) Peripheral blood neutrophils from periodontitis patients exhibit a hyper-reactive and hyper-active phenotype (collectively termed hyper-responsivity) in terms of production of reactive oxygen species (ROS) however the molecular basis for this observation is yet to be determined. Our objectives were to identify genes differentially expressed in hyper-responsive peripheral blood neutrophils from chronic periodontitis patients relative to periodontally healthy controls and use this data to identify potential contributory pathways to the hyper-responsive neutrophil phenotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE12484
ID:
200012484
5.

Progressive immune activation and negative immunoregulation from common melanocytic nevi to dysplastic nevi to melanoma

(Submitter supplied) The purpose of this study was to comprehensively study and compare the molecular gene expression profiles of common melanocytic nevi (GSE53223), dysplastic nevi (GSE53223), and primary melanoma.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
34 Samples
Download data: CEL
Series
Accession:
GSE114445
ID:
200114445
6.

Comparative gene expression profiles of immune inhibitory and non-inhibitory melanoma cell lines

(Submitter supplied) Dysfunction in type I interferon (IFN) signaling occurs in patients with stage II or more advanced cancer. After screening the effects of a panel of 12 melanoma cell lines on PBMCs of healthy volunteers of IFNalpha signal pathway, two groups of melanoma cell lines could be identified one with stronger suppression (low pSTAT-1 group) than the other (high pSTAT-1 group). Comparative global gene expression between two groups identified 6771 differential expression genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
65 Samples
Download data: CEL
Series
Accession:
GSE44851
ID:
200044851
7.

CGH array profiles of melanoma cell lines

(Submitter supplied) Dysfunction in type I interferon (IFN) signaling occurs in patients with stage II or more advanced cancer. After screening the effects of a panel of 12 melanoma cell lines on PBMCs of healthy volunteers of IFNalpha signal pathway, two groups of melanoma cell lines could be identified one with stronger suppression (low pSTAT-1 group) than the other (high pSTAT-1 group). Comparative genomic hybridization (CGH) identified consistent amplification of 12q22-24 as a genomic marker for the immune suppressive melanoma cell lines. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL4093
12 Samples
Download data: TXT
Series
Accession:
GSE44850
ID:
200044850
8.

Comparison of matched primary and metastasis 4T1.2 syngeneic mammary tumor model of spontaneous bone metastasis

(Submitter supplied) Breast cancer metastasis to bone is a critical determinant of long-term survival after treatment of primary tumors. We used a mouse model of spontaneous bone metastasis to determine new molecular mechanisms. Differential transcriptome comparisons of primary and metastatic tumor cells revealed that a substantial set of genes suppressed in bone metastases were highly enriched for promoter elements for the type I interferon (IFN) regulatory factor, Irf7, itself suppressed in mouse and human metastases. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE37975
ID:
200037975
9.

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape mechanisms

(Submitter supplied) Breast cancer metastasis to bone is a critical determinant of long-term survival after treatment of primary tumors. We used a mouse model of spontaneous bone metastasis to determine new molecular mechanisms. Differential transcriptome comparisons of primary and metastatic tumor cells revealed that a substantial set of genes suppressed in bone metastases were highly enriched for promoter elements for the type I interferon (IFN) regulatory factor, Irf7, itself suppressed in mouse and human metastases. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
6 Samples
Download data: TXT
Series
Accession:
GSE37828
ID:
200037828
10.

Transcription Factor Promyelocytic Leukemia Zinc Finger Protein regulates Interferon Stimulated Gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL8580 GPL8281
19 Samples
Download data: GPR
Series
Accession:
GSE16197
ID:
200016197
11.

Differential IFNa-stimulated gene expression profiles in PLZF-inducible U937T monocyte cells

(Submitter supplied) Sensitivity to Interferon (IFN) is determined by a complex coordination of genetic and environmental factors. A previous experiment using two renal cancer cell lines differing markedly in their response to IFN were analyzed for their ISG profiles in order to determine gene expression changes associated with IFN sensitivity (Holko M, Williams BR. Functional annotation of IFN-alpha-stimulated gene expression profiles from sensitive and resistant renal cell carcinoma cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8580
7 Samples
Download data: GPR
Series
Accession:
GSE16196
ID:
200016196
12.

IFN-alpha Stimulated Gene Expression in Sensitive and Resistant Renal Cell Carcinoma Cell Lines

(Submitter supplied) The antiproliferative, antiviral, and immunomodulatory properties of interferons (IFNs) have led to its therapeutic implementation. IFNs effects are mediated by a complex network of signal transducers, culminating in IFN-stimulated gene (ISG) induction. This complexity leads to diverse clinical responses to IFN, from no response to complete regression of disease. Elucidation of ISG induction patterns is, therefore, essential to understand and maximize its therapeutic potential. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8281
12 Samples
Download data: GPR
Series
Accession:
GSE15193
ID:
200015193
13.

The effect of MEK inhibition on transcription in melanoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
76 Samples
Download data: TXT
Series
Accession:
GSE51115
ID:
200051115
14.

The effect of MEK inhibition, Interferon beta, and their combination on transcription in melanoma

(Submitter supplied) We examined the transcriptional effect of interferon beta, MEK inhibition or their combination on 6 melanoma cell lines 3 cell lines have high basal acitvity of the interferon pathway, and 3 have low basal activity
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
24 Samples
Download data: TXT
Series
Accession:
GSE51114
ID:
200051114
15.

The effect of MEK inhibition on transcription in melanoma [Batch 2]

(Submitter supplied) In order to reveal the downstream targets of MAPK in melanoma, we measured the expression of 14 melanoma cell lines pre and post MEK inhibition
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
28 Samples
Download data: TXT
Series
Accession:
GSE51113
ID:
200051113
16.

The effect of MEK inhibition on transcription in melanoma [Batch 1]

(Submitter supplied) In order to reveal the downstream targets of MAPK in melanoma, we measured the expression of 12 melanoma cell lines pre and post MEK inhibition
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
24 Samples
Download data: TXT
Series
Accession:
GSE51051
ID:
200051051
17.

Single Cell sequencing of tumor infiltrating immune cells upon E2 treatment

(Submitter supplied) Estrogens (E2) has been shown to affect growth, differentiation and polarization of different immune cell types in different context. To understand how E2 treatment affects immune microenvironment during cancer (melanoma) progression, we profiled tumor infiltration immune cells from placebo and E2 treated tumors isolated from female mTyrCreERT2;BrafCA/WT;Ptenf/f. We identified diverse immune cell types and their underlying transcriptomic changes that are manifest upon E2 treatment in the tumor microenvironment.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE171403
ID:
200171403
18.

LNK suppresses interferon signaling in M202 melanoma cells

(Submitter supplied) LNK attenuates IFN-γ (2,000 U/ml, 24 hours) induced gene expression in M202 melanoma cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
4 Samples
Download data: IDAT, LOCS, TIFF, XML
Series
Accession:
GSE127965
ID:
200127965
19.

Force expression LNK suppresses interferon Gamma signaling

(Submitter supplied) LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses interferon (IFN) induced cell cycle arrest and cell apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
4 Samples
Download data: BW
Series
Accession:
GSE127764
ID:
200127764
20.

LNK suppresses interferon signaling in melanoma

(Submitter supplied) LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth and survival in adverse conditions. Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses interferon (IFN) induced cell cycle arrest and cell apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23227
6 Samples
Download data: BW
Series
Accession:
GSE127333
ID:
200127333
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