Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.

SNP array analysis of neuroblastoma tumors

(Submitter supplied) Chromosome 1p LOH was seen in one-third of cases. LOH events on chromosomes 11q and 1p were generally accompanied by copy number loss. The one exception was on chromosome 11p, where LOH in all 4 cases was accompanied by normal copy number or diploidy, implying uniparental disomy. Amplification of MYCN was also noted, and also, amplification of a second gene, ALK, in a single case. Keywords: SNP array analysis
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL1266 GPL2641
44 Samples
Download data: CEL, TXT
Series
Accession:
GSE8333
ID:
200008333
2.

SNP array analysis of neuroblastic tumor NB99

(Submitter supplied) The genetic aberrations of NB tumor NB99 were determined using the Affymetrix SNP chip 50K array (Hind III).
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL2004
1 Sample
Download data: CEL
Series
Accession:
GSE12461
ID:
200012461
3.

Expression profiling of neuroblastic tumors

(Submitter supplied) The expression profiles of 64 neuroblastic tumors (mainly neuroblastoma) were determined on Affymetrix chips HG U133 Plus 2.0.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
64 Samples
Download data: CEL
Series
Accession:
GSE12460
ID:
200012460
4.

SNP data from Neuroblastoma samples

(Submitter supplied) Neuroblastoma in advanced stages is among the most intractable pediatric cancers, even with the recent therapeutic advances. Neruroblastoma harbours a variety of genetic changes, including a high frequency of MYCN amplification, loss of heterozygosity in 1p36 and 11q, and gain of genetic material from 17q, all of which have been implicated in the pathogenesis of neuroblastoma. However, the scarcity of reliable molecular targets has hampered the development of effective therapeutic agents targeting neuroblastoma. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platforms:
GPL2005 GPL3718 GPL2004
262 Samples
Download data: CEL, CHP
Series
Accession:
GSE12494
ID:
200012494
5.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL570 GPL2004
53 Samples
Download data: CEL
Series
Accession:
GSE13141
ID:
200013141
6.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL2004
23 Samples
Download data: CEL
Series
Accession:
GSE13137
ID:
200013137
7.

Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data

(Submitter supplied) Gene expression analysis was performed on 30 Neuroblastomas to identify genes whose transcription is significantly altered by recurrent chromosomal alterations. Genomic copy number losses and gains had been delineated in the tumours using FISH and SNP arrays. We have identified genes significantly altered by 7 recurrent alterations: 1p, 3p, 4p, 10q and 11q loss, 2p and 17q gain, and genes co-amplified and over-expressed as a result of MYCN amplification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE13136
ID:
200013136
8.

Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide SNP array analysis

(Submitter supplied) Stromal contamination is one of the major confounding factors in the analysis of primary solid tumor samples by single nucleotide polymorphism (SNP) arrays. As we propose to employ genome-wide SNP microarray analysis as a diagnostic platform for neuroblastoma, the sensitivity, specificity, and accuracy of these studies must be optimized. In order to investigate the effects of stroma, we derived early passage cell lines from nine primary tumors and compared their genomic signature with that of the primary tumors by 100K SNP array analysis. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL2004 GPL2005
54 Samples
Download data: CEL
Series
Accession:
GSE14656
ID:
200014656
9.

Combined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer

(Submitter supplied) BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygosity (LOH). Currently, high throughput methods such as array comparative genomic hybridization (array CGH), single nucleotide polymorphism array (SNP array) and gene expression arrays are available to study genome-wide alterations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array; Genome variation profiling by SNP array; SNP genotyping by SNP array
Platforms:
GPL4012 GPL2641 GPL201
40 Samples
Download data: CEL, GPR
Series
Accession:
GSE8605
ID:
200008605
10.

Classification of neuroblastoma by integrating gene expression pattern with regional alterations in DNA copy number

(Submitter supplied) The specific genes that influence neuroblastoma biology and are targeted by genomic alterations remain largely unknown. We quantified mRNA expression in a highly annotated series of 101 prospectively collected diagnostic neuroblastoma primary tumors and the expression profiles were determined using Affymetrix U95Av2 arrays. Comparisons between the sample groups allow the identification of genes with localized expression patterns. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
102 Samples
Download data: CEL
Series
Accession:
GSE3960
ID:
200003960
11.

Expression profiling of murine neuroblastoma in transgenic mice

(Submitter supplied) Neuroblastoma is an embryonal tumor arising from the neural crest. It can be mimicked in mice by neural crest-specific overepxression of oncogenes such as MYCN or mutated ALK.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4621
Platform:
GPL1261
13 Samples
Download data: CEL
Series
Accession:
GSE32386
ID:
200032386
12.
Full record GDS4621

Mutated anaplastic lymphoma kinase-driven neuroblastoma model

Analysis of neuroblastomas (NB) induced by mutated anaplastic lymphoma kinase (ALKF1174L), MYCN, or both oncogenes. ALK is a gene normally expressed in the developing nervous system. Results provide insight into the role of mutated ALK in tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 genotype/variation, 2 tissue sets
Platform:
GPL1261
Series:
GSE32386
13 Samples
Download data: CEL
DataSet
Accession:
GDS4621
ID:
4621
13.

Chromosome copy number and LOH analysis of colorectal carcinoma specimens

(Submitter supplied) Structural changes of chromosomes play important roles in the carcinogenesis of colorectal carcinoma (CRC). Here, by using SNP-typing arrays, we have tried to screen for recurrent chromosome copy number changes and loss-of-heterozygosity in the genome of colorectal carcinoma. Genomic DNA was isolated from tumor and paired normal tissues of CRC (n=94), and was hybridized to Affymetrix Mapping 50K Xba 240 arrays. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL2005
188 Samples
Download data: CEL
Series
Accession:
GSE11417
ID:
200011417
14.

Transcriptional profiles of transgenic ALK^F1174L/MYCN vs. MYCN tumors

(Submitter supplied) The ALK^F1174L mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK^F1174L in the neural crest. Comapred to mice expressing ALK^F1174L or MYCN alone, combined expression of the two aberrations led to development of neuroblastoma with a shorter latency and higher penetrance. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
10 Samples
Download data: TXT
Series
Accession:
GSE35560
ID:
200035560
15.

Genome-wide analysis of melanoma cell lines using high-density single-nucleotide polymorphism arrays.

(Submitter supplied) Although a number of genes related to melanoma development have been identified through candidate gene screening approaches, few studies have attempted to conduct such analyses on a genome-wide scale. Here we use Illumina 317K whole-genome single-nucleotide polymorphism arrays to define a comprehensive allelotype of melanoma based on loss of heterozygosity (LOH) and copy number changes in a panel of 76 melanoma cell lines. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL5711
76 Samples
Download data
Series
Accession:
GSE9003
ID:
200009003
16.

Expression data from neuroblastoma of TH-MYCN/KI Alk mice

(Submitter supplied) Neuroblastoma is an embryonal neoplasm that remains of dramatic prognosis in its aggressive forms. Activating mutations of the ALK tyrosine kinase receptor have been identified in sporadic and familial cases of this cancer. We generated knock-in mice carrying the two most frequent Alk mutations observed in neuroblastoma patients. We used microarrays to detail the global programme of gene expression underlying the impact of ALK mutations on neuroblastoma formation in a MYCN amplified background.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16225
31 Samples
Download data: CEL
Series
Accession:
GSE46583
ID:
200046583
17.

SNP arrays in matched diagnosis/remission samples of normal karyotype-acute myeloid leukemia

(Submitter supplied) We analysed, by last-generation high-resolution SNP arrays, Normal Karyotype (NK)-AML patients at diagnosis (Dx) and remission (R) phases, in order to determine the number of tumor-associated copy number abnormalities (CNAs) and copy neutral-loss of heterozygosity (CN-LOH) regions per patient and to identify possible recurring genomic abnormalities. The number of tumor-associated CNAs was detemined after comparison of 11 matched Dx/R samples using stringent conditions able to reduce the number of false positive CNAs. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array
Platform:
GPL6801
30 Samples
Download data: CEL, CNCHP, TXT
Series
Accession:
GSE21780
ID:
200021780
18.

Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by SNP array
Platforms:
GPL570 GPL3720
42 Samples
Download data: CEL
Series
Accession:
GSE22840
ID:
200022840
19.

Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast: copy number analysis

(Submitter supplied) Introduction: A major challenge in the interpretation of genomic profiling data generated from breast cancer samples is the identification of driver genes as distinct from bystander genes which do not impact tumorigenesis. One way to assess the relative importance of alterations in the transcriptome profile is to combine complementary analyses that assess changes in the copy number alterations (CNAs). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array
Platform:
GPL3720
22 Samples
Download data: CEL
Series
Accession:
GSE22839
ID:
200022839
20.

Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast: expression analysis

(Submitter supplied) Introduction: A major challenge in the interpretation of genomic profiling data generated from breast cancer samples is the identification of driver genes as distinct from bystander genes which do not impact tumorigenesis. One way to assess the relative importance of alterations in the transcriptome profile is to combine complementary analyses that assess changes in the copy number alterations (CNAs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE22544
ID:
200022544
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_61afb55ba6904515552b02fc|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center