Similar studies for GEO DataSets (Select 200009756) - GEO DataSets

Select item 2000097561.

(Submitter supplied) The integration of positive and negative intra- and extra-cellular signals dictates whether a cell will proliferate or differentiate. While it is intuitive to speculate that nutrients availability may influence this alternative, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. In this study, we will investigate how nutrients (glucose) affect skeletal myogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL340 GPL339
24 Samples

Download data: CEL

Series

Accession:: GSE9756

ID:: 200009756

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000135772.

SIRT1-Dependent Gene Regulation Through Promoter-Directed Recruitment of a Nuclear NAD+ Synthase

(Submitter supplied) In mammals, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT-1) constitute a nuclear NAD+ salvage pathway, regulating cellular functions of the NAD+-dependent deacetylase SIRT1. However, little is known about the molecular mechanisms by which NAD+ biosynthesis controls gene transcription in the nucleus. In this study, we show that stable knockdown of NAMPT or NMNAT-1 in MCF-7 breast cancer cells significantly reduced total cellular NAD+ levels. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL571 GPL570
24 Samples

Download data: CEL

Series

Accession:: GSE13577

ID:: 200013577

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000134593.

Expression analysis upon SIRT1 knockdown in MCF-7 cells

(Submitter supplied) SIRT1 is a nuclear NAD+-dependent protein deacetylase. Expression microarray analysis was used to study the effect of SIRT1 knockdown on gene expression in MCF-7 breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
6 Samples

Download data: CEL

Series

Accession:: GSE13459

ID:: 200013459

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000134584.

Expression analysis upon NMNAT1 knockdown in MCF-7 cells

(Submitter supplied) NMNAT1 is a nuclear enzyme in the mammalian NAD+ salvage pathway. Expression microarray analysis was used to study the effect of NMNAT1 knockdown on gene expression in MCF-7 breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL571
12 Samples

Download data: CEL

Series

Accession:: GSE13458

ID:: 200013458

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000134495.

Expression analysis upon NAMPT knockdown in MCF-7 cells

(Submitter supplied) NAMPT is an enzyme in the mammalian NAD+ salvage pathway. Expression microarray analysis was used to study the effect of NAMPT knockdown on gene expression in MCF-7 breast cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
6 Samples

Download data: CEL

Series

Accession:: GSE13449

ID:: 200013449

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000129716.

MCF-7 Luciferase, PARP-1, PARG, SIRT1, and macroH2A Knockdown

(Submitter supplied) Affymetrix expression arrays were used to compare expression patterns upon knockdown of PARP-1, PARG, SIRT1, or macroH2A in comparison to Luciferase control.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
15 Samples

Download data: CEL

Series

Accession:: GSE12971

ID:: 200012971

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001845137.

Role of NAMPT in liver gene expression in diabetic mice

(Submitter supplied) We tested they hypothesis that hepatocyte NAMPT mediates transcriptomic changes in diabetic mice

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
8 Samples

Download data: TXT

Series

Accession:: GSE184513

ID:: 200184513

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001843958.

Role of hepatocyte NAMPT in fasting-induced liver gene expression

(Submitter supplied) We tested they hypothesis that hepatocyte NAMPT mediates transcriptomic changes induced by fasting

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: TXT

Series

Accession:: GSE184395

ID:: 200184395

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001843949.

Role of SIRT1 in NAMPT-induced liver gene expression

(Submitter supplied) We tested they hypothesis that hepatocyte SIRT1 mediates transcriptomic changes induced by hepatocyte-specific NAMPT overexpression

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
25 Samples

Download data: TXT

Series

Accession:: GSE184394

ID:: 200184394

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000406710.

AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

(Submitter supplied) Note: GSE4063 and GSE4065 are not directly comparable. This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL339
24 Samples

Download data: CEL, EXP

Series

Accession:: GSE4067

ID:: 200004067

Select item 20000406511.

Gene expression in skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates.

(Submitter supplied) Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 mutant (R225Q) transgenic mice and corresponding wild type littermates. Keywords: Genetic modification

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1939
Platform:: GPL339
12 Samples

Download data: CEL, EXP

Series

Accession:: GSE4065

ID:: 200004065

Select item 20000406312.

Gene expression in skeletal muscle in AMPK gamma3 knock-out mice and wild type littermates

(Submitter supplied) Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 knock-out mice and corresponding wild type littermates. Keywords: Genetic modification

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1938
Platform:: GPL339
12 Samples

Download data: CEL, EXP

Series

Accession:: GSE4063

ID:: 200004063

Select item 193913.

AMP-activated protein kinase gamma-3 R225Q mutation effect on skeletal muscle

Analysis of white portions of gastrocnemius muscles from AMP-activated protein kinase (AMPK) gamma-3 R225Q transgenic mutants. AMPK gamma-3 is important in glucose uptake, glycogen synthesis, and fat oxidation. Results compared to those from AMPK gamma-3 knockout mutant (GDS1938).

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE4065
12 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1939

ID:: 1939

Select item 193814.

AMP-activated protein kinase gamma-3 knockout effect on skeletal muscle

Analysis of white portions of gastrocnemius muscles from AMP-activated protein kinase (AMPK) gamma-3 knockout mutants. AMPK gamma-3 is important in glucose uptake, glycogen synthesis, and fat oxidation. Results compared to those from AMPK gamma-3 R225Q transgenic mutant (GDS1939).

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL339
Series:: GSE4063
12 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS1938

ID:: 1938

Select item 20003541415.

Molecular sequelae of Nampt Inhibition in Human Multiple Myeloma cell line

(Submitter supplied) Evaluation of specific coordinated pattern of transcriptional events consistent with anti-myeloma activity of FK866 (chemical Nampt inhibitor)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
3 Samples

Download data: CEL

Series

Accession:: GSE35414

ID:: 200035414

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013583116.

Exogenous pyruvate represses histone gene expression to inhibit cancer cell proliferation via the NAMPT-NAD + -SIRT1 pathway

(Submitter supplied) Pyruvate is a glycolytic metabolite used for energy production and macromolecule biosynthesis. However, little is known about its potential functions in tumorigenesis. Here,we report that exogenous pyruvate inhibits the proliferation of different types of cancer cells. This inhibitory effect of pyruvate on cell growth is attributed to its function as a signal molecule to repress histone gene expression, which leads to less compact chromatin structure and misregulation of genome-wide gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: XLS

Series

Accession:: GSE135831

ID:: 200135831

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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