Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 14

1.

Upregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema

(Submitter supplied) HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloproteinases may be associated with the emphysema of HIV1+ smokers. To test this hypothesis, microarray analysis was used to screen which MMP genes were expressed by AM isolated by bronchoalveolar lavage (BAL) of HIV1+ smokers with early emphysema. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE10038
ID:
200010038
2.

MMP28 is a key contributor to emphysema pathogenesis

(Submitter supplied) Chronic Obstructive Pulmonary Disease, which is comprised of chronic bronchitis and emphysema, is a leading cause of morbidity and mortality. Because tissue destruction is the prominent characteristic of emphysema, extracellular proteinases, particularly those with elastolytic ability, are often considered to be key drivers in this disease. Several human and mouse studies have implicated roles for matrix metalloproteinases (MMPs), particularly macrophage-derived proteinases, in COPD pathogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: TXT
Series
Accession:
GSE93898
ID:
200093898
3.

Overexpression of the Apoptotic Cell Removal Receptor, MERTK, in Alveolar Macrophages of Cigarette Smokers

(Submitter supplied) Mononuclear phagocytes play an important role in the removal of apoptotic cells by expressing cell surface receptors that recognize and remove apoptotic cells. Based on the knowledge that cigarette smoking is associated with increased lung cell turnover, we hypothesized that alveolar macrophages (AM) of normal cigarette smokers may exhibit enhanced expression of apoptotic cell removal receptor genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3496
Platform:
GPL570
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE8823
ID:
200008823
4.
Full record GDS3496

Alveolar macrophages of cigarette smokers

Analysis of alveolar macrophages from cigarette smokers. Cigarette smoking is associated with increased lung cell turnover. Mononuclear phagocytes, such as macrophages, play an important role in the removal of apoptotic cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 other sets
Platform:
GPL570
Series:
GSE8823
24 Samples
Download data: CEL, CHP
5.

A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking

(Submitter supplied) This series represents alveolar macrophages from a mouse model of emphysema, deletion of the integrin beta6 Keywords: parallel sample
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1874
Platform:
GPL1792
15 Samples
Download data: TIFF
Series
Accession:
GSE2255
ID:
200002255
6.

isolated alveolar macrophages

(Submitter supplied) This series represents isolated alveolar macrophages from human subjects. Keywords: parallel sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1269
Platform:
GPL570
45 Samples
Download data: CEL
Series
Accession:
GSE2125
ID:
200002125
7.
Full record GDS1874

Integrin beta-6 deficiency model of emphysema: alveolar macrophage

Analysis of alveolar macrophages of integrin beta-6 (Itgb6) deficient animals treated with doxycycline. Itgb6 mutants develop emphysema. Effect of TGFbeta transgene induction to suppress the effect of the Itgb6 mutation also examined.
Organism:
Mus musculus
Type:
Expression profiling by array, log ratio, 3 genotype/variation sets
Platform:
GPL1792
Series:
GSE2255
15 Samples
Download data: TIFF
8.
Full record GDS1269

Cigarette smoking effect on alveolar macrophage

Analysis of alveolar macrophages from 15 cigarette smokers, 15 non-smokers and 15 asthmatics. Results suggest that alveolar macrophage activation induced by smoking contributes to emphysema.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent sets
Platform:
GPL570
Series:
GSE2125
45 Samples
Download data: CEL
9.

Gene expression in alveolar macrophages from phenotypically normal smokers compared to non-smokers

(Submitter supplied) Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundant evidence that alveolar macrophages (AM) play an important role. Based on the concept that COPD is a slow-progressing disorder likely involving multiple mediators released by AM activated by cigarette smoke, the present study focuses on the identification of previously unrecognized genes that may be linked to early events in the molecular pathogenesis of COPD, as opposed to factors associated with the presence of disease. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1436
Platform:
GPL80
10 Samples
Download data: CEL, EXP
Series
Accession:
GSE3212
ID:
200003212
10.
Full record GDS1436

Cigarette smoking effect on alveolar macrophages

Anlaysis of alveolar macrophages of 5 phenotypically normal smokers who consume ~20 packs cigarettes/year. Smoking is the leading cause of respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). Provides insight into early events in molecular pathogenesis of COPD.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 stress sets
Platform:
GPL80
Series:
GSE3212
10 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS1436
ID:
1436
11.

Genes Associated with MUC5AC Expression in the Human Airway Epithelium

(Submitter supplied) To help define the genes associated with mucus synthesis and secretion in the human small airway epithelium, we hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, a major secretory mucin and the major component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production / secretion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
132 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE34450
ID:
200034450
12.

Decreased Expression of Intelectin 1 in The Human Airway Epithelium of Smokers Compared to Nonsmokers

(Submitter supplied) Lectins are proteins present on cell surfaces or as shed extracellular proteins that function in innate immune defense as phagocytic receptors to recognize specific bacterial cell wall components. Based on the knowledge that cigarette smoking is associated with increased risk of bacterial infection, we hypothesized that cigarette smoking may modulate the expression of lectin genes in the airway epithelium. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
87 Samples
Download data: CEL, CHP
Series
Accession:
GSE10006
ID:
200010006
13.

Transcriptomic analysis of breast cancer

(Submitter supplied) Transcriptomic analysis of fresh breast cancer tissue versus normal tissues. The Study comprising 45 Saudi-Arabian subjects was designed to take advantage of transcriptomics to prospectively explore the roles of lifestyle and genetic susceptibility in the occurrence of breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
50 Samples
Download data: CEL, TXT
Series
Accession:
GSE36295
ID:
200036295
14.

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue Destructive Phenotype

(Submitter supplied) While the survival rate of HIV-infected individuals has dramatically improved with the development of highly active anti-retroviral therapy, HIV-infected individuals have an increased risk for chronic disorders, including the development of COPD, manifesting as emphysema. The mechanisms of HIV-associated emphysema are not understood. Based on the knowledge that human airway basal cells (BC) function as stem/progenitor cells capable of differentiation into specialized ciliated and secretory cells during natural turnover and repair in response to injury, we hypothesized that HIV interacts with, and consequently induces pathologic programming of the BC that contributes to the development of emphysema.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE85538
ID:
200085538
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_6105762fc076fa235c572803|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center