GEO DataSets

(Submitter supplied) Analysis of changes of gene expression profiles in the left ventricle (LV) during the progression of heart failure (HF) in the canine tachypacing induced HF model. Gene expression profiling was performed on samples collected at different time points representing various stages of LV dysfunction, i.e. tachypaced for 3 days (Day-3), 1 week (Week-1), 2 weeks (Week-2), 3-4 weeks (End stage), and unpaced controls (Day-0). more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3979

45 Samples

Download data: CEL, CHP

(Submitter supplied) We have used chronic cardiac pacing in conscious dogs to study mechanism related to the development of dilated cardiomyopathy and the transition from compensated dysfunction (CD) to decompensated heart failure (HF). This occurs from the 3rd to 4th week of pacing with end-stage HF at 30?1 days. Keywords: disease state analysis

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Dataset:

GDS2424

Platform:

GPL3979

12 Samples

Download data: CEL

Analysis of hearts of animals subjected to chronic cardiac pacing for 3 or 4 weeks. The transition from compensated dysfunction to decompensated heart failure (HF) occurs between the third and fourth week of pacing. Results provide insight into the progression to decompensated HF.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array, count, 2 protocol, 3 time sets

Platform:

GPL3979

Series:

GSE5247

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL11202 GPL6885

37 Samples

Download data: TXT

(Submitter supplied) Wild type, female, C57BL/6 mice were subjected to sham (n=6) surgery, or TAC + MI to cause progressive LV remodeling (n=12). At 2wks post-TAC, one group of mice underwent de-banding (HF-DB, n=6), whereas in a second group of mice the band remained intact (HF; n = 6). LV remodeling was evaluated by 2D echocardiography at 14 days post-TAC+MI , and 4 wks post-debanding. At 6 wks the hearts were excised and analyzed for changes in gene expression using transcriptional profiling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT

(Submitter supplied) Wild type, female, C57BL/6 mice were subjected to sham (n=6) surgery, or TAC + MI to cause progressive LV remodeling (n=13). At 2wks post-TAC, one group of mice underwent de-banding (HF-DB, n=6), whereas in a second group of mice the band remained intact (HF_shDB; n = 7). LV remodeling was evaluated by 2D echocardiography at 14 days post-TAC+MI , and 2 wks post-debanding. At 4 wks the hearts were excised and analyzed for changes in gene expression using transcriptional profiling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11202

19 Samples

Download data: TXT

(Submitter supplied) Compelling evidence suggests that mitochondrial dysfunction contributes to the pathogenesis of heart failure, including defects in the substrate oxidation, and the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS). However, whether such changes occur early in the development of heart failure, and are potentially involved in the pathologic events that lead to cardiac dysfunction is unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

30 Samples

Download data: CEL

(Submitter supplied) Mechanical unloading by ventricular assist devices (VAD) leads to significant gene-expression changes often summarized as reverse remodeling. However, little is known on individual transcriptome changes during VAD-support and its relationship to non-failing hearts (NF). In addition no data are available for the transcriptome regulation during non-pulsatile VAD-support. Therefore we analysed the gene-expression patterns of 30 paired samples from VAD-supported (including 8 non-pulsatile VADs) and 8 non-failing control hearts (NF) using the first total human genome-array available. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

68 Samples

Download data: CEL, TXT

(Submitter supplied) Plasma miRNAs associated with LVRR in humans are dysregulated in animal HF and target clusters of genes involved in mechanisms implicated in HF. A translational approach integrating human HF, bioinformatics, and model systems may uncover novel pathways involved in HF.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24497

64 Samples

Download data

(Submitter supplied) Aims: To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium. Methods and Results: Hand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic days (E) 9.5-13.5. Hand gene dosage plays an important role in ventricular morphology and the contribution of Hand1 to congenital heart defects requires further interrogation. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

7 Samples

Download data: XLSX

(Submitter supplied) Altered myocardial gene expression from heart failure (HF) has mostly been identified by single-point analysis of end-stage disease. This may miss earlier changes in gene expression that are transient and/or directionally opposite to those observed later. By sampling left ventricular myocardial tissue at different time points in a mouse model of cardiomyopathy, we examined differentially expressed transcripts between non-failing controls, early-HF (2 and 3 days after cardiac insult), peak-HF (10 days) and after recovery from HF (28 days). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5469

Platform:

GPL6885

19 Samples

Download data: TXT

Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets

Platform:

GPL6885

Series:

GSE54681

19 Samples

Download data