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Links from GEO DataSets

Items: 7

1.

Smad1/5/8 mutant granulosa cell tumor gene expression

(Submitter supplied) The objective of this study was to understand the gene expression changes during granulosa cell tumor development in Smad1/5/8 mutant ovaries. Keywords: Microarray analysis, gene expression
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE8156
ID:
200008156
2.

Comparsion of Smad1 and Smad5 Dependent Transcript Profiles in Zebrafish

(Submitter supplied) The BMP signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor-regulated Smads, including Smad1 and Smad5. Here we use loss-of-function approaches in zebrafish to compare the roles of Smad1 and Smad5 during embryonic hematopoiesis. Microarray experiments revealed that the two proteins regulate redundantly the key initiators of the hemato-vascular program, including scl, lmo2, and gfi1. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platforms:
GPL5783 GPL5746
9 Samples
Download data
Series
Accession:
GSE8903
ID:
200008903
3.

Gene expression profiling on innervated and denervated muscles of Smad4 KO and control mice.

(Submitter supplied) To identify novel atrophy-related genes, which are controlled by BMP signaling, we performed gene expression profiling on innervated and 14 days denervated muscles of Smad4 knockout and control mice, focusing on genes that were differentially upregulated in denervated Smad4-/- muscles compared to controls. Among the different genes our attention was attracted by a gene that encodes for a novel f-box protein (Fbxo30) belonging to the SCF complex family of the ubiquitin ligases. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE49826
ID:
200049826
4.

Distinct and Overlapping Gene Regulatory Networks in BMP- and HDAC-Controlled Cell Fate Determination in the Embryonic Forebrain

(Submitter supplied) Both bone morphogenetic proteins (BMPs) and histone deacetylases (HDACs) have previously been established to play a role in the development of the three major cell types of the central nervous system: neurons, astrocytes, and oligodendrocytes. We have previously established a connection between these two protein families, showing that HDACs suppress BMP-promoted astrogliogenesis in the embryonic striatum. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE31792
ID:
200031792
5.

Gene expression profiling of Smad1/5 cKO and Acvr2a cKO mice

(Submitter supplied) We generated mice with single or double conditional inactivation of SMAD1 and SMAD5 using progesterone receptor (PR) cre (Smad1flox/flox;Smad5flox/flox;Pgr-cre+/-, or “Smad1/5 cKO”). Female mice with single SMAD1 or SMAD5 deletion were subfertile, whereas Smad1/5 cKO were infertile and had no visible implantation sites at 4.5 days post-coitum (dpc), indicating functional redundancy of SMAD1 and SMAD5. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
11 Samples
Download data: TXT
Series
Accession:
GSE152675
ID:
200152675
6.

Smad5 acts as an intracellular pH messenger and maintains bioenergetic homoeostasis

(Submitter supplied) we report here that Smad5 acts as a pHi messenger and maintains bioenergetic homeostasis of a cell by regulating cytoplasmic metabolic machinery
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: TXT
Series
Accession:
GSE99687
ID:
200099687
7.

Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility

(Submitter supplied) Infertility in men and women is a common and complex genetic trait with shared biological bases between the sexes. We performed a series of rare variant analyses across 73,185 women and men to identify genes that contribute to primary gonadal dysfunction and identified CSMD1 as a strong candidate in both sexes. CSMD1 is a complement regulatory protein on chromosome 8p23. In order to interpret and support our genetic findings, we performed detailed transcriptomic and protein-based experiments which found CSMD1 enriched at the germ-cell/somatic-cell interface in both male and female gonads. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
28 Samples
Download data: TXT
Series
Accession:
GSE136769
ID:
200136769
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