GEO DataSets

(Submitter supplied) We used microarray analyses in adult female zebrafish (Danio rerio) to identify metabolic pathways regulated by starvation in two key organs that 1) serve biosynthetic and energy mobilizing functions (liver) and 2) consume energy and direct behavioral responses (brain). Starvation affected the expression of 574 transcripts in the liver, indicating an overall decrease in metabolic activity, reduced lipid metabolism, protein biosynthesis and proteolysis, and cellular respiration, and increased gluconeogenesis. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

18 Samples

Download data: CEL

(Submitter supplied) BACKGROUND: Fast, efficiently growing animals have increased protein synthesis and/or reduced protein degradation relative to slow, inefficiently growing animals. Consequently, minimizing the energetic cost of protein turnover is a strategic goal for enhancing animal growth. Characterization of gene expression profiles associated with protein turnover would allow us to identify genes that could potentially be used as molecular biomarkers to select for germplasm with improved protein accretion. more...

Organism:

Salmo salar; Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL3976

4 Samples

Download data: CSV

(Submitter supplied) Domesticated animal populations often show profound reductions in predator avoidance and fear-related behavior compared to wild populations. These reductions are remarkably consistent and have been observed in a diverse array of taxa including fish, birds, and mammals. Experiments conducted in common environments indicate that these behavioral differences have a genetic basis. In this study, we quantified differences in fear-related behavior between wild and domesticated zebrafish strains and used microarray analysis to identify genes that may be associated with this variation. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL1319

16 Samples

Download data: CEL

(Submitter supplied) Experiment exposed adult male zebrafish to 10ng/L 17-alpha ethinylestradiol for three weeks. Gene expression profiling of liver and telencephalon following exposure. Keywords: estrogenic exposure

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL3548

8 Samples

Download data

(Submitter supplied) Here, we certified zebrafish to be a suitable model for the compensatory growth study. After a 3-weeks fasting, recovered for 3 days, 10 days and 15 days were chose as the initial, middle and late sampling sites for compensatory growth analysis, and liver samples of each time point were chose for the microarray analysis.At the same time, zebrafish fed ad libitum, as well as fasting for 3 weeks were also added to the microarray research.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Oncorhynchus mykiss; Oncorhynchus tshawytscha; Osmerus mordax; Salmo salar; Coregonus clupeaformis

Type:

Expression profiling by array

Platform:

GPL2716

44 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Osmerus mordax; Oncorhynchus mykiss; Coregonus clupeaformis; Oncorhynchus tshawytscha; Salmo salar

Type:

Expression profiling by array

Platform:

GPL2716

12 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Salmo salar; Oncorhynchus tshawytscha

Type:

Expression profiling by array

Platform:

GPL2716

14 Samples

Download data: TXT

(Submitter supplied) Domestication has produced faster-growing strains of animals for use in agriculture, but selection has been applied with little knowledge of the underlying genetic changes that arose throughout the process. Mammals and birds have been domesticated for thousands of years whereas fish have been domesticated only recently; therefore, wild progenitor strains remain for comparison. Rainbow trout (Oncorhynchus mykiss) have undergone intensive selection and domesticated strains grow more rapidly than extant wild strains. more...

Organism:

Oncorhynchus tshawytscha; Oncorhynchus mykiss; Salmo salar; Osmerus mordax; Coregonus clupeaformis

Type:

Expression profiling by array

Platform:

GPL2716

18 Samples

Download data: TXT

(Submitter supplied) Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects Posilac® (Monsanto Co., St. Louis, MO), a recombinant bovine somatotropin, on tissue transcript levels. Transcript abundance was measure in liver and muscle using the GRASP 16 K cDNA microarray. A selection of the genes identified as altered with the microarray, and also transcripts for insulin-like growth factors, growth hormone receptors (GHR) and myostatins were measured by realtime PCR in the liver, muscle, brain, kidney, intestine, stomach, gill and heart. more...

Organism:

Oncorhynchus mykiss; Salmo salar

Type:

Expression profiling by array

Platform:

GPL3976

16 Samples

Download data: TXT

(Submitter supplied) Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL7301

32 Samples

Download data: GPR, TXT

(Submitter supplied) Liver plays a key role during the stress adaptation process. Therefore to understand the molecular adjustments that occur in fish to counter the stress during transport, transcriptional changes in zebrafish liver were analyzed with a 4x44K oligo array using total RNA extracted from fish prior to transport (basal), immediately after packing (0 h) and during the mock transport (48 and 72 h).

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

16 Samples

Download data: TXT

(Submitter supplied) Sexual reproduction is a complex process involving multiple pathways. In this study, we aimed at investigating gene expression profiles underlying gender specificity in the zebrafish. To do so, we analyzed the transcriptome of the gonads of breeding fish and queried the gene expression profiles for significant differences between the genders and also between stages of gonad development. Major differences in gene expression profiles between genders were encountered at the level of the gonads. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL4375

11 Samples

Download data: TXT

(Submitter supplied) Chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) is a broad spectrum fungicide used extensively in agricultural crops . The aim of this study is to analyse the effects of Chorothalonil on the gene expression profiles in zebrafish (Danio rerio), exposed to two concentrations of the fungicide in the water. Nominal concentrations were 1) Low 0.007mg/l (environmentally relevent) and 2) High 0.035mg/ml . more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14688

15 Samples

Download data: TXT

(Submitter supplied) Full title: Mercury-Induced Hepatotoxicity in Zebrafish: In Vivo Mechanistic Insights from Transcriptome Analysis, Phenotype Anchoring and Targeted Gene Expression Validation In this study, we performed microarray-based expression profiling on liver of zebrafish exposed to 200 µg/L of mercuric chloride for 8-96 h, to identify global transcriptional programs and biological pathways involved in mercury-induced adaptive responses under in vivo environment.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL2715

24 Samples

Download data: TXT

(Submitter supplied) In the context of replacing fish meal and fish oil in feeds for aquaculture, rainbow trout alevins received from first-feeding onwards, one of the three experimental diets: V (100% plant-based), C (mix of FM-FO & plant ingredients) or M (100% FM-FO based). The long term effects of such dietary replacement on the intestinal (mid gut) and hepatic transcriptome were studied in juveniles after a 7-month feeding trial at 7°C.

Organism:

Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL15840

48 Samples

Download data: TXT

(Submitter supplied) In the present study, we employed the RNA sequencing platform to examine the molecular response of zebrafish liver to arsenic exposure and carry out detailed transcriptomic analyses for further understanding of molecular toxicity. We found that several important biological processes were perturbed by arsenic exposure, including oxidation reduction, translation, iron ion transport, cell redox and homeostasis, as well as related pathways in metabolism and diseases. more...

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16034

2 Samples

Download data: TXT

(Submitter supplied) Ectothermic vertebrates are different from mammals that are sensitive to hypothermia and they have to maintain core temperature for survival. Why and how ectothermic animals can survive, grow and reproduce in low temperature have been for a long time a scientifically challenging and important inquiry to biologists. We used a microarray to profile the gill transcriptome in zebrafish (Danio rerio) after exposure to low temperature. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL5182

6 Samples

Download data: CSV, TXT

(Submitter supplied) Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and its occurrence is associated with a number of environmental factors including ingestion of the dietary contaminant aflatoxin B1 (AFB1). While etiology of the disease is relatively well defined, the molecular mechanisms of tumorigenesis are poorly understood. In this study, we examined, for the first time, gene expression of AFB1-induced HCC by microarray in the rainbow trout (Oncorhynchus mykiss) tumor model. more...

Organism:

Oncorhynchus mykiss

Type:

Expression profiling by array

Platform:

GPL2096

12 Samples

Download data

(Submitter supplied) We report the effects of exposure to the endocrine disruptor nonylphenol (NP) on transcriptome modification in the livers of in vivo Zebrafish. Our data indicate changes in fatty acid metabolism and inflammation, pathways associated with the development of Non-Alcoholic Fatty Liver Disease (NAFLD).

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15583

6 Samples

Download data: TXT