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Links from GEO DataSets

Items: 20

1.

Comprehensive analysis of PPARa-dependent regulation of hepatic lipid metabolism by expression profiling

(Submitter supplied) PPARalpha is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARalpha in hepatic lipid metabolism, many PPARalpha-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARalpha-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARalpha target genes, livers from several animal studies in which PPARalpha was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Expression profiling by array
4 related Platforms
47 Samples
Download data: CEL
Series
Accession:
GSE8316
ID:
200008316
2.

Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 5

(Submitter supplied) PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARα-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARα target genes, livers from several animal studies in which PPARα was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Mus musculus; Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL1355 GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE8302
ID:
200008302
3.

Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 4

(Submitter supplied) PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARα-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARα target genes, livers from several animal studies in which PPARα was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE8295
ID:
200008295
4.

Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 3

(Submitter supplied) PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARα-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARα target genes, livers from several animal studies in which PPARα was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
17 Samples
Download data: CEL
Series
Accession:
GSE8292
ID:
200008292
5.

Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 2

(Submitter supplied) PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARα-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARα target genes, livers from several animal studies in which PPARα was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
4 Samples
Download data: CEL
Series
Accession:
GSE8291
ID:
200008291
6.

Comprehensive analysis of PPARα-dependent regulation of hepatic lipid metabolism by expression profiling - 1

(Submitter supplied) PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an overview of PPARα-regulated genes relevant to lipid metabolism, and to probe for novel candidate PPARα target genes, livers from several animal studies in which PPARα was activated and/or disabled were analyzed by Affymetrix GeneChips. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
4 Samples
Download data: CEL
Series
Accession:
GSE8290
ID:
200008290
7.

Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human

(Submitter supplied) Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of target gene regulation. Primary hepatocytes from 6 human and 6 mouse donors were treated with PPARα agonist Wy14643 and gene expression profiling was performed using Affymetrix GeneChips followed by a systems biology analysis. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL1261 GPL570
48 Samples
Download data: CEL
Series
Accession:
GSE17254
ID:
200017254
8.

Comparative analysis of gene regulation by the transcription factor PPARα_human

(Submitter supplied) Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of target gene regulation. Primary hepatocytes from 6 human and 6 mouse donors were treated with PPARα agonist Wy14643 and gene expression profiling was performed using Affymetrix GeneChips followed by a systems biology analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE17251
ID:
200017251
9.

Comparative analysis of gene regulation by the transcription factor PPARα_mouse

(Submitter supplied) Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of target gene regulation. Primary hepatocytes from 6 human and 6 mouse donors were treated with PPARα agonist Wy14643 and gene expression profiling was performed using Affymetrix GeneChips followed by a systems biology analysis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE17250
ID:
200017250
10.

The impact of PPARα activation on whole genome gene expression in human precision-cut liver slices

(Submitter supplied) Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in liver and a key transcription factor involved in the adaptive response to fasting. However, much less is known about the role of PPARα in human liver. Here we set out to study the function of PPARα in human liver via analysis of whole genome gene regulation in human liver slices treated with the PPARα agonist Wy14643. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL11532
8 Samples
Download data: CEL
Series
Accession:
GSE71731
ID:
200071731
11.

Transcriptional profiling of PPARα-/- and CREB3L3-/- livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

(Submitter supplied) Peroxisome Proliferator-Activated receptor α (PPARα) and cAMP-Responsive Element Binding Protein 3-Like 3 (CREB3L3) are transcription factors involved in the regulation of lipid metabolism in the liver. The aim of the present study was to characterize the interrelationship between PPARα and CREB3L3 in regulating hepatic gene expression. Male wildtype, PPARα-/-, CREB3L3-/- and combined PPARα/CREB3L3-/- mice were subjected to a 16-hour fast or 4 days of ketogenic diet. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
30 Samples
Download data: CEL
Series
Accession:
GSE121096
ID:
200121096
12.

PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.

(Submitter supplied) Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown. We investigated the regulation of vanin-1, and total vanin activity, by PPARα in mice and humans. Furthermore, the function of vanin-1 in the development of hepatic steatosis in response to starvation was examined in Vnn1 deficient mice, and in rats treated with an inhibitor of vanin activity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4872
Platform:
GPL11533
16 Samples
Download data: CEL
Series
Accession:
GSE51712
ID:
200051712
13.
Full record GDS4872

Fasting effect on vanin-1 depleted liver

Analysis of liver from vanin-1 KOs fasted for 24 hrs. Vanin-1 is highly expressed in liver compared to other tissues. In the fasted state, liver switches to fatty acid oxidation and glucose production. Results provide insight into the role of vanin-1 in hepatic lipid metabolism during starvation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11533
Series:
GSE51712
16 Samples
Download data: CEL
DataSet
Accession:
GDS4872
ID:
4872
14.

Regulatory Role for PC-TP/StarD2 in the Metabolic Response to Peroxisome Proliferator Activated Receptor Alpha (PPARα)

(Submitter supplied) Phosphatidylcholine transfer protein (PC-TP, a.k.a StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose homeostasis. Microarray profiling of liver from fenofibrate fed wild type and Pctp-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE17666
ID:
200017666
15.

Nordihydroguaiaretic Acid Improves Metabolic Dysregulation and Aberrant Hepatic Lipid Metabolism in Mice by Both PPAR-alpha-Dependent and -Independent Pathways

(Submitter supplied) To test whether NDGA attenuate dyslipidemia and hepatic steatosis by enhancing fatty acid oxidation through activation of PPAR-α. Using wild type (WT, C57BL/6) fed with chow diet as control, WT mice were either fed with high-fat diet or high-fat diet with NDGA (2.5g/kg food); ob/ob mice were fed with either chow or chow with NDGA (2.5 g/kg food), and maintained on the respective diets for 16 weeks. The expression of lipid metabolism related genes in the liver of these mice were analyzed using Phalanx GPL6845 platform (Mouse OneArray V1). Together with other biochemical/physiological data, our results suggest that the beneficial actions of NDGA on dyslipidemia and hepatic steatosis in ob/ob mice are exerted primarily through enhanced fatty acid oxidation and energy utilization via the activation of PPAR- α receptor activity.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6845
5 Samples
Download data: GPR
Series
Accession:
GSE35075
ID:
200035075
16.

The whole genome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

(Submitter supplied) The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known about the effect of PPARα activation in human liver. The aim of the present study was to better characterize the impact of PPARα activation on gene regulation in human liver by combining transcriptomics with the use of hepatocyte humanized livers. To that end, chimeric mice containing hepatocyte humanized livers were given an oral dose of 300 mg/kg fenofibrate daily for 4 days. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platform:
GPL11532
6 Samples
Download data: CEL
Series
Accession:
GSE107041
ID:
200107041
17.

Global hepatic gene expression data from PPARa liver-specific KO and PPARa liver wild-type male mice fed ad libitum

(Submitter supplied) To identify genes whose expression is under the strict dependence of hepatocyte PPARa activity, we used a mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to their liver WT littermates (albumin-Cre-/- Pparaflox/flox or LWT) fed ad libitum or fasted for 24 hours.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
24 Samples
Download data: TXT
Series
Accession:
GSE96559
ID:
200096559
18.

Analysis of the Heat Shock Response in Mouse Liver Reveals Transcriptional Dependence on the Nuclear Receptor PPARα

(Submitter supplied) The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) regulates responses to chemical or physical stress in part by altering expression of genes involved in proteome maintenance. Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARα and the HS response mediated by HSF1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE14869
ID:
200014869
19.

Effect of a High Phosphorus Diet on Hepatic Gene Expressions in Rat

(Submitter supplied) A high phosphorus (HP) diet causes disorders of renal function, bone metabolism, and vascular function. We previously demonstrated that DNA microarray analysis is an appropriate method to comprehensively evaluate the effects of a HP diet on kidney dysfunction such as calcification, fibrillization, and inflammation. We reported that type IIb sodium-dependent phosphate transporter is significantly up-regulated in this context. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE71201
ID:
200071201
20.

Hepatic transcriptome in wild-type and LXR-deficient mice

(Submitter supplied) LXR is a transcription factor. Two isoforms exist in mice (alpha and beta). They are both expressed in the liver. We examined the role of LXR by obtaining gene expression profiles from the livers of wild-type and LXR-/- mice from the same genetic background.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
20 Samples
Download data: TXT
Series
Accession:
GSE38083
ID:
200038083
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