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Links from GEO DataSets

Items: 5

1.

Pioglitazone treatment of Lethal Yellow mice

(Submitter supplied) Goal of the experiment: To examine differential gene expression in the ovaries of heterozygous Lethal Yellow (C57BL/6J Ay/a) mice treated with vehicle or pioglitazone. Brief description of the experiment: The objective of this study was to use whole mouse genome DNA microarrays (Codelink) to examine gene expression the ovaries of heterozygous Lethal Yellow (C57BL/6J Ay/a) mice. Women with polycystic ovary syndrome (PCOS) treated with thiazolidinediones (TZD), such as pioglitazone, show reduced androgen levels and improved ovulatory function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2897
8 Samples
Download data
Series
Accession:
GSE8806
ID:
200008806
2.

Altered ovarian gene expression in the lethal yellow mouse

(Submitter supplied) Mice possessing the lethal yellow (LY) agouti mutation (C57BL/6J Ay/a) exhibit adult-onset obesity, altered metabolic regulation, and early reproductive senescence. The present study was designed to test the hypothesis that aging obese mice possess differences in expression of ovarian genes involved in reproductive function relative to age-matched lean mice. To synchronize ovarian state and exclude gonadotropin-mediated effects, 90- and 180-day old diestrous LY and lean black (C57BL/6J a/a) mice were suppressed with GnRH antagonist (Antide®) for five days, then injected with 5 IU equine chorionic gonadotropin (eCG). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2897
12 Samples
Download data
Series
Accession:
GSE14937
ID:
200014937
3.

Gene expression profiling in skeletal muscle of PCOS after pioglitazone therapy

(Submitter supplied) Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in the transcriptional profile of muscle favoring insulin sensitivity. Using Affymetrix microarrays, we examined the effect of pioglitazone (30 mg/day for 16 weeks) on gene expression in skeletal muscle of 10 obese women with PCOS metabolically characterized by a euglycemic-hyperinsulinemic clamp. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4132 GDS4133
Platform:
GPL570
43 Samples
Download data: CEL
Series
Accession:
GSE8157
ID:
200008157
4.
Full record GDS4133

Obese women with polycystic ovary syndrome and obese, healthy women: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) and obese, healthy women. Results provide insight into whether pioglitazone ameliorates preexisting abnormalities in PCOS patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE8157
23 Samples
Download data: CEL
5.
Full record GDS4132

PPAR-γ agonist pioglitazone effect on obese women with polycystic ovary syndrome: skeletal muscle

Analysis of skeletal muscle from obese women with polycystic ovary syndrome (PCOS) before and after thiazolidinedione (TZD) pioglitazone treatment. TZDs improve metabolic disturbances in PCOS patients. Results provide insight into the molecular mechanisms underlying the effect of TZD in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE8157
20 Samples
Download data: CEL
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