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Links from GEO DataSets

Items: 7

1.

Culture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo

(Submitter supplied) Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1+ endothelial cells (ppMBMECs) were compared with primary MBMECs (pMBMEC) cultured in the presence or absence of glial cells, and with b.End5 endothelioma cell-line. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8059
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE14375
ID:
200014375
2.

Rat brain microvessel SAGE

(Submitter supplied) SAGE analysis of genes expressed in rat brain microvessels. Keywords: Novel gene identification
Organism:
Rattus norvegicus
Type:
Expression profiling by SAGE
Platform:
GPL23
1 Sample
Download data
Series
Accession:
GSE3696
ID:
200003696
3.

Transcript profiling of oestrogen treatment of primary human neuronal and glial cell cultures

(Submitter supplied) The purpose of this experiment was to identify oestrogen regulated genes in human primary cell cultures of neuronal and glial cells modelling the developing human nervous system. We were especially interested in genes involved in proliferation, differentiation and migration of neuronal cells and genes involved in or linked to neurodegenerative diseases. We have therefore assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of oestrogen treated human neuronal/ glial cell cultures. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE10097
ID:
200010097
4.

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes

(Submitter supplied) Background: Endothelial progenitor cells play an important role in vascular wall repair. Patients with type 1 diabetes have reduced levels of endothelial progenitor cells of which their functional capacity is impaired. Reduced nitric oxide bioavailability and increased oxidative stress play a role in endothelial progenitor cell dysfunction in these patients. Folic acid, a B-vitamin with anti-oxidant properties, may be able to improve endothelial progenitor cell function. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3656
Platform:
GPL2700
32 Samples
Download data: TXT
Series
Accession:
GSE17635
ID:
200017635
5.
Full record GDS3656

Folic acid effect on endothelial progenitor cells of type 1 diabetes patients

Analysis of endothelial progenitor cells (EPCs) from patients with type 1 diabetes (T1D) before and 4 weeks of dietary folic acid (FA) supplementation. EPCs are involved in vascular wall repair. T1D results in reduced circulating EPCs. Results provide insight into the effect of FA on EPC function.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state, 12 individual sets
Platform:
GPL2700
Series:
GSE17635
32 Samples
Download data
6.

Gene expression in the liver following exposition to 1Gy ionizing radiation

(Submitter supplied) Although major differences in the response of tissues were documented in the literature, the molecular mechanisms underlying tissue radiosensitivity are still fragmentary and need to be study more thoroughly. To this end, a genome wide analysis strategy was used to investigate changes in gene expression in the liver following exposition to ionizing radiation. This follows the tissue survey that was previously initiated with other organs and tends to obtain a comprehensive picture of the molecular events underlying tissue radio sensitivity. more...
Organism:
Rattus norvegicus; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL4376 GPL4377
16 Samples
Download data: GPR
Series
Accession:
GSE5994
ID:
200005994
7.

The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation

(Submitter supplied) The immortalized mouse hypothalamic cell line N25/2 was treated with medium containing amino acids or medium lacking all amino acids for 1, 2, 3, 5 or 16 hours, and the gene expression was measured for 28270 genes using microarray. Numerous transporters from the SLC family were transcriptionally regulated in response to changed amino acid levels.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE61402
ID:
200061402
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