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Links from GEO DataSets

Items: 20

1.

Contribution of Foxp3 to the Treg signature

(Submitter supplied) The transcription factor Foxp3 is usually considered the master regulator for the CD4+CD25+ "Treg" lineage, which plays a key role in controlling immune and autoimmune responses, and is characterized by a unique transcriptional signature. We have performed a meta-analysis of this signature in Treg cells in several conditions to delineate the elements that can be ascribed to T cell activation, TGFbeta signaling, or Foxp3 itself. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
52 Samples
Download data: CEL
Series
Accession:
GSE7460
ID:
200007460
2.

Foxp3 ablation in peripheral mature regulatory T cells

(Submitter supplied) Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Keywords: genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2525
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE6681
ID:
200006681
3.
Full record GDS2525

Foxp3 ablation effect on mature regulatory T cells

Analysis of mature regulatory T cells (Treg) ablated for the transcription factor Foxp3. Foxp3 is required for the development of Treg cells. Results provide insight into the role of Foxp3 in maintaining the transcriptional and functional program established during Treg cell development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL1261
Series:
GSE6681
4 Samples
Download data: CEL
DataSet
Accession:
GDS2525
ID:
2525
4.

Regulatory T cell lineage specification by Foxp3

(Submitter supplied) Examination of CD4+ T cells from Foxp3-GFP knock-in mice. Aim is to understand the genetic program governed by Foxp3 in T cells by comparison of CD4 T cells subdivided into four groups based on expression of Foxp3 and CD25. Keywords = regulatory T cells Keywords = Foxp3 Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1113
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE2389
ID:
200002389
5.
Full record GDS1113

CD4+ T cells expressing transcription factor Foxp3 and various amounts of CD25

Analysis of CD4+/CD25lo, CD4+/CD25+, and CD4+/CD25hi T cells expressing the forkhead transcription factor Foxp3. FACS used to sort CD4+ cells based on Foxp3 GFP fusion protein and CD25 expression. Results provide insight into the role of Foxp3 in regulatory T cell development and function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 cell type, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE2389
4 Samples
Download data: CEL
DataSet
Accession:
GDS1113
ID:
1113
6.

Genome wide FOXP3 binding sites in human cord blood derived CD4+CD25+ natural T regulatory cells (nTreg)

(Submitter supplied) FOXP3 is essential for the stability and function of nTReg. We have characterised the FOXP3-dependent cis-regulatory network through a combination of whole genome ChIP-on-chip and transcriptional profiling of primary human nTreg cells . Human nTreg cells were isolated from cord blood and expanded ex vivo (day9). These analyses identified approximately 8,000 high quality FOXP3 binding sites the majority (85%) of which were located in proximity to annotated genes . more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
7 related Platforms
7 Samples
Download data: BED, CEL
Series
Accession:
GSE20995
ID:
200020995
7.

Expression data from cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, both while resting & after stimulation

(Submitter supplied) Here we compare the effects of stimulation on cord blood derived CD4+ CD25+ (Treg) and CD4+ CD25- (Thelper) cells, isolated by MACS protocols & expanded in vitro using dynabeads. Expansion was carried out at a ratio of 3 beads/cell in the presence of 1000units/ml of recombinant human IL2 for 8 days, followed by 3 days of culture without beads. RNA was extracted from resting cells on day 4 after expansion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10200
18 Samples
Download data: CEL
Series
Accession:
GSE20934
ID:
200020934
8.

Foxp3-dependent programme of regulatory T-cell differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE7773
ID:
200007773
9.

Gene expression in thymic CD4 T cells: effects of Foxp3

(Submitter supplied) This data set is comprised of all thymic T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R thymocytes. Keywords: cell type comparison, development
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE7770
ID:
200007770
10.

Gene expression in peripheral cells: effects of Foxp3 and PDE3B

(Submitter supplied) This data set is comprised of all peripheral (pooled lymph nodes and spleen) T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells from mice treated with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressing retroviral vectors (after transfer into recipient mice). Keywords: cell type comparison, response to growth factor, genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE7280
ID:
200007280
11.

Microarray analysis of Cbfb-deficient regulatory T cells

(Submitter supplied) Gene expression profiles of Cbfb-deficient and control Treg cells were compared. Abstract: Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here we showed that Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyper-production of IgE. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3577
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE18148
ID:
200018148
12.
Full record GDS3577

Cbfbeta deficiency effect on regulatory T cells

Analysis of regulatory T cells lacking Cbfbeta. Cbfbeta is a cofactor for the Runx family of transcription factors. Results provide insight into the role of the Runx1-Cbfbeta transcription complex in regulatory T cell function.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE18148
6 Samples
Download data: CEL
DataSet
Accession:
GDS3577
ID:
3577
13.

Comparison of stable human Treg and Th clones by transcriptional profiling - experiment I

(Submitter supplied) The aim of this work was to identify functional features that are specific of human Treg cells, through the identification of genes that are differentially expressed: 1/ in activated Treg clones versus activated Thelper clones; 2/ in Th clones activated in the presence versus the absence of TGFb; 3/ in suppressed Th clones, i.e. Th clones activated in the presence of Treg clones, versus controls. Keywords: TCR activation
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
24 Samples
Download data: CEL
Series
Accession:
GSE14330
ID:
200014330
14.

Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression

(Submitter supplied) CD4+CD25+FOXP3+ regulatory T cells (Treg) are pivotal for peripheral self-tolerance. They prevent immune responses to auto- and alloantigens and are thus under close scrutiny as cellular therapeutics for autoimmune diseases and the prevention or treatment of alloresponses after organ or stem cell transplantation. We previously showed that human Treg cells with a memory cell phenotype, but not those with a naïve phenotype, rapidly down-regulate expression of the lineage-defining transcription factor forkhead box P3 (FOXP3) upon in vitro expansion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
10 Samples
Download data: TXT
Series
Accession:
GSE26190
ID:
200026190
15.

AKT regulates de novo induction of Foxp3

(Submitter supplied) The CD4+Foxp3+ regulatory T cells play an essential role in maintaining tolerance via their suppressive function on conventional T cells. The intracellular signaling pathways that regulate Foxp3 expression are largely unknown. In this study we describe a novel inhibitory role for AKT in regulating de novo induction of Foxp3 both in vivo and in vitro. A constitutively active allele of AKT significantly diminished TGF-â induced Foxp3 induction via a rapamycin-sensitive pathway, establishing a role for the AKT-mTOR axis in Treg cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE7596
ID:
200007596
16.

Gene expression profiles of CD4SP Foxp3GFP-CD25+ Treg precursors and Foxp3GFP-CD25- thymocytes

(Submitter supplied) We investigated at which stage of maturation commitment to a stable Foxp3-expressing phenotype takes place. We assessed stability of Foxp3 expression in thymic Foxp3+ Treg subsets of different maturity, defined by CD24 expression. Next we compared gene expression profiles of Foxp3+ Treg subsets (+) of different maturity (24lo, 24int, 24hi) and could identify a set of genes that were specifically up or downregulated in Foxp3+ Tregs, but not in Foxp3- conventional T cells, in a maturation-dependent manner.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
27 Samples
Download data: CEL
Series
Accession:
GSE42021
ID:
200042021
17.

RNA-seq analysis of transcriptomes of thymus derived tTreg cells and the exFoxp3 precursor cells

(Submitter supplied) To determine the phenotype of the precursor of exFoxp3 cells and find the signals that affect the stability of tTreg cells, we analysis the transcriptomes of epigenetic stable thymus derived tTreg cells and the exFoxp3 precursor cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: TXT
Series
Accession:
GSE93856
ID:
200093856
18.

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance [ATAC-Seq]

(Submitter supplied) STAT5 transcription factor activation downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic outputs of IL-2R signaling, it is unclear whether STAT5 acts directly on the Foxp3 locus to promote its expression . Here, we report that IL-2 – STAT5 signaling converged on an enhancer (CNS4) during Foxp3 induction. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
9 Samples
Download data: BW
Series
Accession:
GSE169043
ID:
200169043
19.

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

(Submitter supplied) STAT5 transcription factor activation downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic outputs of IL-2R signaling, it is unclear whether STAT5 acts directly on the Foxp3 locus to promote its expression . Here, we report that IL-2 – STAT5 signaling converged on an enhancer (CNS4) during Foxp3 induction. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21493
4 Samples
Download data: BW
Series
Accession:
GSE168942
ID:
200168942
20.

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance [RNA-seq]

(Submitter supplied) STAT5 transcription factor activation downstream of the Interleukin-2 receptor (IL-2R) induces expression of Foxp3, a critical step in the differentiation of regulatory T (Treg) cells. Due to the pleiotropic outputs of IL-2R signaling, it is unclear whether STAT5 acts directly on the Foxp3 locus to promote its expression . Here, we report that IL-2 – STAT5 signaling converged on an enhancer (CNS4) during Foxp3 induction. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: CSV
Series
Accession:
GSE168829
ID:
200168829
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