GEO DataSets

(Submitter supplied) Gene expression profiling of early stage cervical cancer tumours with and without lymph node metastasis, in order to predict lymph node metastasis before treatment. Subsequently, comparing gene expression profiles between healthy cervical tissue and early stage cervical cancer tissue. Keywords: Disease stage analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1708

45 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles of oral tongue squamous cell carcinoma tissues. Keywords: human tongue cancer, brachytherapy, biopsy sample, primary tissues

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2891

98 Samples

Download data

(Submitter supplied) Samples were taken from colorectal cancers in surgically resected specimens in 89 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be used for molecular markers for predicting lymph node metastases. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

89 Samples

Download data

(Submitter supplied) Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node could be predicted by a gene expression signature of the primary tumor. A total of 18 OSCCs were characterized for gene expression by hybridizing RNA to Affymetrix U133A gene chips. Genes with differential expression were identified using a permutation technique and verified by quantitative RT-PCR and immunohistochemistry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1062

Platform:

GPL96

27 Samples

Download data: CEL

Expression profiling of 18 primary squamous cell carcinomas of the oral cavity with or without lymph node metastasis. Expression in lymph node metastasis also examined. Results used to identify gene expression signature in primary tumors that indicates the presence of lymph node metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 tissue sets

Platform:

GPL96

Series:

GSE2280

27 Samples

Download data: CEL

(Submitter supplied) Using gene expression microarrays, we tested whether lung SCCs that have metastasised to loco-regional lymph nodes (N1/2m) are different to those that directly invade and involve local nodes (N1d). Using 22,323 element microarrays, a non-parametric test identified 126 genes/transcripts that discriminated between N0 (n=35) and N1/2m (n=16) tumours (Wilcoxon-Mann-Whitney U test, P<0.01). Hiearchical clustering of all 59 tumours (including 8 N1d tumours) demonstrated the N1d tumours clustered with the N0 tumours rather than the N1/2m tumours. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3877

59 Samples

Download data

(Submitter supplied) Lymph node vs. tonsil Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1618

Platform:

GPL96

20 Samples

Download data: CEL, EXP

Analysis of lymph node (sinuses) and tonsil (no sinuses), highly similar secondary lymphoid organs. Metastatic tumor cells are preferentially arrested in the lymph node sinuses. Results identify signature genes that are prime candidates for mediating adhesion of tumor cells to sinusoidal cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL96

Series:

GSE2665

20 Samples

Download data: CEL, EXP

(Submitter supplied) Lymph node involvement is the most important prognostic factor in breast cancer, but little is known about the underlying molecular changes. First, to identify a molecular signature associated with nodal metastasis, gene expression analysis was performed on a homogeneous group of 96 primary breast tumors, balanced for lymph node involvement. Each tumor was diagnosed as a poorly differentiated, estrogen positive, her2-neu negative invasive ductal cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

116 Samples

Download data: CEL

(Submitter supplied) Purpose: To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer. Experimental Design: A total of 33 biopsies were obtained from 11 patients, sampling between two and five different areas for each tumor.The extracted RNAwas hybridized onto the Affymetrix U133 Plus 2.0 oligonucleotide chip. The variance of expression within a patient (W), between patients (B) and the total variance (T =W + B) were calculated for each ProbeSet, and the ratio W/T was used as a measure of intratumor heterogeneity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2416

Platform:

GPL570

33 Samples

Download data: CEL, EXP

Analysis of 33 biopsies from 11 cervical cancer patients. Biopsies were obtained from 2 to 5 different areas of each tumor. Results provide insight into the extent of intratumor heterogeneity in gene expression in cervical cancer patients.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 11 individual sets

Platform:

GPL570

Series:

GSE5787

33 Samples

Download data: CEL, EXP

(Submitter supplied) Purpose: Presence of pelvic lymph node metastases is the main prognostic factor in early stage cervical cancer patients, primarily treated with surgery. Aim of this study was to identify cellular tumor pathways associated with pelvic lymph node metastasis in early stage cervical cancer. Experimental Design: Gene expression profiles (Affymetrix U133 plus 2.0) of 20 patients with negative (N0) and 19 with positive lymph nodes (N+), were compared with gene sets that represent all 285 presently available pathway signatures. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4664

Platform:

GPL570

39 Samples

Download data: CEL

Analysis of primary cervical cancer tissue of patients with pelvic lymph node metastasis. Positive lymph nodes are an important prognostic factor in early-stage cervical cancer patients. Results provide insight into the molecular basis of pelvic lymph node metastasis in early cervical cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE26511

39 Samples

Download data: CEL

(Submitter supplied) We compared the prediction powers for disease recurrence between gene set prognostic model and clinical prognostic model developed in a single large population to see whether genetic quantitative approach will have significant prognostic role in early cervical cancer patients who underwent radical hysterectomy with or without adjuvant therapies. Gene set model to predict disease free survival of early cervical cancer was developed using DASL assay dataset from the cohort of early cervical cancer patients who were treated with radical surgery with or without adjuvant therapies at the Samsung Medical Center of Sungkyunkwan University School of Medicine in Seoul, Korea, between January 2002 and September 2008. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14951

300 Samples

Download data: TXT