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Links from GEO DataSets

Items: 12

1.

CLL in Em-TCL1 mice provides a biologically relevant model to unravel and reverse immune deficiency in human cancer.

(Submitter supplied) Immune deficiency is common in cancer, but the biological basis for this and ways to reverse it remains elusive. Here we present a mouse model of B cell chronic lymphocytic leukemia (CLL) that recapitulates changes in the non-malignant circulating T cells seen in patients with this illness.1 To validate this model, we examined changes in T cell gene expression, protein expression and function in Em-TCL1 transgenic mice as they developed CLL 2,3 and demonstrate that development of CLL in these transgenic mice is associated with changes in impaired T cell function and in gene expression in CD4 and CD8 T cells similar to those observed in patients with this disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
56 Samples
Download data: CEL, TXT
Series
Accession:
GSE8836
ID:
200008836
2.

ROR1 Can Interact With TCL1 And Enhance Leukemogenesis in Eµ-TCL1 Transgenic Mice

(Submitter supplied) Transcriptome analysis of RNA samples from leukemia cells of ROR1xTCL1 and TCL1 transgenic mice Animals engrafted with ROR1xTCL1 leukemia-cells developed more aggressive disease than mice engrafted with TCL1 leukemia cells. Transcriptome analysis of RNA samples from leukemia ROR1xTCL1 transgenic mice revealed shared common gene expression signatures that were distinct from those of TCL1 leukemia-cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE51420
ID:
200051420
3.

Accelerated progression of chronic lymphocytic leukemia in Eμ-TCL1 mice expressing catalytically inactive RAG1

(Submitter supplied) B cell chronic lymphocytic leukemia (CLL) is often preceded by a benign monoclonal or oligoclonal CD5+ B cell lymphocytosis. We have generated transgenic mice expressing a catalytically inactive, dominant-negative recombination activating gene 1 (dnRAG1 mice) in the periphery. These animals develop an early-onset indolent CD5+ B cell lymphocytosis, caused in part by a defect in secondary V(D)J rearrangements initiated to alter autoreactive B cell receptor specificity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
18 Samples
Download data: CEL, TXT
Series
Accession:
GSE44940
ID:
200044940
4.

Gene expression profile of splenic CD19 cells from NTg, PTPROt Tg, TCL1 Tg and PTPROt/TCL1 double Tg mice

(Submitter supplied) TCL1 is an an oncogene and transgenic (Tg) mice expressing TCL1 specifically in B-cells are well-characterized models for chronic lymphocytic leukemia. On the contrary, PTPROt is a phosphatase with tumor suppressor characteristics in many cancers including leukemia. Our hypothesis was that transgenic expression of PTPROt in the B-cells of TCL1 Tg mice will alleviate disease phenotype and allow the study of the in vivo mechanism of action of PTPROt. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE60582
ID:
200060582
5.

Affymetrix Gene Expression array data for Tcl1 mouse model samples

(Submitter supplied) Tcl1 is known to be involved in survival, proliferation and differentiation of human lymphocytes and mouse embryonic stem cells. Loss of Tcl1 gene in the KO mouse model affects skin integrity inducing alopecia and ulcerations. The study used epidermal keratinocytes from wild type (WT), Tcl1 knock down (KO) and K14-driven TCL1 transgenic (TGKO) mouse models to investigate the role of Tcl1 gene in the skin homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE118345
ID:
200118345
6.

Eμ-TCL1xMyc Mice as a Therapeutic Model of Accelerated B-cell Malignancy

(Submitter supplied) Richter’s syndrome (RS) is an aggressive B-cell lymphoma arising from chronic lymphocytic leukemia (CLL). RS patients are generally unresponsive both to conventional and B-cell receptor-targeted agents such as ibrutinib. Mouse models that mimic the biology and therapeutic response of RS are lacking, which hampers the development of alternative treatment strategies urgently needed to improve the dismal outcome of RS patients. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
9 Samples
Download data: TSV
Series
Accession:
GSE129515
ID:
200129515
7.

Lenaliddomide + IL21 in CLL

(Submitter supplied) These data show distinct interactions between these two drugs on CLL cells in vitro with an ex vivo treatment
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE79660
ID:
200079660
8.

CD3+ T-cells of B-cell chronic lymphocytic leukemia

(Submitter supplied) Analysis of T-cells isolated from CD3+ T-cells of patients with B-cell chronic lymphocytic leukemia (B-CLL). In contrast to other types of cancers, the non-malignant T-cell compartment of B CLL patients is expanded. Results provide insights into the role of T-cells in B-CLL.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
33 Samples
Download data: CEL
Series
Accession:
GSE19147
ID:
200019147
9.

Autoantigen promotes progression to aggressive TCL1 leukemia

(Submitter supplied) Activated BCR signaling in Murine CLL leukemia cells responsive to autoantigen phosphatidylcholine
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE45481
ID:
200045481
10.

Characterisation of gene expression changes in T cells from patients presenting with AML compared with healthy T cells

(Submitter supplied) Work previously published by our group has demonstrated that T cells from patients with chronic lymphocytic leukaemia (CLL) show differentially regulated genes compared with healthy T cells. This study was initiated to examine if these gene expression changes were unique to CLL T cells or common to an alternative leukaemia, acute myeloid leukaemia (AML). Keywords: Comparison of immune cells in health and disease
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
41 Samples
Download data: CEL, CHP
Series
Accession:
GSE14924
ID:
200014924
11.

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.

(Submitter supplied) To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic leukemia (CLL) with those from age-matched healthy donors. Although the cells analyzed were not part of the malignant clone, analysis revealed differentially expressed genes, mainly involved in cell differentiation in CD4 cells and defects in cytoskeleton formation, vesicle trafficking, and cytotoxicity in CD8 cells of the CLL patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
66 Samples
Download data: CEL, TXT
Series
Accession:
GSE8835
ID:
200008835
12.

MSCs in co-culture with CLL cells acquire a CAF-like phenotype.

(Submitter supplied) Human primary mesenchymal stromal cells (MSCs) were either left untreated, treated with 3 µg/ml/day GRN, or co-cultured with CD19-sorted CLL cells of two different patients for 5 days. Gene expression of the MSCs was quantified using an Illumina HumanHT-12 v4 Expression BeadChip. Thereby, genes assigned to 454 Illumina probes were identified to be significantly altered by CLL co-culture compared to control MSCs cultured alone (analysed dataset provided). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE129108
ID:
200129108
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