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Links from GEO DataSets

Items: 20

1.

Brown versus white tissue adipose selective genes

(Submitter supplied) The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Keywords: tissue comparison from mice
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2813
Platform:
GPL1261
6 Samples
Download data: CEL, CHP, DCP, TXT
Series
Accession:
GSE8044
ID:
200008044
2.
Full record GDS2813

Brown and white adipose tissues

Comparison of brown and white adipose tissues. Brown fat cells are specialized to dissipate energy and can counteract obesity. Results provide insight into the molecular mechanisms controlling brown fat cell determination.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL1261
Series:
GSE8044
6 Samples
Download data: CEL, CHP, DCP, TXT
3.

Expression data from white adipose tissue of Perilipin A transgenic mice

(Submitter supplied) Perilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Adipocyte specific overexpression of PeriA caused resistance to diet-induced obesity and resulted in improved insulin sensitivity. In order to better understand the biological basis for this observed phenotype we performed DNA microarray analysis on white adipose tissue (WAT) from PeriA transgenic (Tg) and control wildtype (WT) mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE21754
ID:
200021754
4.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

(Submitter supplied) Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2123
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5042
ID:
200005042
5.

Expression of the brown fat thermogenic gene program requires PGC-1alpha

(Submitter supplied) To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severly reduced the induction of thermogenic genes. In order to assess the specific requirement for PGC-1α in the global transcriptional response to cAMP, we used Affymetrix arrays to compare the sets of genes induced in response to a 4 hr dbcAMP treatment in differentiated wt and KO cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2149
Platform:
GPL1261
8 Samples
Download data
Series
Accession:
GSE5041
ID:
200005041
6.
Full record GDS2149

PGC-1alpha null brown adipocyte response to cAMP

Analysis of PGC-1alpha null brown adipocytes treated with cAMP for 4 hours. PGC-1alpha is required for the thermogenic function of brown fat cells, and cAMP plays a role in thermogenesis. Results provide insight into the role of PGC-1alpha in the global transcriptional response to cAMP.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5041
8 Samples
Download data
DataSet
Accession:
GDS2149
ID:
2149
7.
Full record GDS2123

Brown fat cell response to PGC-1alpha and PGC-1beta deficiency

Analysis of brown fat cells lacking PGC-1alpha or both PGC-1alpha and PGC-1beta. PGC-1alpha is required for the thermogenic function of brown fat cells, and PGC-1beta is the closest homolog of PGC-1alpha. Results provide insight into the specific roles of PGC-1alpha and PGC-1beta in brown fat cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5042
6 Samples
Download data
DataSet
Accession:
GDS2123
ID:
2123
8.

Remodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation

(Submitter supplied) The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription program of mitochondrial biogenesis and thermogenesis. In the present study, we evaluated the role of NT-PGC-1α in brown adipocyte energy metabolism by genome-wide profiling of NT-PGC-1α-responsive genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
4 Samples
Download data: TXT
Series
Accession:
GSE71774
ID:
200071774
9.

Gene expression profiles of ASK1-deficient adipose tissues

(Submitter supplied) To elucidate the potential function of ASK1 in adipose tissues, microarray analysis was performed using iBAT and eWAT. Tissue samples were collected from 10-week-old male mice, and RNA samples derived from three individuals were pooled to analyze. These data provide novel insights into the physiological functions of ASK1.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
4 Samples
Download data: TXT
Series
Accession:
GSE76660
ID:
200076660
10.

Expression data fom human capillary network-derived cells before and after adipogenic differentation, and after chronic adenylate cyclase activation of differentiated cells

(Submitter supplied) Progenitors in human vasculature expanded in-vitro were differentiated with adipogenic cocktail for 12 days, following which they were stimulated with forskolin for 7 days Microarrays were used to detail the program of differentiation of thermogenic human adipose cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE73385
ID:
200073385
11.

PPARg agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein

(Submitter supplied) Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been shown to induce the browning of white adipocytes; however, the underlying mechanisms remain unclear. Here we show that PPARγ ligands require full agonism to induce a brown fat gene program preferentially in subcutaneous white adipose. These effects require expression of PRDM16, a factor that controls the development of classical brown fat. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4021
Platform:
GPL8321
8 Samples
Download data: CEL
Series
Accession:
GSE35011
ID:
200035011
12.
Full record GDS4021

Rosiglitazone effect on PRDM16-deficient inguinal white adipose tissue: stromal-vascular cells

Analysis of SV cells isolated from PRDM16-depleted inguinal white adipose tissue (WAT) treated with rosiglitazone. Antidiabetic PPARγ ligand drugs, such as rosiglitazone, activate a browning of WAT. Results provide insight into molecular mechanisms underlying white-to-brown fat conversion.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE35011
8 Samples
Download data: CEL
13.

Expression data from C2C12 myoblasts transduced with PRDM16 or vector

(Submitter supplied) PRDM16 is a 140 kDa transcriptional coregulatory protein. PRDM16 has been shown to function as a bi-directional switch in brown fat cell fate by stimulating the development of brown fat cells from myf-5 positive myoblastic precursors. We used microarrays to detail the global programme of gene expression underlying the myoblasts-brown fat conversion induced by PRDM16.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE15895
ID:
200015895
14.

Programming human pluripotent stem cells into adipocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6244 GPL570 GPL13607
58 Samples
Download data: CEL, TXT
Series
Accession:
GSE30041
ID:
200030041
15.

Programming human pluripotent stem cells into adipocytes [Agilent]

(Submitter supplied) The utility of human pluripotent stem cells as a tool for understanding disease and as a renewable source of cells for transplantation therapies is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human pluripotent stem cells into adipocytes. We found that inducible expression of PPARG2 in pluripotent stem cell-derived mesenchymal progenitor cells programmed their development towards an adipocyte cell fate. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
24 Samples
Download data: TXT
Series
Accession:
GSE30039
ID:
200030039
16.

Programming human pluripotent stem cells into adipocytes [Affymetrix]

(Submitter supplied) The utility of human pluripotent stem cells as a tool for understanding disease and as a renewable source of cells for transplantation therapies is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation of human pluripotent stem cells into adipocytes. We found that inducible expression of PPARG2 in pluripotent stem cell-derived mesenchymal progenitor cells programmed their development towards an adipocyte cell fate. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL6244
34 Samples
Download data: CEL, TXT
Series
Accession:
GSE30038
ID:
200030038
17.

Expression Profiles of miRNAs in brown fat of mice at room temperature and cold exposure (8C)

(Submitter supplied) microRNAs levels were measured in brown adipose tissue of male C57Bl6N mice that were kept at RT or during cold exposure (8°C) for 24 hrs. Several miRNAs including myomirs were identified to be regulated in response to cold.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL7732
8 Samples
Download data: TXT
Series
Accession:
GSE41306
ID:
200041306
18.

Sex-dependent effects of Siah2 on brown adipose tissue whitening and inflammation with a high fat diet

(Submitter supplied) The goal of this experiment was to examine the sex-dependent effect of Siah2 in brown adipose tissue
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6885 GPL6887
18 Samples
Download data: TXT
Series
Accession:
GSE123990
ID:
200123990
19.

Analysis of the differences in gene expression between wild type and Gpr120 knockout brown adipose tissue

(Submitter supplied) The goals were to investigate differences in gene expression between wild type and Gpr120 knockout mouse interscapular brown adipose tissue
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
11 Samples
Download data: TXT
Series
Accession:
GSE97145
ID:
200097145
20.

Gene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes

(Submitter supplied) Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4851
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE40280
ID:
200040280
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