Similar studies for GEO DataSets (Select 200009620) - GEO DataSets

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Items: 20

Select item 2000096201.

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6126 GPL6145
16 Samples

Download data: GPR, TIFF

Series

Accession:: GSE9620

ID:: 200009620

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000096192.

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NeuroDev microarray

(Submitter supplied) Branchiomotor neurons are an important class of cranial motor neurons that innervate the branchial-arch-derived muscles of the face, jaw and neck. They arise in the ventralmost progenitor domain of the rhombencephalon characterized by expression of the homeodomain transcription factors Nkx2.2 and Phox2b. Phox2b in particular plays a key role in the specification of branchiomotor neurons. In its absence, generic neuronal differentiation is defective in the progenitor domain, and no branchiomotor neurons are produced. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6145
8 Samples

Download data: GPR, TIFF

Series

Accession:: GSE9619

ID:: 200009619

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Select item 2000096033.

Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors on NIA 15k microarray

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6126
8 Samples

Download data: GPR, TIFF

Series

Accession:: GSE9603

ID:: 200009603

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Select item 2000558414.

Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL11002 GPL9185
13 Samples

Download data: BEDGRAPH

Series

Accession:: GSE55841

ID:: 200055841

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Select item 2000558405.

Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord [ChIP-Seq]

(Submitter supplied) The proper balance of excitatory and inhibitory neurons is crucial to normal processing of somatosensory information in the dorsal spinal cord. Two neural basic helix-loop-helix transcription factors, Ascl1 and Ptf1a, are essential for generating the correct number and sub-type of neurons in multiple regions of the nervous system. In the dorsal spinal cord, Ascl1 and Ptf1a have contrasting functions in specifying inhibitory versus excitatory neurons. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9185 GPL11002
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE55840

ID:: 200055840

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000558316.

Transcription Factor Network Specifying Inhibitory versus Excitatory Neurons in the Dorsal Spinal Cord [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL11002
7 Samples

Download data: TXT

Series

Accession:: GSE55831

ID:: 200055831

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000909387.

Repression by PRDM13 is critical for generating precise neuronal identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: BW

Series

Accession:: GSE90938

ID:: 200090938

PubMed Full text in PMC Similar studies

Select item 2000909378.

Repression by PRDM13 is critical for generating precise neuronal identity (RNA-Seq)

(Submitter supplied) The mechanisms that activate some genes while silencing others are critical to ensure precision in lineage specification as multipotent progenitors become restricted in cell fate. During neurodevelopment, these mechanisms are required to generate the wide variety of neuronal subtypes found in the nervous system. Here we report interactions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional repressor PRDM13 that are critical for these processes during specification of dorsal spinal cord neurons. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE90937

ID:: 200090937

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000909369.

Repression by PRDM13 is critical for generating precise neuronal identity (ChIP-Seq)

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BW

Series

Accession:: GSE90936

ID:: 200090936

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003551010.

Isl1-Lhx3 fusion specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs

(Submitter supplied) Combinatorial transcription codes generate the myriad of cell types during development, and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM-complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we report that Isl1-Lhx3, a LIMcomplex-mimicking fusion, induces a signature of MN transcriptome and concomitantly suppresses interneuron differentiation programs, thereby serving as a potent and specific inducer of MNs in stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE35510

ID:: 200035510

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011428511.

Next Generation Sequencing Facilitates Quantitative Analysis of ES, pMN, MN, and IN Transcriptomes

(Submitter supplied) In this experiment, we sought to identification the stage specific lncRNAs from the transcriptome of WT cells during differentiation of ESCs into cervical motor neurons

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL16417
9 Samples

Download data: XLSX

Series

Accession:: GSE114285

ID:: 200114285

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011428312.

Genome-wide maps of H3K27me3 in chromatin state in embryonic stem cells differentiated motor neurons

(Submitter supplied) In this experiment, we sought to identify how the distribution of H3K27me3 upon Meg3 KD

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE114283

ID:: 200114283

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011422813.

Transcriptome analysis of Meg3 KD and IG-DMR maternal deletion in ESC, pMN, and MN

(Submitter supplied) Analysis of gene expression at three time-points upon Meg3 KD and IG-DMR maternal deletion during motor neuron differentiation

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
8 Samples

Download data: TXT

Series

Accession:: GSE114228

ID:: 200114228

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Select item 20002308914.

Molecular Determinants of Dorsal Spinal Cord Interneurons Specified by Atoh1 (Math1)

(Submitter supplied) Neural basic helix-loop-helix (bHLH) transcription factors are important for the differentiation and cell type specification of neurons. They are thought to share direct downstream targets in their common role as neuronal differentiation factors, but have distinct targets with respect to their cell type specific roles. Little is known about distinct cell-type specific bHLH targets as previous work did not distinguish these from common targets. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE23089

ID:: 200023089

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Select item 20006546215.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions and overexpression in neural progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL19057 GPL9250
28 Samples

Download data: BED

Series

Accession:: GSE65462

ID:: 200065462

PubMed Full text in PMC Similar studies

Select item 20006545716.

mRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
15 Samples

Download data: XLSX

Series

Accession:: GSE65457

ID:: 200065457

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006167317.

Nkx2.2, Nkx6.1, Olig2, and Gli3 genomic binding regions in neural progenitors [ChIP-Seq]

(Submitter supplied) Nkx2.2, Nkx6.1, and Olig2 are transcriptional repressors regulating somatic motor neuron and interneuron subtypes in neural progenitors. The purpose of this study was to identify their target genes and to elucidate their gene regulatory mechanisms, including their relationship to Sonic Hedgehog/Gli pathway.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL13112 GPL9250
13 Samples

Download data: BED, TXT

Series

Accession:: GSE61673

ID:: 200061673

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003145618.

Transcriptional mechanisms controlling direct motor neuron programming

(Submitter supplied) Transcriptional programming of cell identity promises to open up new frontiers in regenerative medicine by enabling the efficient production of clinically relevant cell types. We examine if such cellular programming is accomplished by transcription factors that each have an independent and additive effect on cellular identity, or if programming factors synergize to produce an effect that is not independently obtainable. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6246 GPL11002 GPL9250
26 Samples

Download data: BAM, BED, BW, CEL, TXT, WIG

Series

Accession:: GSE31456

ID:: 200031456

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20004179519.

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

(Submitter supplied) Human pluripotent stem cells are a promising source of diverse cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of existing protocols for in vitro differentiation and by the molecular heterogeneity of the populations generated. more...