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Links from GEO DataSets

Items: 20

1.

Microarray analysis of perichondral and reserve growth plate zones

(Submitter supplied) In the growth plate, the reserve and perichondral zones have been hypothesized to have similar functions, but their exact functions are poorly understood. Our hypothesis was that significant differential gene expression exists between perichondral and reserve chondrocytes that may differentiate the respective functions of these two zones. Normal Sprague-Dawley rat growth plate chondrocytes from the perichondral zone (PC), reserve zone (RZ), proliferative zone (PZ), and hypertrophic zone (HZ) were isolated by laser microdissection and then subjected to microarray analysis. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE9537
ID:
200009537
2.

Gene expression analysis of ER-stressed growth plate chondrocytes in two mouse models of Schmid chondrodysplasia

(Submitter supplied) We set out to generate transcriptional maps of chondrocyte UPR gene networks in vivo using two mouse models (Schmid and Cog) of Schmid chondrodysplasia, in order to define the consequences of UPR activation for the adaptation, differentiation, and survival of chondrocytes experiencing ER stress during hypertrophy, thus providing insights into ER stress signaling and its impact on cartilage pathophysiology. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE30628
ID:
200030628
3.

Spatial and Temporal Regulation of Gene Expression in the Mammalian Growth Plate

(Submitter supplied) To explore the mechanisms responsible for spatial and temporal regulation of the growth plate, we microdissected postnatal rat growth plates into their constituent zones and then used microarray analysis to characterize the changes in gene expression that occur as chondrocytes undergo spatially-associated differentiation and temporally-associated senescence.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
35 Samples
Download data: CEL
Series
Accession:
GSE16981
ID:
200016981
4.

Expression data of articular and growth plate cartilage zones in 10-day-old rat proximal tibial epiphysis

(Submitter supplied) Articular and growth plate cartilage have comparable structures consisting of three distinct layers of chondrocytes, suggesting similar differentiation programs and therefore similar gene expression profiles. To address this hypothesis and to explore transcriptional changes that occur during the onset of articular and growth plate cartilage divergence, we used microdissection of 10-day-old rat proximal tibial epiphyses, microarray analysis, and bioinformatics to compare gene expression profiles in individual layers of articular and growth plate cartilage. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS5434
Platform:
GPL6247
12 Samples
Download data: CEL
Series
Accession:
GSE54216
ID:
200054216
5.

Spatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray

(Submitter supplied) We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and implicated novel pathways, such as ephrin and integrin signaling, for spatially associated articular chondrocyte differentiation and proliferation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5433
Platform:
GPL1261
14 Samples
Download data: CEL, CHP
Series
Accession:
GSE51994
ID:
200051994
6.
Full record GDS5434

Articular and growth plate cartilage zones: 10-day old normal proximal tibia

Analysis of superficial (SZ) and intermediate/deep (IDZ) zones microdissected from articular cartilage and resting (RZ) zone from growth plate cartilage of proximal tibial epiphyses of 10-day old rats. Results provide insight into molecular basis of articular and growth plate cartilage divergence.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 3 tissue sets
Platform:
GPL6247
Series:
GSE54216
12 Samples
Download data: CEL
7.
Full record GDS5433

Articular cartilage zones: 1-week old normal proximal tibia

Analysis of superficial (SZ), intermediate/deep (IDZ), and resting (RZ) zones microdissected from articular cartilage of the proximal tibiae of 1-week old mice. Results provide insight into the spatial regulation of gene expression in articular cartilage.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 tissue sets
Platform:
GPL1261
Series:
GSE51994
14 Samples
Download data: CEL, CHP
8.

Chondrocyte Gene Expression in Proliferative and Hypertrophic Chondrocytes of Chick

(Submitter supplied) Longitudinal bone growth depends upon the execution of an intricate series of cellular activities by epiphyseal growth plate chondrocytes. In order to better understand these coordinated events, microarray analysis was used to compare gene expression in chondrocytes isolated from the proliferative and hypertrophic zones of the avian growth plate. In this experiment we compared pooled samples of proliferative and hypertrophic chondrocytes isolated from the chick growth plate. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL3213
8 Samples
Download data: CEL
Series
Accession:
GSE18568
ID:
200018568
9.

Inhibitor trials in chondrocytes - MAS 5.0 normalization

(Submitter supplied) Objectives: To identify similarities and differences in gene expression data in the MEK/ERK and PI3K pathways and to determine how histone modification affects these same pathways. Goal: To identify and functionally characterize novel targets of these signaling pathways in the context of chondrocyte differentiation. Keywords: Treatment, signaling, one-colour array, signaling pathway comparison
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE15069
ID:
200015069
10.

Inhibitor Trials

(Submitter supplied) Objectives: To identify similarities and differences in gene expression data in the MEK/ERK and PI3K pathways and to determine how histone modification affects these same pathways. Goal: To identify and functionally characterize novel targets of these signaling pathways in the context of chondrocyte differentiation. Keywords: Teatment, signaling, one-colour array, signaling pathway comparison
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
15 Samples
Download data: CEL
Series
Accession:
GSE8488
ID:
200008488
11.

Bovine Hypertrophic Growth Plate Chondrocytes vs. Reserve Zone Chondrocytes

(Submitter supplied) Growth plate chondrocytes were isolated from the distal metacarpus of young dairy cattle (all under 10 mo of age), the chondrocytes were released from the extracellular matrix by digestion with Collagenase P for 4 hours, and the various zones of the growth plate were separated by density centrifugation. The least-dense Hypertrophic Zone (HZ) cells were compared to the most-dense Reserve Zone (RZ) cells. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Dataset:
GDS3733
Platform:
GPL2112
12 Samples
Download data: CEL
Series
Accession:
GSE18738
ID:
200018738
12.
Full record GDS3733

Growth plate chondrocytes

Analysis of growth plate chondrocytes, representing reserve and hypertrophic zones (RZ and HZ, respectively), isolated from metacarpals of prepubertal males. RZ cells terminally differentiate into non-dividing HZ cells. Results provide insight into the molecular basis of chondrocyte development.
Organism:
Bos taurus
Type:
Expression profiling by array, transformed count, 2 cell type sets
Platform:
GPL2112
Series:
GSE18738
12 Samples
Download data: CEL
13.

TNF-a-induced MEK/ERK-dependent regulation of Cartilage Matrix Genes

(Submitter supplied) TNF-a is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNF-a activates MEK/ERK in chondrocytes; however the overall functional relevance of MEK/ERK to TNF-a-regulated gene expression in chondrocytes is unknown. Chondrocytes were treated with TNF-a with or without the MEK1/2 inhibitor U0126 for 24 h. Microarray analysis was used to identify genes regulated by TNF-a in a MEK1/2-dependent fashion. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE14402
ID:
200014402
14.

KB001b:Gene expression profiling of the growth plate of large and small breed dogs provides new insights in endochondral bone formation

(Submitter supplied) The regeneration of bone in large bone defects remains a challenge in orthopaedics. It may be possible that the difference in the adult height of mammals, and hence in endochondral bone formation, can serve to identify targets for bone regeneration. In line with this hypothesis, the intra-species disparity in adult height of Great Danes and Miniature Poodles was investigated at a transcriptional level. more...
Organism:
Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL15184
22 Samples
Download data: TXT
Series
Accession:
GSE53277
ID:
200053277
15.

Microarray of Dexamethasone-treated primary chondrocytes identifies downstream targets of glucocorticoid signalling

(Submitter supplied) Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regulation of chondrogenesis and osteoblast differentiation, as well as maintaining homeostasis in cartilage and bone. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2802
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7683
ID:
200007683
16.
Full record GDS2802

Dexamethasone effect on fetal chondrocytes in vitro: time course

Analysis of primary cultured fetal chondrocytes treated with pharmacological doses of dexamethasone (DEX) for 6 and 24 hours. DEX is a synthetic glucorticoid (GC) receptor agonist. Results provide insight into the effects of pharmacological GC on chondrocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL1261
Series:
GSE7683
12 Samples
Download data: CEL, CHP, EXP
17.

Expression data from mandibular condylar cartilage of rats

(Submitter supplied) Mandibular condylar cartilage (MCC) has many distinctive features reviewed in the literature, hence it would be expected that the genetic regulation of the biological process in the MCC to be different from those of other articular hyaline cartilages and epiphyseal growth cartilages. In addition, The MCC is a multi-zonal fibrocartilage containing different types of cells, which are well characterized histomorphologically, but the factors governing their morphological transition across the zones are not fully understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
5 Samples
Download data: CEL
Series
Accession:
GSE162823
ID:
200162823
18.

Angus PRKG2 R678X homozygous (dwarf) cattle vs unaffected growth plate cartilage

(Submitter supplied) Kinase activity of cGMP-dependant, type II, protein kinase (PRKG2) is required for the proliferative to hypertrophic growth transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function in rodent and bovine models results in dwarfism. We compared growth plate cartilage gene expression profiles of PRKG2R678X/R678X, dwarf and PRKG2R678X/+, unaffected Angus cattle using microarray technology to discover pathways regulated by PRKG2. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL8813
12 Samples
Download data: TXT
Series
Accession:
GSE31627
ID:
200031627
19.

Differential Gene Expression Associated With Postnatal Articular Cartilage Maturation

(Submitter supplied) Chondrocyte gene expression was analyzed to study mechanisms involved in the structural and functional adaptation of articular cartilage during postnatal maturation. Transcriptional profiling was used to compare articular chondrocytes between four neonatal and four adult horses. Expressional differences featured matrix proteins and matrix-modifying enzymes reflecting the transition from cartilage growth to cartilage homeostasis. more...
Organism:
Equus caballus
Type:
Expression profiling by array
Platform:
GPL6423
4 Samples
Download data: GPR
Series
Accession:
GSE10303
ID:
200010303
20.

Transcriptional profiling of growth plate chondrocyte differentiation yields insight into endochondral ossification

(Submitter supplied) A variety of cell cultures models and in vivo approaches have been used to study gene expression during chondrocyte differentiation. The extent to which the in vitro models reflect bona fide gene regulation in the growth plate has not been quantified. In addition, studies that evaluate global gene expression changes among different growth plate zones are limited. To address these issues, we completed a microarray screen of three growth plate zones derived from manually segmented embryonic mouse tibiae. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7685
ID:
200007685
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