Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 16

1.

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells against SARS-CoV and DOHV infection

(Submitter supplied) Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection causes an immune-mediated disease. We have recently shown that SARS-CoV-induced epithelial Calu-3 cytokines could exacerbate and dampen host inflammatory and T cell responses, respectively, through modulating the functions of macrophages and dendritic cells, thereby suggesting that not only are lung epithelial cells the primary cells of SARS-CoV infection, but they also involve in initiating and orchestrating the host innate and adaptive immunity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
27 Samples
Download data: CEL
Series
Accession:
GSE17400
ID:
200017400
2.

SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

(Submitter supplied) Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
92 Samples
Download data: TXT
Series
Accession:
GSE33266
ID:
200033266
3.

Absence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge

(Submitter supplied) To further investigate the underlying mechanisms of severe acute respiratory syndrome (SARS) pathogenesis and evaluate the therapeutic efficacy of potential drugs and vaccines it is necessary to use an animal model that is highly representative of the human condition in terms of respiratory anatomy, physiology and clinical sequelae. The ferret, Mustela putorius furo, supports SARS-CoV replication and displays many of the symptoms and pathological features seen in SARS-CoV-infected humans. more...
Organism:
Mustela putorius furo; Canis lupus familiaris
Type:
Expression profiling by array
Platform:
GPL3738
38 Samples
Download data: CEL
Series
Accession:
GSE11704
ID:
200011704
4.

Cell host-response to infection with novel human coronavirus EMC predict potential antivirals and important differences with SARS-coronavirus.

(Submitter supplied) Differential expression was determined in Calu-3 cells between mock infected and infection with either Human coronavirus EMC and SARS coronavirus at different times post infection.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
32 Samples
Download data: TXT
Series
Accession:
GSE45042
ID:
200045042
5.

Gene expression profiling of patients with severe acute respiratory syndrome (SARS)

(Submitter supplied) We used cDNA microarrays to systematically analyze host responses in SARS-infected individuals from onset of symptoms to discharge from hospital or death. We modeled gene expression in 60 datasets from 40 unique patients of varied clinical evolution with emphasis on correlating innate and adaptive immune responses with discrete clinical phases of the disease. Keywords: Comparative patient class comparision, SARS patients relative to healthy controls
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4387
70 Samples
Download data: GPR
Series
Accession:
GSE5972
ID:
200005972
6.

Gene expression profiling of SARS-CoV-1/2 infected human cell lines at bulk and single-cell level

(Submitter supplied) To identify human genes and cellular pathways influencing SARS-CoV-1 and SARS-CoV-2 infection, we performed genome-wide measurements of different aspects of gene expression at the bulk and single-cell level.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL20301 GPL18573 GPL24676
203 Samples
Download data: TSV
Series
Accession:
GSE148729
ID:
200148729
7.

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation

(Submitter supplied) Background: Type I interferons (IFNs) are essential to the clearance of viral diseases, in part by initiating upregulation of IFN regulated genes (IRGs). A clear distinction between genes upregulated directly by virus and genes upregulated by secondary IFN production has not been made. Here we investigated the genes regulated by IFN-a2b compared to the genes regulated by SARS-CoV infection in ferrets. more...
Organism:
Canis lupus familiaris; Mustela putorius furo
Type:
Expression profiling by array
Platform:
GPL3738
43 Samples
Download data: CEL
Series
Accession:
GSE22581
ID:
200022581
8.

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression and cell state changes

(Submitter supplied) We performed single-cell RNA sequencing on human bronchial epithelial cells infected with SARS-CoV-2. Results revealed a detailed characterization of genes, cell types, and cell state changes asociated with SARS-CoV-2 infection in the human airway.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
4 Samples
Download data: H5AD, MTX, TSV
Series
Accession:
GSE166766
ID:
200166766
9.

SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
438 Samples
Download data: TXT
Series
Accession:
GSE47963
ID:
200047963
10.

SHAE004: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-dORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
134 Samples
Download data: TXT
Series
Accession:
GSE47962
ID:
200047962
11.

SHAE003: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-ddORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
141 Samples
Download data: TXT
Series
Accession:
GSE47961
ID:
200047961
12.

SHAE002: SARS-CoV, SARS-dORF6 and SARS-BatSRBD infection of HAE cultures.

(Submitter supplied) HAE cultures were infected with SARS-CoV, SARS-dORF6 or SARS-BatSRBD and were directly compared to A/CA/04/2009 H1N1 influenza-infected cultures. Cell samples were collected at various hours post-infection for analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
163 Samples
Download data: TXT
Series
Accession:
GSE47960
ID:
200047960
13.

SCL005: icSARS CoV Urbani or icSARS deltaORF6 infections of the 2B4 clonal derivative of Calu-3 cells - Time course

(Submitter supplied) Purpose of experiment was to compare transcriptomics of 2B4 cells (clonal derivative of Calu-3 cells) infected with either icSARS CoV or the icSARS deltaORF6 mutant.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
99 Samples
Download data: TXT
Series
Accession:
GSE33267
ID:
200033267
14.

Gene expression pattern of pulmonary CD11c+ cells from middle-aged and young mice.

(Submitter supplied) Analysis of function of CD11c+ cells from middle-aged and young mice at gene level. This experiment provided insight into the different genes that plays roles in inflammation, immune response and mainly arachidonic acid cascade that are differentiall expressed in CD11c+ cells from middle aged and young mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5879
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE71868
ID:
200071868
15.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
Download data
16.

Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses

(Submitter supplied) Two highly pathogenic human coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) have evolved proteins that can inhibit host antiviral responses, likely contributing to disease progression and high case-fatality rates. SARS-CoV-2 emerged in December 2019 to cause a global pandemic. Recent studies have shown that SARS-CoV-2 is unable to induce a robust type I interferon (IFN) response in human cells, leading to speculations about the ability of SARS-CoV-2 to inhibit innate antiviral responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
36 Samples
Download data: XLSX
Series
Accession:
GSE151513
ID:
200151513
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=5|blobid=MCID_60d51755324a11253f3e6293|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center