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Links from GEO DataSets

Items: 20

1.

Molecular correlates of sleep deprivation in the brain of three inbred mouse strains in an around-the-clock experiment

(Submitter supplied) These studies adress differential changes in gene expression between sleep deprived and control mice. We profiled gene expression at four time points across the 24H Light/Dark cycle to take into account circadian influences and used three different inbred strains to understand the influence of genetic background. Keywords: brain, circadian, genetic background, sleep deprivation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
71 Samples
Download data: CEL
Series
Accession:
GSE9442
ID:
200009442
2.

Sleep deprivation and the brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
131 Samples
Download data: CEL
Series
Accession:
GSE9444
ID:
200009444
3.

Gene expression in brain Homer1a-expressing cells after sleep deprivation

(Submitter supplied) To gain insight into the molecular changes of sleep need, this study addresses gene expression changes in a subpopulation of neurons selectively activated by sleep deprivation. Whole brain expression analyses after 6h sleep deprivation clearly indicate that Homer1a is the best index of sleep need, consistently in all mouse strains analyzed. Transgenic mice expressing a FLAG-tagged poly(A)-binding protein (PABP) under the control of Homer1a promoter were generated. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE9443
ID:
200009443
4.

The effect of sleep deprivation on gene expression in the brain and the liver of three inbred mouse strains

(Submitter supplied) These studies adress differential changes in gene expression between 6h sleep deprived and control mice in the brain and the liver. We profiled gene expression in three different inbred strains to understand the influence of genetic background. Keywords: brain, genetic background, sleep deprivation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
36 Samples
Download data: CEL
Series
Accession:
GSE9441
ID:
200009441
5.

Transcriptional Responses to Sleep in Peripheral Tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
158 Samples
Download data: CEL
Series
Accession:
GSE42362
ID:
200042362
6.

Transcriptional Responses to Sleep in Peripheral Tissues (Lung)

(Submitter supplied) Molecular profiles in sleep and sleep deprivation in peripheral tissues using microarrays
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
78 Samples
Download data: CEL
Series
Accession:
GSE42324
ID:
200042324
7.

Transcriptional Responses to Sleep in Peripheral Tissues (Heart)

(Submitter supplied) Molecular profiles in sleep and sleep deprivation in peripheral tissues using microarrays
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
80 Samples
Download data: CEL
Series
Accession:
GSE42323
ID:
200042323
8.

Effect of Sleep Deprivation on the Whole Brain of Drosophila

(Submitter supplied) To gain insight into the dynamic molecular processes that are altered during prolonged wakefulness and during sleep. We performed an RNA expression profiling study examining temporal changes in the brain of Drosophila in relationship to the duration of prior sleep or wakefulness. Our experimental design allowed us to determine whether genes identified as differentially regulated between sleep and wakefulness were up- or down-regulated in these states. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Dataset:
GDS1686
Platform:
GPL72
30 Samples
Download data: CEL, EXP
Series
Accession:
GSE4174
ID:
200004174
9.
Full record GDS1686

Sleep deprivation effect on the brain: time course

Analysis of brain of Canton-S females deprived of sleep by perturbations during their normal sleep period. Perturbation effect also assessed during their active period to control for its effect during sleep deprivation. Results suggest processes altered during prolonged wakefulness and during sleep.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, transformed count, 6 protocol, 4 time sets
Platform:
GPL72
Series:
GSE4174
30 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1686
ID:
1686
10.

Sleep-wake driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex

(Submitter supplied) We monitored gene expression and chromatin accessibility in the cerebral cortex of 10-12 week-old male C57BL/6J mice for 24 hours before and until 48 hours after the end of a single total sleep deprivation (SD) episode. The aim was to characterise the response to SD and recovery thereafter.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
123 Samples
Download data: GTF, TXT
Series
Accession:
GSE140345
ID:
200140345
11.

Gene expression linked to sleep homeostasis in murine cortex

(Submitter supplied) Why we sleep is still one of the most perplexing mysteries in biology. Strong evidence, however, indicates that sleep is necessary for normal brain function and that the need to sleep is a tightly regulated process. Surprisingly molecular mechanisms that determine the need to sleep are incompletely described. Moreover, very little is known about transcriptional changes that specifically accompany the accumulation and discharge of sleep need. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
65 Samples
Download data: CEL
Series
Accession:
GSE78215
ID:
200078215
12.

The peripheral genome-wide gene expression profiles in humans after prolonged wakefulness and sleep recovery

(Submitter supplied) Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is associated with changes in behavioral, neurochemical, cellular, and metabolic function as well as impaired immune response. We evaluated the gene expression profiles of healthy male volunteers who underwent 60 hours of prolonged wakefulness (PW) followed by 12 hours of sleep recovery (SR) using high-resolution microarrays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
27 Samples
Download data: CEL
Series
Accession:
GSE37667
ID:
200037667
13.

Diurnally regulated gene expression in the prefrontal cortex of C57Bl/6J mice at Zeitgeber Time (ZT) 3, 9, 15, and 21.

(Submitter supplied) Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3080
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE9471
ID:
200009471
14.
Full record GDS3080

Prefrontal cortex during a 24 hour (12 hour light:12 hour dark) cycle

Analysis of prefrontal cortices from C57BL/6J animals at 4 Zeitgeber time (ZT) points, 3 and 9 hrs after lights on (ZT3 and ZT9) and 3 and 9 hs after lights off (ZT15 and ZT21). The prefrontal cortex is important in regulating sleep and mood. Results provide insight into genes with diurnal rhythms.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 time sets
Platform:
GPL1261
Series:
GSE9471
12 Samples
Download data: CEL
15.

β-catenin regulates FSHβ induction by GnRH: next generation RNA-Sequencing identifies Brms1L as a mediator of beta-catenin regulation of FSHβ gene expression

(Submitter supplied) The regulation of gonadotropin synthesis by GnRH (Gonadotropin-releasing hormone) plays an essential role in the neuroendocrine control of reproduction. The known signaling mechanisms involved in gonadotropin synthesis have been expanding. For example, involvement of β-catenin in LHβ induction by GnRH has been discovered. We examined the role of β-catenin in FSHβ gene expression in LβT2 gonadotrope cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
24 Samples
Download data: TXT
Series
Accession:
GSE42120
ID:
200042120
16.

TRAP-Seq uncovers post-transcriptional gene regulation after acute sleep deprivation

(Submitter supplied) To identify the effects of sleep deprivation on the translatome, we took advantage of the RiboTag mouse line with an HA labeled ribosomal protein to express labeled Rpl22 in CaMKIIa neurons to selectively isolate and then sequence mRNA transcripts associated with ribosomes
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
11 Samples
Download data: TXT
Series
Accession:
GSE156925
ID:
200156925
17.

The Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging

(Submitter supplied) Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate potential molecular relationships between SD and aging in brain tissue. Here, we tested the hypothesis that young rats exposed to 24 or 72 hour SD would respond with stress and aging-like shifts in brain hippocampal CA1 gene expression. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
69 Samples
Download data: CEL
Series
Accession:
GSE34424
ID:
200034424
18.

Multi-brain-region transcriptional organization linking sleep and affective functions

(Submitter supplied) Sleep and affective behaviors are highly interrelated phenotypes, commonly altered in a variety of neuropsychiatric diseases, including major depressive disorder (MDD). To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J x 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions, including the frontal cortex, hippocampus, thalamus, and hypothalamus. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
383 Samples
Download data: CEL, XLSX
Series
Accession:
GSE109112
ID:
200109112
19.

Fxr1 regulates sleep and synaptic homeostasis

(Submitter supplied) Comparison of ribosome associated RNA between Ctrl vs EW (or SD) and EW (or SD) vs EWFxr1 (or SDFxr1)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: TSV
Series
Accession:
GSE139576
ID:
200139576
20.

Age Attenuates the Transcriptional Changes that Occur with Sleep in the Medial Prefrontal Cortex

(Submitter supplied) Sleep abnormalities are common with aging. Studies show that sleep plays important roles in brain functions, and loss of sleep is associated with increased risks for neurological diseases. In this study, we used next generation RNA-sequencing to explore effects of age on transcriptome changes between sleep and sleep deprivation in medial prefrontal cortex. Old mice showed a 30% reduction in the number of genes significantly altered between sleep/wake, and, in general, had smaller magnitudes of changes in differentially expressed genes compared to young. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
108 Samples
Download data: TXT
Series
Accession:
GSE128770
ID:
200128770
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