Similar studies for GEO DataSets (Select 200013548) - GEO DataSets

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Items: 3

Select item 2000135481.

Expression data from human cancer cells treated with UPR modulators under ER stress conditions

(Submitter supplied) The unfolded protein response (UPR) is a cellular defense mechanism against glucose deprivation, a cell condition that occurs in solid tumors. A key feature of the UPR is the activation of the transcription program that allows the cell to cope with endoplasmic reticulum (ER) stress. We used micoarrays to show that the UPR transcription program is disrupted by the antitumor macrocyclic compound versipelostatin (VST) and antidiabetic biguanides metformin, buformin and phenformin, depending on cellular glucose availability. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
42 Samples

Download data: CEL

Series

Accession:: GSE13548

ID:: 200013548

Select item 2000329112.

Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.

(Submitter supplied) Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We found that compound C (also known as dorsomorphin) prevented the UPR and exerted enhanced cytotoxicity during glucose deprivation. The UPR-inhibiting activity of compound C was not associated with either AMPK or BMP signaling inhibition.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE32911

ID:: 200032911

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Select item 2000299033.

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

(Submitter supplied) Oxidized phospholipids are thought to promote atherogenesis by stimulating endothelial cells (ECs) to produce inflammatory cytokines, such as IL-8. In studies with mouse models, we previously demonstrated that genetic variation in inflammatory responses of endothelial cells to oxidized lipids contributes importantly to atherosclerosis susceptibility. We now show that similar variations occur in cultured aortic ECs derived from multiple heart transplant donors. more...