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Links from GEO DataSets

Items: 20

1.

Expression profiles of epiblast stem cells and embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
20 Samples
Download data: TXT
Series
Accession:
GSE17202
ID:
200017202
2.

12h pathway stimulation / inhibition experiment in mouse ES cells

(Submitter supplied) This experiment records the transcriptional responses of mES cells (line OG2) to FGF/ERK stimulation in the presence of LIF, to LIF/STAT3 inhibition in the presence of an FGF/ERK inhibitor, and to combined FGF/ERK stimulation / LIF/STAT3 inhibition.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
4 Samples
Download data: TXT
Series
Accession:
GSE17136
ID:
200017136
3.

12h pathway stimulation / inhibition experiment in epiblast stem cells

(Submitter supplied) This experiment records the transcriptional responses of EpiSCs (line E3) to FGF/ERK inhibition, GSK3ß inhibition, LIF/STAT3 activation, as well as combined treatment for 12 hours each.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
5 Samples
Download data: TXT
Series
Accession:
GSE17134
ID:
200017134
4.

3h pathway stimulation / inhibition experiment in epiblast stem cells

(Submitter supplied) This experiment records the transcriptional responses of EpiSCs (line E3) to FGF/ERK inhibition, GSK3ß inhibition, LIF/STAT3 activation, as well as combined treatment for 3 hours each.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
5 Samples
Download data: TXT
Series
Accession:
GSE17133
ID:
200017133
5.

Expression profiles of ES cells, epiblast stem cells, and epiblast stem cells reverted to an ES-like state

(Submitter supplied) This analysis compares the expression profiles of CGR8 ES cells, E3 epiblast stem cells, and E3R cells (E3 EpiSCs reverted to an ES-like state).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE17132
ID:
200017132
6.

Expression profiles of two epiblast stem cell lines and one ES cell line

(Submitter supplied) This analysis compares the expression profiles of E3 epiblast stem cells (hybrid background), T9 EpiSCs (129 inbred background), and OG2 ES cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE17131
ID:
200017131
7.

Graded Nodal/Activin Signaling Governs ES Cell Fate Decisions via Differential Recruitment of Phospho-Smad2 to Oct4 and Distinct Target Gene Subsets

(Submitter supplied) Nodal and Activin are morphogens of the TGFbeta superfamily of signaling molecules that direct differential cell fate decisions in a dose- and distance-dependent manner. During early embryonic development the Nodal/Activin pathway is responsible for the specification of mesoderm, endoderm, node and mesendoderm. In contradiction to this drive towards cellular differentiation, the pathway also plays important roles in the maintenance of self-renewal and pluripotency in embryonic and epiblast stem cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
16 Samples
Download data: TXT
Series
Accession:
GSE23239
ID:
200023239
8.

Distinct developmental ground states of different epiblast stem cell lines determine pluripotency features

(Submitter supplied) Epiblast stem cells (EpiSC) are pluripotent stem cells derived from mouse postimplantation embryos between E5.5 to E7.5, a time window in which gastrulation commences. Therefore, EpiSC represent a valuable tool for studying mammalian postimplantation development in vitro. Beyond their pluripotent features, EpiSC can also be reprogrammed into a mouse embryonic stem cell-like (mESC) state. Published reports showed that EpiSC reversion requires transcription factor overexpression, while others suggest that applying stringent mESC culture conditions alone was sufficient to revert EpiSC to mESC-like cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
7 Samples
Download data: TXT
Series
Accession:
GSE28270
ID:
200028270
9.

Developmental equivalence of epiblast stem cells (EpiSCs)

(Submitter supplied) Epiblast stem cells (EpiSCs) were derived from the epiblast or the ectoderm (epi/ect) of pre-gastrula stage to late-bud stage mouse embryos. To identify if the EpiSCs retain any original stage specific characteristics or which developmental stage of epi/ect they most closely related to, we performed microarray analysis to compare the gene expression profile of multiple EpiSC lines with that of epi/ect of 7 different stages.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
112 Samples
Download data: TXT
Series
Accession:
GSE46227
ID:
200046227
10.

Bmp4-induced differentiation of EpiSCs depends on Wnt signals

(Submitter supplied) We used RNA-Seq to analyse the interactions between Bmp4 and Wnt at a genome-wide level in EpiSCs treated for 48 hrs with Bmp4 and/or Wnt3a in the presence of Activin and bFGF.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE62205
ID:
200062205
11.

Endogenous Wnt proteins induce differentiation and loss of pluripotency in EpiSCs

(Submitter supplied) We compared the transcriptomes of EpiSCs maintained in the presence or absence of Wnt pathway inhibitor IWP2. We screened also our gene expression data for potential markers for genuine EpiSCs, maintained in the presence of Wnt inhibition and compared with ESC expression data. We compared the transcriptomes of EpiSCs maintained in the presence or absence of IWP2. The high level of Wnt-induced differentiation occurring in conventional EpiSC cultures may have interfered with the analysis of their characteristics. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE62155
ID:
200062155
12.

Activin/Nodal signalling controls divergent transcriptional networks in pluripotent and endoderm progenitors.

(Submitter supplied) Activin/Nodal signalling is necessary to maintain pluripotency of human Embryonic Stem Cells (hESCs) and to induce their differentiation towards endoderm. However, the mechanisms by which Activin/Nodal signalling achieves these opposite functions remain unclear. To unravel these mechanisms, we examined the transcriptional network controlled in hESCs by Smad2 and Smad3 which represent the direct effectors of Activin/Nodal signalling. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
5 Samples
Download data: BED, GFF, TXT
Series
Accession:
GSE19461
ID:
200019461
13.

Activin A in Combination with ERK1/2 MAPK Pathway Inhibition Sustains Propagation of Mouse Embryonic Stem Cells

(Submitter supplied) Activin/Nodal/TGF-β signaling pathway plays a major role in maintaining mouse epiblast stem cells (mEpiSCs). The mEpiSC medium which contains Activin A and bFGF induces differentiation of mouse embryonic stem cells (mESCs) to mEpiSC. Here we show that Activin A also has an ability to efficiently propagate mESCs without differentiation to mEpiSCs when combined with a MEK inhibitor PD0325901. mESCs cultured in Activin+PD retained high-level expression of naive pluripotency-related transcription factors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
3 Samples
Download data: CEL
Series
Accession:
GSE84679
ID:
200084679
14.

Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells

(Submitter supplied) The combination of Wnt pathway activation by the GSK3 inhibitor and ERK pathway inhibition by the MEK inhibitor, which is known as 2i is a well-established method to maintain mouse embryonic stem cell (mESC) self-renewal. Here we show that Activin A also has the ability to promote naive pluripotency of mESCs when combined with the MEK inhibitor PD0325901. mESCs were efficiently propagated in a medium containing both Activin A and the MEK inhibitor (PD0325901). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE74963
ID:
200074963
15.

The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

(Submitter supplied) The neural fate commitment of pluripotent stem cells requires repression of extrinsic inhibitory signals and activation of intrinsic positive transcription factors. However, it remains elusive how these two events are integrated to ensure appropriate neural conversion. Here, we show that Oct6 functions as an essential positive factor for neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
8 Samples
Download data: BED, TXT
Series
Accession:
GSE54569
ID:
200054569
16.

Global gene expression profile of mouse ESC-2i, EpiSC-CHIR/XAV and EpiSC-FGF2/activin

(Submitter supplied) The requirements for self-renewal differ between EpiSCs and ES cells and the underlying mechanism is largely unknown. Here we show that mouse EpiSCs can be efficiently derived and robustly propagated even from single cells, using two small-molecule inhibitors: CHIR99021 and XAV939. The whole-genome microarray analyses is performed to confirm the identity of EpiSC maintained in CHIR/XAV by comparing the expression profile in EpiSC-CHIR/XAV to those in ESC maintained in 2i and EpiSC maintained in FGF2/activin.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL
Series
Accession:
GSE31461
ID:
200031461
17.

Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL21273
22 Samples
Download data: BW
Series
Accession:
GSE92635
ID:
200092635
18.

RNA sequencing of Epiblast stem cells, nodal inhibited epiblast stem cells and embryonic samples

(Submitter supplied) To characterize the molecular properties of the EpiSCsS/F, we compared the transcriptome of EpiSCsS/F with that of EpiSCs and that of the epiblast cells sampled from embryos (and different parts of the embryo) at the cavity stage (E5.5) to early bud stage (E7.5)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
14 Samples
Download data: TXT
Series
Accession:
GSE92634
ID:
200092634
19.

Genome-wide maps of chromatin state in epiblast stem cells and nodal inhibited ebiblast stem cells

(Submitter supplied) We reported H3K4me3, H3K27ac and H3K27me3 histone modification in EpiSCs and Nodal inhibited EpiSCs(EpiSCS/F). Using ChIP sequencing, we demonstrate that the active modification of H3K4me3 and H3K27ac level are higher in EpiSCS/F, suggesting EpiSCsS/F were in an active chromatin state. Interestingly, H3K27me3, the supressive modification enriched more in EpiSCS/F down regulated genes, suggesting H3K27me3 plays pivital roles in regulating gene expression.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21273
8 Samples
Download data: BW
Series
Accession:
GSE92633
ID:
200092633
20.

FGF2 stimulation experiment with CF1 mouse embryonic fibroblasts

(Submitter supplied) Mouse embryonic fibroblasts stimulated with varying doses of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. Keywords: Growth factor stimulation experiment
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2421
Platform:
GPL4055
4 Samples
Download data: TXT
Series
Accession:
GSE5437
ID:
200005437
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