Similar studies for GEO DataSets (Select 200008101) - GEO DataSets

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Items: 20

Select item 2000081011.

WT and irf3-/- macrophage response to WT L. monocytogenes

(Submitter supplied) Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
12 Samples

Download data: GPR

Series

Accession:: GSE8101

ID:: 200008101

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000081042.

Primary macrophage response to L. monocytogenes and bacteria-derived ligands

(Submitter supplied) Transcriptional profiling of macrophages (of various genetic backgrounds) infected with L. monocytogenes or transfected with purified ligands Keywords: Timecourse, cell type comparison, bacteria strain comparison, drug comparison, ligand comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
81 Samples

Download data: GPR

Series

Accession:: GSE8104

ID:: 200008104

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Select item 2000081033.

WT macrophage response to transfected bacterial ligands

(Submitter supplied) Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
8 Samples

Download data: GPR

Series

Accession:: GSE8103

ID:: 200008103

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Select item 2000081024.

WT macrophage response to WT L. monocytogenes, with or without CAPE treatment

(Submitter supplied) Transcriptional profiling of WT macrophages infected with WT L. monocytogenes for 180 minutes, with or without CAPE treatment Keywords: Drug comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
8 Samples

Download data: GPR

Series

Accession:: GSE8102

ID:: 200008102

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Select item 2000081005.

WT and myd88-/- macrophage response to WT and hly- L. monocytogenes

(Submitter supplied) Transcriptional profiling of WT and myd88-/- macrophages infected with WT and hly- L. monocytogenes for 30, 60, 120, or 180 minutes Keywords: Timecourse, cell type comparison, bacteria strain comparison.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL5137
53 Samples

Download data: GPR

Series

Accession:: GSE8100

ID:: 200008100

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Select item 2000039916.

Listeria host responses

(Submitter supplied) This logical set encompases several 8hr timecourses (0,1,2,4,8 hrs) and their replicates. All correspond to treatments of bone marrow derived macrophages. Abstract: Innate and adaptive immunity depends critically on host recognition of pathogen-associated molecules. Toll-like receptors (TLRs) are key mediators of pathogen surveillance at the cell or phagocytic vacuole surface. However, mechanisms underlying recognition of pathogens in other cellular compartments remain unclear, and responses elicited by cytosolic challenge are poorly characterized. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL3329 GPL3328
85 Samples

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Series

Accession:: GSE3991

ID:: 200003991

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Select item 2000101827.

MDP- and Pam3CSK4-induced genes in naïve and tolerant macrophages

(Submitter supplied) Most of the genes were self-tolerized by Pam3CSK4 and MDP but there was no or minimal cross-tolerization. The transcriptome induced via Nod2 stimulation is greatly expanded in TLR2-tolerant macrophages. Keywords: self and cross tolerance by MDP or Pam3CSK4

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
7 Samples

Download data: CEL

Series

Accession:: GSE10182

ID:: 200010182

Select item 2000293888.

H. pylori infection blocks DNA damage induced apoptosis by T4SS-dependent upregulation of miR-155

(Submitter supplied) The innate immune response against Helicobacter pylori is mainly controlled by pattern recognition receptors that lead to the up-regulation of pro-inflammatory cytokines. A new player in this field is the miR-155 being regulated by TLR ligands in monocytic derived cells influencing certain intracellular pathways by down-regulating targets involved in signaling and development. By using primary bone marrow derived macrophages (BMMs) from mice deficient in the key TLR signals the regulation of miR-155 was explored. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
4 Samples

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Series

Accession:: GSE29388

ID:: 200029388

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Select item 2000014059.

LPS-induced and E. coli-induced gene expression in wildtype and MyD88-/- mouse macrophages

(Submitter supplied) Comparison of gene expression in wildtype and MyD88-/- C57BL/6J mouse macrophages treated with 10 ng/mL LPS for 2 hours versus media treated control macrophages, and, wildtype and MyD88-/- C57BL/6J mouse macrophages treated with live E. coli bacteria (log phase; 1 bact per 1 macrophage) for 2 hours versus media treated control macrophages. Cells from 4 mice of each geneotype were used and each individual provided its own control. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS1705 GDS1706
Platform:: GPL1226
31 Samples

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Series

Accession:: GSE1405

ID:: 200001405

Select item 170610.

MyD88-deficient macrophage response to lipopolysaccharide and E. coli (dye swap)

Analysis of MyD88 null mutant macrophages treated with LPS or live E. coli. MyD88 transduces cell signaling events downstream of Toll-like receptors, a key component of host defense. Results suggest most of the host response to endotoxin or live bacteria is actually regulated independently of MyD88.

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:: GPL1226
Series:: GSE1405
15 Samples

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DataSet

Accession:: GDS1706

ID:: 1706

Select item 170511.

MyD88-deficient macrophage response to lipopolysaccharide and E. coli

Organism:: Mus musculus

Type:: Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:: GPL1226
Series:: GSE1405
16 Samples

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DataSet

Accession:: GDS1705

ID:: 1705

Select item 20005211512.

Gene expression profile in peritoneal macrophage infected with Listeria monocytogenes

(Submitter supplied) Several Toll-like receptors are activated by Listeria monocytogenes infection, resulting in the activation of MyD88 dependent signaling pathway. However, the negative role of MyD88 in gene expresson is unclear. To address this, we performed microarray analysis of mRNAs from WT or MyD88-/- peritoneal macrophages infected with Listeria monocytogenes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
3 Samples

Download data: CEL, CHP

Series

Accession:: GSE52115

ID:: 200052115

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Select item 20005180413.

Effect of W805EC nanoemulsion (NE) on global gene transcription in JawsII dendritic cells in vitro

(Submitter supplied) Nanoemulsion adjuvant affects immune gene expression in dendritic cells. Microarray was used to asses global changes in gene expression in JAWS II dendritic cells upon treatment with nanoemulsion (NE) adjuvant W805EC

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5601
Platform:: GPL1261
10 Samples

Download data: CEL, TXT

Series

Accession:: GSE51804

ID:: 200051804

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Select item 560114.

Nanoemulsion adjuvant W805EC effect on JAWS II dendritic cells: time course

Analysis of JAWS II DCs incubated with nanoemulsion (NE) adjuvant W805EC for up to 24 hrs. W805EC is an oil-in-water emulsion with nanodroplets similar in size to many viruses infecting the nasal mucosa. Results provide insight into the molecular basis of the adjuvant activity of W805EC NE in DCs.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 5 protocol, 2 time sets

Platform:: GPL1261
Series:: GSE51804
10 Samples

Download data: CEL

DataSet

Accession:: GDS5601

ID:: 5601

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20012949715.

Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase

(Submitter supplied) TLR activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades within the first hours after stimulation. Whether concurrent changes in the cellular metabolism that occur upon TLR activation influence the quality of the transcriptional responses remain unknown. Here we investigated how macrophages adopt their metabolism early after activation to regulate TLR-inducible gene induction. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: TXT

Series

Accession:: GSE129497

ID:: 200129497

PubMed Similar studies SRA Run Selector

Select item 20006466616.

Expression data from bone marrow-derived dendritic cells

(Submitter supplied) Dendritic cells are the sentinels of the innate immune system. We used global microarray analysis to identify genes which are regulated by Toll-like receptor signaling pathways.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
4 Samples

Download data: CEL

Series

Accession:: GSE64666

ID:: 200064666

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013342217.

Real-time quantitative PCR analysis of human gingiva epithelial cells exposed to microbial biofilms

(Submitter supplied) An organotypic gingiva model RHG was constructed by immortalized human gingiva cell lines (keratinocytes and fibroblasts) in vitro. The RHG model was exposed to either control medium or one of the three multi-species oral biofilms (commensal, gingivitis and cariogenic) for 24 hours. We used Qiagen RT² Profiler PCR array to analyse the expression of genes which are related to Toll-like receptor signaling pathway from the unexposed (control) and differently exposed (test) keratinocyte layer of the RHG model. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL24875
4 Samples

Download data: TXT

Series

Accession:: GSE133422

ID:: 200133422

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Select item 20003912918.

A TLR- and non-TLR-mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade

(Submitter supplied) Lentiviral vector (LV)-mediated gene transfer is a promising method of gene therapy. We previously reported that systemic injection of LV triggers a transient inflammatory response. Here, we carried out studies to better characterize this response, and to develop a strategy to overcome the effects of interferon (IFN) on LV-mediated gene transfer. We profiled gene expression in the liver after LV administration using deep-sequencing, and identified several innate response pathways. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE39129

ID:: 200039129

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001850019.

Mast cells in response to some pathogens elicit a transcriptional program devoid of type I IFN response

(Submitter supplied) Although mast cells elicit proinflammatory and type I IFN responses upon VSV infection, in response to L.monocytogenes (L.m) or S. Typhimurium (S.t), such cells elicit a transcriptional program devoid of type I IFN response. Balanced induction of proinflamatory and type I interferon (IFN) responses upon activation of Toll like receptors (TLRs) determines the outcome of microbial infections and the pathogenesis of autoimmune and other inflammatory diseases. more...