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Links from GEO DataSets

Items: 20

1.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
2.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
3.

27_RA_RMA_Jan04_time_course

(Submitter supplied) This series represents murine dorsal neural tube bisected along the midline with one half from each embryo used for control and the other half treated with 10-6M RA dissolved in ethanol for 6, 12, 24 or 48 h. For 6 h exposures, the explants were cultured overnight on fibronectin coated 35mm dishes (Biocoat, Becton Dickinson Labware, Bedford, MA) in DMEM with 10% horse serum in order to allow for sufficient outgrowth of neural crest cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS773
Platform:
GPL81
27 Samples
Download data: CEL, EXP
Series
Accession:
GSE1588
ID:
200001588
4.
Full record GDS773

Retinoic acid teratogenic effect on cranial neural crest: time course

Expression profiling of cranial neural crest exposed to 1 uM retinoic acid (RA) at various lengths of time up to 48 hours. Neural crest obtained from 8.5 days postcoitum ICR embryos. Results provide insight into developmental pathways affected upon exposure to teratogenic concentrations of RA.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 4 time sets
Platform:
GPL81
Series:
GSE1588
27 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS773
ID:
773
5.

cAMP-induced differentiation of endometrial stromal cells

(Submitter supplied) Timecourse of cAMP-induced decidualization of endometrial stromal cells. Keywords: time-course
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
12 Samples
Download data
Series
Accession:
GSE403
ID:
200000403
6.

Identification of novel transcriptional networks in response to the treatment D3T (3H-1, 2-dithiole-3-thione)

(Submitter supplied) 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental carcinogens, prevent neoplasia, and to elicit other protective effects. However, a comprehensive view of the regulatory pathways induced by this compound has not yet been elaborated. Fischer F344 rats were gavaged daily for 5 days with vehicle or D3T (0.3 mmol/kg). The global changes of gene expression in liver were measured with Affymetrix RG-U34A chips. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1484
Platform:
GPL85
8 Samples
Download data
Series
Accession:
GSE3173
ID:
200003173
7.
Full record GDS1484

Anticarcinogen 3H-1, 2-dithiole-3-thione effect on liver

Analysis of livers of animals treated with 3H-1, 2-dithiole-3-thione (D3T). D3T blocks carcinogenesis through induction of phase 2 enzymes that enhance the detoxification of xenobiotic compounds. Results provide insight into the regulatory pathways affected by D3T.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL85
Series:
GSE3173
8 Samples
Download data
DataSet
Accession:
GDS1484
ID:
1484
8.

Gene profiling of mouse brain infected with scrapie strain 22A_End-point analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platforms:
GPL7118 GPL7121
29 Samples
Download data: TXT
Series
Accession:
GSE12354
ID:
200012354
9.

Brain_22A-Scrapie_End-point_PR06-11-to-14_using_GPL7121

(Submitter supplied) Examining the transcriptional change in whole mouse (VM) brain miRNA expression during prion (22A) induced neurodegeneration in order to identify miRNAs that are differentially expressed. MicroRNAs (miRNAs) are small, non-coding RNA molecules which are emerging as key regulators of numerous cellular processes. Compelling evidence links miRNAs to the control of neuronal development and differentiation, however, little is known about their role in neurodegeneration. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL7121
17 Samples
Download data: TXT
Series
Accession:
GSE12322
ID:
200012322
10.

Brain_22A-Scrapie_End-point_PR04-39-to-46_using_GPL7118

(Submitter supplied) Examining the transcriptional change in whole mouse (VM) brain miRNA expression during prion (22A) induced neurodegeneration in order to identify miRNAs that are differentially expressed. MicroRNAs (miRNAs) are small, non-coding RNA molecules which are emerging as key regulators of numerous cellular processes. Compelling evidence links miRNAs to the control of neuronal development and differentiation, however, little is known about their role in neurodegeneration. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL7118
12 Samples
Download data: TXT
Series
Accession:
GSE12321
ID:
200012321
11.

Laser microdissection and microarray analysis of the hippocampus of Rasgrf1 knockout mice

(Submitter supplied) We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcriptomes of macrodissected and microdissected samples showed that the LCM samples allowed detection of significantly higher numbers of differentially expressed genes, with higher statistical rates of significance. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2816
Platform:
GPL339
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE8425
ID:
200008425
12.
Full record GDS2816

Ras-GRF1 deficiency effect on the hippocampus

Analysis of laser capture microdissected hippocampi of mutants lacking Ras-GRF1. Ras-GRF-1 is a guanine nucleotide exchange factor predominantly expressed in the central nervous system of mammals. Results provide insight into role of Ras-GRF1 in neural processes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE8425
6 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS2816
ID:
2816
13.

Global gene expression pattern of human brain neuronal (SH-SY5Y) cell lines exposed to sarin (GB).

(Submitter supplied) Total RNA was isolated from sarin (GB) treated (n = 6 flasks) untreated (control n = 6) neuronal (SH-SY5Y) cell lines using RNeasy® mini kit. The preparation and processing of labeled, fragmented cRNA for hybridization has been performed according to the manufacturer’s protocols (Affymetrix, Santa Clara, CA). (Biological Replicates for each time points). Keywords: Time-course
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
18 Samples
Download data
Series
Accession:
GSE2732
ID:
200002732
14.

Early responsive genes in human amnion epithelial FL cells induced by N-methyl-N’-nitro-N-nitrosoguanidine

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL97
16 Samples
Download data: CEL, EXP
Series
Accession:
GSE8602
ID:
200008602
15.

Expression data from silkworm posterior silk glands at the late larval stages

(Submitter supplied) The silkworm silk gland is one of the most efficient protein synthesis systems among all organisms. Its amazingly efficient protein synthesis makes the silk gland a desirable object for basic studies on gene expression and regulation and for biotechnological applications. At the early stages of the fifth (final) instar, the cellular structures necessary for the synthesis of fibroin are rapidly formed, and at the later stage the synthesis of fibroin proceeds at a maximum rate. more...
Organism:
Bombyx mori
Type:
Expression profiling by array
Platform:
GPL10763
15 Samples
Download data: LSR
Series
Accession:
GSE26172
ID:
200026172
16.

Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes

(Submitter supplied) The complex response of murine macrophages to infection with Streptococcus pyogenes was investigated at the level of gene expression using a high-density oligomer microarray. More than 400 genes were identified as being differentially regulated. Many of the up-regulated genes encoded molecules were involved in immune response and inflammation, transcription, signalling, apoptosis, cell cycle, electron transport and cell adhesion. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
2 Samples
Download data: CEL
Series
Accession:
GSE7769
ID:
200007769
17.

Ethanol treated vs paired control

(Submitter supplied) 6 ethanol treated animals with their paired controls Keywords: repeat sample
Organism:
Rattus norvegicus; unidentified
Type:
Expression profiling by array
Platform:
GPL2000
12 Samples
Download data
Series
Accession:
GSE2718
ID:
200002718
18.

Chronic Rosiglitazone Mouse Aorta

(Submitter supplied) To better understand what genes are regulated by PPAR gamma, an experimental dataset was generated by microarray analysis, in duplicate, of pooled aortic mRNA isolated from adult male mice (C57BL/6J strain) treated for 21 days with a PPAR gamma agonist (rosiglitazone) or vehicle. Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS859
Platform:
GPL81
4 Samples
Download data
Series
Accession:
GSE1011
ID:
200001011
19.
Full record GDS859

Peroxisome proliferator-activated receptor-gamma target genes in aorta

Analysis of aorta isolated from adult male C57BL/6J treated for 21 days with a peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist rosiglitazone or vehicle. Diminished activity of PPARgamma may play role in pathogenesis of hypertension and vascular dysfunction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL81
Series:
GSE1011
4 Samples
Download data
DataSet
Accession:
GDS859
ID:
859
20.

Endothelial cells and atorvastatin

(Submitter supplied) Rationale: Immortalized cells may exhibit important differences relative to their primary cell counterparts. Microarrays were used compare primary human umbilical vein endothelial cells (HUVECs) and the immortalized HUVEC cell line EA.hy926, in their response to inhibition of the mevalonate pathway by a HMG-CoA reductase inhibitor (atorvastatin). The effects of atorvastatin were reversed by the addition of mevalonate, to subtract non-specific changes in gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1630
Platform:
GPL96
16 Samples
Download data: CEL, EXP
Series
Accession:
GSE2450
ID:
200002450
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