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Links from GEO DataSets

Items: 20

1.

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE6966
ID:
200006966
2.

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers (430)

(Submitter supplied) The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver to catalog genes expressed by liver progenitor cells. These cells, known as Bipotential Mouse Embryonic Liver (BMEL) cells, proliferate in an undifferentiated state and are capable of differentiating into hepatocyte-like and cholangiocyte-like cells in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE6957
ID:
200006957
3.

Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers (430A)

(Submitter supplied) The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver to catalog genes expressed by liver progenitor cells. These cells, known as Bipotential Mouse Embryonic Liver (BMEL) cells, proliferate in an undifferentiated state and are capable of differentiating into hepatocyte-like and cholangiocyte-like cells in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
12 Samples
Download data: CEL
Series
Accession:
GSE6942
ID:
200006942
4.

Search for microRNAs under the control of Grainyhead like-2

(Submitter supplied) Compare microRNA expression profile of HPPL (bipotential liver progenitor cell line) overexpressing Grhl2 with that of the control
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL19369
2 Samples
Download data: TXT
Series
Accession:
GSE62862
ID:
200062862
5.

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice

(Submitter supplied) The molecular identification of adult hepatic stem/progenitor cells has been hampered by the lack of truly specific markers. To isolate putative adult liver progenitor cells, we used cell surface-marking antibodies, including MIC1-1C3, to isolate subpopulations of liver cells from normal adult mice or those undergoing an oval cell response and tested their capacity to form bilineage colonies in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
16 Samples
Download data: TXT
Series
Accession:
GSE29121
ID:
200029121
6.

A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

(Submitter supplied) How the bi-potential hepatoblasts differentiate into hepatocytes and cholangiocytes remains unclear. Here, using single-cell transcriptomic analysis of hepatoblasts, hepatocytes, and cholangiocytes sorted from E10.5 to E17.5 mouse embryos, we found that hepatoblast-to-hepatocyte differentiation occurred gradually followed a linear default pathway. As more cells became fully differentiated hepatocytes, the number of proliferating cells decreased. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL13112
547 Samples
Download data: TXT
Series
Accession:
GSE90047
ID:
200090047
7.

RLSC and MMH-D3 cell lines

(Submitter supplied) Increasing evidence provide support that the mammalian liver contains stem/progenitor cells, but their molecular phenotype, embryological derivation, cell biology as well as of their role in the liver cell turnover and regeneration remain to be further clarified. We report the isolation, characterization and reproducible establishment in line of a resident liver stem cell (RLSC) with immunophenotype and differentiative potential distinct from other previously reported liver precursor/stem cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3520
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE7038
ID:
200007038
8.
Full record GDS3520

Resident liver stem cell lines

Analysis of the resident liver stem cell (RLSCs) lines MetE14/3 and WTE14/1. Results provide insight into the molecular phenotype of RLSCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 cell line, 2 cell type sets
Platform:
GPL1261
Series:
GSE7038
4 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS3520
ID:
3520
9.

Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells

(Submitter supplied) We describe that Hnf1α and Foxa3 dramatically facilitate the robust generation of iHepSCs. Notably, the prolonged in vitro culture of Hnf1α and Foxa3 derived iHepSCs induce Notch signaling-mediated secondary conversion into cholangiocyte progenitor-like cells displaying the dramatically enhanced differentiation capacity into the mature cholangiocytes in vitro and in vivo. Our study provides the novel two-step approach for obtaining cholangiocyte progenitor-like cells using defined factors.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
7 Samples
Download data: TXT
Series
Accession:
GSE97507
ID:
200097507
10.

Foxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential

(Submitter supplied) The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice with 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet led to an increase of the percentage of YFP-labeled Foxl1+ cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL4134 GPL10333
43 Samples
Download data: TXT
Series
Accession:
GSE28892
ID:
200028892
11.

Foxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential - Differentiated vs Primary

(Submitter supplied) The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice with 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet led to an increase of the percentage of YFP-labeled Foxl1+ cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
17 Samples
Download data: TXT
Series
Accession:
GSE28891
ID:
200028891
12.

Foxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential - Time Course

(Submitter supplied) The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice with 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet led to an increase of the percentage of YFP-labeled Foxl1+ cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
26 Samples
Download data: TXT
Series
Accession:
GSE28890
ID:
200028890
13.

Gene-level differential expression analysis in hepatoblasts with or without mmu-miR-337-3p overexpression

(Submitter supplied) Impact of mmu-miR-337-3p on the global gene expression in murine hepatoblasts. We used microarrays to identify the genes controlled by mmu-miR-337-3p in in vitro cultured hepatoblasts. We identified distinct classes of up-regulated / down-regulated genes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE99890
ID:
200099890
14.

Generation of functional cholangiocytes from human pluripotent stem cells and HepaRG cells

(Submitter supplied) Gene expression profile analysis allowed to identify a panel of genes and pathways characteristic of hESC-and HepaRG-derived cholangiocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14550
28 Samples
Download data: TXT
Series
Accession:
GSE51791
ID:
200051791
15.

Murine Hepatoblasts

(Submitter supplied) The homeobox transcription factor Prox1 is expressed in embryonic hepatoblasts and remains expressed in adult hepatocytes. Prox1-null mice show severe deficiencies of liver development, but the underlying mechanisms are unknown. We studied the effects of Prox1 on the transcriptional profile of embryonic day-14 (ED14) met-murine-hepatocytes (ED14-MMH). These immortalized murine hepatoblasts express numerous hepatoblast markers, but not Prox1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
6 Samples
Download data: GPR
Series
Accession:
GSE7867
ID:
200007867
16.

Single-cell transcriptome analysis of mouse fetal livers from different developmental stages

(Submitter supplied) We employed marker-free single-cell RNA-Seq to characterize comprehensive transcriptional profiles of 507 cells from seven stages between embryonic day 11.5 and postnatal day 2.5 during mouse liver development. Our data demonstrated the existence of two types of stem/progenitor cells with distinct molecular patterns during liver development. Both types of cells exhibit heterogeneity of transcriptional program within each cell population, suggesting they be in distinct status of self-renewal, cell proliferation and different sub-stages of differentiation and maturation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
507 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE87795
ID:
200087795
17.

A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver.

(Submitter supplied) Cells with slow proliferation kinetics that retain the nuclear label over long time periods – the label-retaining cells (LRCs) – represent multipotent stem cells in a number of adult tissues. Since the identity of liver LRCs (LLRCs) had remained elusive we utilized a genetic approach to reveal LLRCs in normal non-injured livers and characterized their regenerative properties in vivo and in culture. We found that LLRCs were located in biliary vessels and participated in the regeneration of biliary but not hepatocyte injury. In culture experiments the sorted LLRCs displayed an enhanced self-renewal capacity but a unipotent biliary differentiation potential. Transcriptome analysis revealed a unique set of tumorigenesis- and nervous system-related genes upregulated in LLRCs when compared to non-LRC cholangiocytes. We conclude that the LLRCs established during the normal morphogenesis of the liver do not represent a multipotent primitive somatic stem cell population but act as unipotent biliary progenitor cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: TXT
Series
Accession:
GSE90160
ID:
200090160
18.

Human hepatocyte metaplasia in injured humanized mouse livers

(Submitter supplied) The goal of this experiment was to test whether human hepatocytes could give rise to biliary-like progenitor cells in an in vivo context. Here Fah-/- Il2ry-/- Rag2-/-NOD mouse livers were humanized with human hepatocytes. Only hepatocytes engraft in the Fah-/- mouse at detectable levels in this model. Then animals were given chronic liver injury with 0.1% ddc. After injury we measured human-specific transcripts to determine whether the phenotype of the human cells had changed. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL13112 GPL16512
13 Samples
Download data: TXT
Series
Accession:
GSE58679
ID:
200058679
19.

Hepatocyte ductal metaplasia in chronic mouse liver injury

(Submitter supplied) Expression profiling of hepatocytes-derived ductal cells with properties intermediate between mature hepatocytes and cholangiocytes
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
14 Samples
Download data: TXT
Series
Accession:
GSE55552
ID:
200055552
20.

Gene expression analysis of reprogrammed pancreatic cells, liver and pancreas

(Submitter supplied) We recently generated pancreatic progenitor cells (so-called TiPP cells, TGIF2-induced pancreatic progenitors) by reprogramming adult hepatic cells (HEP). To analyze the extent of reprogramming and to investigate the mechanisms underlying liver-to-pancreas conversion, we analyzed the changes in gene expression in TiPP cells at two time points (day 14 and day 30 after transduction) compared to control HEP cells, mouse embryonic pancreas (E14.5) and adult pancreas and liver tissues.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
18 Samples
Download data: TXT
Series
Accession:
GSE54591
ID:
200054591
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