GEO DataSets

(Submitter supplied) Soman (O-Pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes profound inhibition of the critical enzyme acetylcholinesterase, resulting in excessive levels of the neurotransmitter acetylcholine. Excessive acetylcholine levels cause convulsions, seizures, and respiratory distress. The initial cholinergic crisis can be overcome by rapid anti-cholinergic therapeutic intervention, resulting in increased survival. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4940

Platform:

GPL1355

38 Samples

Download data: CEL

Analysis of hippocampi of Sprauge-Dawley males for up to 168 hours following exposure to the acetylcholinesterase inhibitor soman. Soman is a potent neurotoxicant. Results provide insight into the molecular pathogenesis of soman-induced neurodegeneration.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 agent, 10 time sets

Platform:

GPL1355

Series:

GSE13428

38 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) cDNA microarray study of gene expression changes in whole blood from LPS treated rats, 2 and 6 hours after I.P. injection of 5 mg/kg Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1344

12 Samples

Download data: TIFF

(Submitter supplied) Male Sprague-dawley rats were exposed to saline, isopropyl alcohol, 1mg/kg, 3mg/kg or 6 mg/kg sulfur mustard for 30 min, 1 hr, 3 hr, 6 hr, or 24 hr before analysis of lung tissue by oligonucleotide array analysis. Keywords = sulfur mustard Keywords = rat Keywords = lung Keywords = bis-(2-chloroethyl) sulfide Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1027

Platform:

GPL341

154 Samples

Download data: CEL, EXP, RPT

Analysis of lungs from Sprague Dawley males following injection with 1, 3, or 6 mg/kg of sulfur mustard (SM) bis-(2-chloroethyl) sulfide, a carcinogenic alkylating agent. Lungs examined at various time points up to 24 hours postinjection. Results provide insight into SM-induced lung injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 dose, 2 protocol, 5 time sets

Platform:

GPL341

Series:

GSE1888

154 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasures to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

335 Samples

Download data: CEL

(Submitter supplied) Sulfur mustard (SM) is a potent alkylating agent. We are developing medical countermeasures to reduce the injury caused by SM exposure. Screening in the mouse ear vesicant model has identified three effective compounds: dimercaprol (British anti-lewisite), indomethacin, and octyl homovanillamide (OHV). To identify gene expression changes that correlate with compound efficacy we used oligonucleotide microarrays to compare gene expression profiles in vehicle-exposed skin, SM-exposed skin, and skin pretreated with each compound before SM exposure. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

107 Samples

Download data

(Submitter supplied) Carbonyl chloride (phosgene) is a toxic industrial compound (TIC) widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 hr), potentially life-threatening pulmonary edema and irreversible acute lung injury. A genomic approach was utilized to investigate the molecular mechanism of phosgene-induced lung injury. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1244

Platform:

GPL339

104 Samples

Download data: CEL, CHP, EXP, RPT

Analysis of lungs exposed to the toxic industrial compound carbonyl chloride (phosgene). Phosgene exposure results in pulmonary edema and acute lung injury. Lungs examined at several time points up to 72 hours after exposure. Provides insight into molecular events affected in phosgene-injured lungs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 9 time sets

Platform:

GPL339

Series:

GSE2565

104 Samples

Download data: CEL, CHP, EXP, RPT

(Submitter supplied) RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5282 GDS5283

Platform:

GPL1355

48 Samples

Download data: CEL

Analysis of livers of males for up to 48 hours after treatment with a single, oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the liver.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 dose, 4 time sets

Platform:

GPL1355

Series:

GSE12196

24 Samples

Download data: CEL

Analysis of cerebral cortices of males for up to 48 hours after treatment with an oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the brain.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 dose, 4 time sets

Platform:

GPL1355

Series:

GSE12196

24 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with C60 fullerene particles was employed to gain insights into these molecular events.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

22 Samples

Download data: TXT

(Submitter supplied) Although major differences in the response of tissues were documented in the literature, the molecular mechanisms underlying tissue radiosensitivity are still fragmentary and need to be study more thoroughly. To this end, a genome wide analysis strategy was used to investigate changes in gene expression in the liver following exposition to ionizing radiation. This follows the tissue survey that was previously initiated with other organs and tends to obtain a comprehensive picture of the molecular events underlying tissue radio sensitivity. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL4376 GPL4377

16 Samples

Download data: GPR

(Submitter supplied) SAGE profile of the rat superior olivary complex (SOC). Rats were 60 days old (P60). Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by SAGE

Platform:

GPL23

1 Sample

Download data

(Submitter supplied) Total RNA was isolated from sarin (GB) treated (n = 6 flasks) untreated (control n = 6) neuronal (SH-SY5Y) cell lines using RNeasy® mini kit. The preparation and processing of labeled, fragmented cRNA for hybridization has been performed according to the manufacturer’s protocols (Affymetrix, Santa Clara, CA). (Biological Replicates for each time points). Keywords: Time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

18 Samples

Download data

(Submitter supplied) Gene expression profiling of the rat lung after whole-body inhalation exposure to C60 fullerene and ultrafine nickel oxide (Uf-NiO) particles as a positive control were employed to gain insights into these molecular events.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

6 Samples

Download data: TXT

(Submitter supplied) NAP - neuroprotective peptide demonstrates increase in neuronal survival when injected into the hippocampus of rats in the model of epilepsy Microarray analysis was used to understand the expression of genes following KA treatment and the changes in gene expression following KA+NAP treatment Keywords: stress response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

4 Samples

Download data: CEL