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Links from GEO DataSets

Items: 15

1.

Inhibitor Trials

(Submitter supplied) Objectives: To identify similarities and differences in gene expression data in the MEK/ERK and PI3K pathways and to determine how histone modification affects these same pathways. Goal: To identify and functionally characterize novel targets of these signaling pathways in the context of chondrocyte differentiation. Keywords: Teatment, signaling, one-colour array, signaling pathway comparison
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL
Series
Accession:
GSE8488
ID:
200008488
2.

Inhibitor trials in chondrocytes - MAS 5.0 normalization

(Submitter supplied) Objectives: To identify similarities and differences in gene expression data in the MEK/ERK and PI3K pathways and to determine how histone modification affects these same pathways. Goal: To identify and functionally characterize novel targets of these signaling pathways in the context of chondrocyte differentiation. Keywords: Treatment, signaling, one-colour array, signaling pathway comparison
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE15069
ID:
200015069
3.

Gene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia

(Submitter supplied) We set out to generate transcriptional maps of chondrocyte UPR gene networks in vivo using two mouse models (Schmid and Cog) of Schmid chondrodysplasia, in order to define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress during hypertrophy, thus providing insights into ER stress signaling and its impact on cartilage pathophysiology. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE30628
ID:
200030628
4.

Microarray of Dexamethasone-treated primary chondrocytes identifies downstream targets of glucocorticoid signalling

(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2802
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7683
ID:
200007683
5.
Full record GDS2802

Dexamethasone effect on fetal chondrocytes in vitro: time course

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL1261
Series:
GSE7683
12 Samples
Download data: CEL, CHP, EXP
6.

Expression data of articular and growth plate cartilage zones in 10-day-old rat proximal tibial epiphysis

(Submitter supplied) Articular and growth plate cartilage have comparable structures consisting of three distinct layers of chondrocytes, suggesting similar differentiation programs and therefore similar gene expression profiles. To address this hypothesis and to explore transcriptional changes that occur during the onset of articular and growth plate cartilage divergence, we used microdissection of 10-day-old rat proximal tibial epiphyses, microarray analysis, and bioinformatics to compare gene expression profiles in individual layers of articular and growth plate cartilage. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS5434
Platform:
GPL6247
12 Samples
Download data: CEL
Series
Accession:
GSE54216
ID:
200054216
7.

Spatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray

(Submitter supplied) We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and implicated novel pathways, such as ephrin and integrin signaling, for spatially associated articular chondrocyte differentiation and proliferation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5433
Platform:
GPL1261
14 Samples
Download data: CEL, CHP
Series
Accession:
GSE51994
ID:
200051994
8.
Full record GDS5434

Articular and growth plate cartilage zones: 10-day old normal proximal tibia

Analysis of superficial (SZ) and intermediate/deep (IDZ) zones microdissected from articular cartilage and resting (RZ) zone from growth plate cartilage of proximal tibial epiphyses of 10-day old rats. Results provide insight into molecular basis of articular and growth plate cartilage divergence.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 3 tissue sets
Platform:
GPL6247
Series:
GSE54216
12 Samples
Download data: CEL
9.
Full record GDS5433

Articular cartilage zones: 1-week old normal proximal tibia

Analysis of superficial (SZ), intermediate/deep (IDZ), and resting (RZ) zones microdissected from articular cartilage of the proximal tibiae of 1-week old mice. Results provide insight into the spatial regulation of gene expression in articular cartilage.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 tissue sets
Platform:
GPL1261
Series:
GSE51994
14 Samples
Download data: CEL, CHP
10.

Microarray analysis of perichondral and reserve growth plate zones

(Submitter supplied) In the growth plate, the reserve and perichondral zones have been hypothesized to have similar functions, but their exact functions are poorly understood. Our hypothesis was that significant differential gene expression exists between perichondral and reserve chondrocytes that may differentiate the respective functions of these two zones. Normal Sprague-Dawley rat growth plate chondrocytes from the perichondral zone (PC), reserve zone (RZ), proliferative zone (PZ), and hypertrophic zone (HZ) were isolated by laser microdissection and then subjected to microarray analysis. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE9537
ID:
200009537
11.

Transcriptional profiling of growth plate chondrocyte differentiation yields insight into endochondral ossification

(Submitter supplied) A variety of cell cultures models and in vivo approaches have been used to study gene expression during chondrocyte differentiation. The extent to which the in vitro models reflect bona fide gene regulation in the growth plate has not been quantified. In addition, studies that evaluate global gene expression changes among different growth plate zones are limited. To address these issues, we completed a microarray screen of three growth plate zones derived from manually segmented embryonic mouse tibiae. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7685
ID:
200007685
12.

Bovine Hypertrophic Growth Plate Chondrocytes vs. Reserve Zone Chondrocytes

(Submitter supplied) Growth plate chondrocytes were isolated from the distal metacarpus of young dairy cattle (all under 10 mo of age), the chondrocytes were released from the extracellular matrix by digestion with Collagenase P for 4 hours, and the various zones of the growth plate were separated by density centrifugation. The least-dense Hypertrophic Zone (HZ) cells were compared to the most-dense Reserve Zone (RZ) cells. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Dataset:
GDS3733
Platform:
GPL2112
12 Samples
Download data: CEL
Series
Accession:
GSE18738
ID:
200018738
13.
Full record GDS3733

Growth plate chondrocytes

Analysis of growth plate chondrocytes, representing reserve and hypertrophic zones (RZ and HZ, respectively), isolated from metacarpals of prepubertal males. RZ cells terminally differentiate into non-dividing HZ cells. Results provide insight into the molecular basis of chondrocyte development.
Organism:
Bos taurus
Type:
Expression profiling by array, transformed count, 2 cell type sets
Platform:
GPL2112
Series:
GSE18738
12 Samples
Download data: CEL
14.

Spatial and Temporal Regulation of Gene Expression in the Mammalian Growth Plate

(Submitter supplied) To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
35 Samples
Download data: CEL
Series
Accession:
GSE16981
ID:
200016981
15.

Comparative transcriptomic analysis of the proximal tibial growth plates of 14-day old Longshanks and wildtype mice

(Submitter supplied) This study was undertaken to uncover the molecular pathways that underlie differences among individuals in rates of longitudinal growth and mature length of the long bones in a rodent model. To do so, the transcriptomic profiles of the proximal epiphyses of 14-day old CD-1 wildtype mice and the Longshanks mice were compared. The Longshanks mouse was selectively bred for longer tibiae in relation to body mass (see Marchini et al 2014 – BMC Evol Biol 14:258). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15907
6 Samples
Download data: TSV
Series
Accession:
GSE189528
ID:
200189528
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