Similar studies for GEO DataSets (Select 200017666) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 15

Select item 2000176661.

Regulatory Role for PC-TP/StarD2 in the Metabolic Response to Peroxisome Proliferator Activated Receptor Alpha (PPARα)

(Submitter supplied) Phosphatidylcholine transfer protein (PC-TP, a.k.a StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose homeostasis. Microarray profiling of liver from fenofibrate fed wild type and Pctp-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE17666

ID:: 200017666

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000185642.

DEHP activation of PPAR(alpha) and CAR regulartory pathway in mouse liver

(Submitter supplied) Characterization of Peroxisome Proliferator-Activated Receptor alpha (PPAR(alpha)) - Independent Effects of PPAR(alpha) Activators in the Rodent Liver: Di-(2-ethylhexyl) phthalate Activates the Constitutive Activated Receptor data files in this series indicate the involvement of PPAR(alpha) and CAR regulatory pathway after DEHP treatment. Keywords: gene expression/microarray

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3748
Platform:: GPL6246
15 Samples

Download data: CEL

Series

Accession:: GSE18564

ID:: 200018564

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37483.

Peroxisome proliferator-activated receptor alpha deficiency effect on phthalate-exposed liver

Analysis of livers from peroxisome proliferator-activated receptor (PPAR) α-null animals exposed to the plasticizer di-(2-ethylhexyl) phthalate (DEHP). DEHP increases liver tumors in the absence of PPARα. Results provide insight into DEHP-induced transcriptional changes independent of PPARα.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:: GPL6246
Series:: GSE18564
15 Samples

Download data: CEL

DataSet

Accession:: GDS3748

ID:: 3748

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000148694.

Analysis of the Heat Shock Response in Mouse Liver Reveals Transcriptional Dependence on the Nuclear Receptor PPARα

(Submitter supplied) The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) regulates responses to chemical or physical stress in part by altering expression of genes involved in proteome maintenance. Many of these genes are also transcriptionally regulated by heat shock (HS) through activation by HS factor-1 (HSF1). We hypothesized that there are interactions on a genetic level between PPARα and the HS response mediated by HSF1. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE14869

ID:: 200014869

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000732995.

Global hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice fed ad libitum, fasted for 24 hours and re-fed

(Submitter supplied) If the function of the nuclear receptor PPARa is well-known during a prolongated fasting, its hepatic biological function during feeding and refeeding conditions still needs to be investigated. Moreover, in vivo data collected so far on PPARa function during fasting were obtained using the total Ppara KO transgenic mouse model. To identify genes whose expression is under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara KO (KO), wild-type (WT) and liver WT (albumin-Cre-/- Pparaflox/flox or LWT) mice under three nutritional challenges. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
52 Samples

Download data: TXT

Series

Accession:: GSE73299

ID:: 200073299

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000732986.

Global hepatic gene expression data from PPARa liver KO, PPARa liver WT, PPARaKO and WT male mice treated or not with Fenofibrate

(Submitter supplied) Fenofibrate is a specific agonist of the nuclear receptor PPARa. To identify the gene expression under the strict dependence of hepatic PPARa activity, we generated a new mouse strain of PPARa-specific deletion in hepatocyte (albumin-Cre+/- Pparaflox/flox or LKO) and we compared them to total Ppara KO (KO), wild-type (WT) and liver WT (albumin-Cre-/- Pparaflox/flox or LWT) mice. We used microarrays to detail the global programme of gene expression in liver of Ppara LKO, LWT, Ppara KO and WT male mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
34 Samples

Download data: TXT

Series

Accession:: GSE73298

ID:: 200073298

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000154947.

Human umbilical vein endothelial cells (HUVECs) treated with fenofibrate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4044
28 Samples

Download data: TXT

Series

Accession:: GSE15494

ID:: 200015494

Select item 2000154838.

The effect of fenofibrate on endothelial cells

(Submitter supplied) Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we generated microarray data from human endothelial cells treated with fenofibrate with and without siRNA-mediated knock-down of PPARa.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4044
19 Samples

Download data: TXT

Series

Accession:: GSE15483

ID:: 200015483

Select item 2000154829.

The effect of PPARa siRNA on endothelial cells treated with fenofibrate

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4044
9 Samples

Download data: TXT

Series

Accession:: GSE15482

ID:: 200015482

Select item 20010704110.

The whole genome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

(Submitter supplied) The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known about the effect of PPARα activation in human liver. The aim of the present study was to better characterize the impact of PPARα activation on gene regulation in human liver by combining transcriptomics with the use of hepatocyte humanized livers. To that end, chimeric mice containing hepatocyte humanized livers were given an oral dose of 300 mg/kg fenofibrate daily for 4 days. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platform:: GPL11532
6 Samples

Download data: CEL

Series

Accession:: GSE107041

ID:: 200107041

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005171211.

PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.

(Submitter supplied) Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown. We investigated the regulation of vanin-1, and total vanin activity, by PPARα in mice and humans. Furthermore, the function of vanin-1 in the development of hepatic steatosis in response to starvation was examined in Vnn1 deficient mice, and in rats treated with an inhibitor of vanin activity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4872
Platform:: GPL11533
16 Samples

Download data: CEL

Series

Accession:: GSE51712

ID:: 200051712

Select item 487212.

Fasting effect on vanin-1 depleted liver

Analysis of liver from vanin-1 KOs fasted for 24 hrs. Vanin-1 is highly expressed in liver compared to other tissues. In the fasted state, liver switches to fatty acid oxidation and glucose production. Results provide insight into the role of vanin-1 in hepatic lipid metabolism during starvation.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL11533
Series:: GSE51712
16 Samples

Download data: CEL

DataSet

Accession:: GDS4872

ID:: 4872

Select item 20001786513.

Transcriptional profiling reveals divergent roles of PPARa and PPARß/d in regulation of gene expression in mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL7440 GPL6246
34 Samples

Download data: CEL

Series

Accession:: GSE17865

ID:: 200017865

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001786414.

mRNA profiling reveals divergent roles of PPARa and PPARß/d in regulating mouse liver gene expression (PPARb/d samples)

(Submitter supplied) Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to better elucidate the function of PPARß/d in liver by comparing the effect of PPARa and PPARß/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed state, the number of genes altered by PPARa and PPARß/d deletion was similar, whereas in fasted state the effect of PPARa deletion was much more pronounced, consistent with the pattern of gene expression of PPARa and PPARß/d. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
16 Samples

Download data: CEL

Series

Accession:: GSE17864

ID:: 200017864

Select item 20022487715.

Whole body Knockout of PC-TP (Pctp-/-), Hepatic whole RNAseq comparing Wild Type (WT) and knock out mic (KO) as well as Chow Fed and Methionine and choline depleted (MCD) fed mice.

(Submitter supplied) Previous studies have used this model to show that PC-TP has a protective effect when challenged with a methionine and choline depleted diet, known to induce NAFLD. We performed transcription factor binding experiments and show that PPARs are dysregulated in the contect of PC-TP depletion We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 Mice for WT and KO fed either normal chow or methionine and choline depleted chow.