Similar studies for GEO DataSets (Select 200011661) - GEO DataSets

Select item 2000116611.

Cardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo

(Submitter supplied) Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypically normal whereas mice lacking both proteins develop a spontaneous cardiac and skeletal muscle hypertrophy indicating cooperative control of muscle mass by MuRF1 and MuRF2. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2876
19 Samples

Download data: GPR

Series

Accession:: GSE11661

ID:: 200011661

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000145122.

Muscle Ring Finger 1 (MuRF1) and MuRF2 are Necessary but Functionally Redundant During Developmental Cardiac Growth and Regulate E2F1-Mediated Gene Expression In Vivo

(Submitter supplied) Muscle ring finger (MuRF) proteins have been implicated in the transmission of mechanical forces to nuclear cell signaling pathways through their association with the sarcomere. We recently reported that MuRF1, but not MuRF2, regulated pathologic cardiac hypertrophy in vivo. This was surprising since MuRF1 and MuRF2 interact redundantly with sarcomeric proteins in yeast two hybrid studies, and form both homo- and hetero-dimers with each other. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
16 Samples

Download data: TXT

Series

Accession:: GSE14512

ID:: 200014512

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000823453.

Muscle Ring Finger-1 regulation of right-sided heart transcriptional responses to hypoxia in vivo.

(Submitter supplied) To determine the role of cardiomyocyte muscle ring finger-1 (MuRF1) in vivo, we employed whole genome microarray expression profiling as a discovery platform to identify genes differentially regulated by MuRF1 using MuRF1-/- and alphaMHC (cardiomyocyte-specific) MuRF1 transgenic mice in a model of pulmonary hypertension-induced right sided heart failure. Mice were placed in hypoxia chambers set at 10.0% oxygen (partial pressure of oxygen roughly 65 mmHg in Albuquerque) and monitored both by the digital feedback control system (Biospherix, Colorado) as well as by a secondary O2/CO2 monitor (O2Cap, OxiGraf, Inc.; Mountain View, CA). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
17 Samples

Download data: TXT

Series

Accession:: GSE82345

ID:: 200082345

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000106264.

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies

(Submitter supplied) Under various pathophysiological muscle-wasting conditions like diabetes and starvation, a family of ubiquitin ligases, including MuRF1 (Muscle specific RING-Finger protein 1), are induced to target muscle proteins for degradation via ubiquitination. In an attempt to identify the in vivo targets of MuRF1 we have generated transgenic mouse lines overexpressing MuRF1 in a skeletal muscle specific fashion. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6526
4 Samples

Download data: CEL

Series

Accession:: GSE10626

ID:: 200010626

Select item 2000684805.

MuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.

(Submitter supplied) MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
20 Samples

Download data: TXT

Series

Accession:: GSE68480

ID:: 200068480

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000033836.

Analysis of Akt1 activation in transgenic mouse hearts show expression profiles associated with hypertrophy and failure

(Submitter supplied) To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 weeks) of Akt1 resulted in completely reversible hypertrophy with maintained contractility. In contrast, chronic Akt1 activation (6 weeks) induced extensive cardiac hypertrophy, severe contractile dysfunction, and massive interstitial fibrosis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS2304 GDS2308
Platforms:: GPL340 GPL339
36 Samples

Download data

Series

Accession:: GSE3383

ID:: 200003383

Select item 23087.

Akt1 serine-threonine protein kinase activation effect on the heart (MG-430B)

Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.