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Links from GEO DataSets

Items: 11

1.

Prkar1a haploinsufficiency leads to an overall increase in tumors caused by other genetic defects or chemical induction

(Submitter supplied) [original title] Prkar1a haploinsufficiency in mice leads to an overall increase in tumors caused by other genetic defects or chemical induction We investigated the Prkar1a+/- mice when bred within the Rb1+/- or Trp53+/- genetic backgrounds, or treated with a 2-step skin carcinogenesis protocol. Prkar1a+/-Trp53+/- mice developed more bone sarcomas than Trp53+/- mice (p<0.05) and Prkar1a+/-Rb1+/- mice grew more and larger pituitary and thyroid tumors than Rb1+/- mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
23 Samples
Download data: TXT
Series
Accession:
GSE19576
ID:
200019576
2.

Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations

(Submitter supplied) PRKAR1A inactivating mutations are responsible for primary pigmented nodular adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing adenomas (CPA). The whole-genome expression profile (WGEP) of normal (pooled) adrenals, PRKAR1A- (3) and GNAS-mutant (3) was studied.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6255
9 Samples
Download data: TXT
Series
Accession:
GSE33694
ID:
200033694
3.

Spontaneous SCC induced by the somatic inactivation of Rb1 and Trp53 tumor suppressors in mouse stratified epithelia

(Submitter supplied) The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
8 Samples
Download data: CEL
Series
Accession:
GSE9144
ID:
200009144
4.

Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone

(Submitter supplied) We investigated the Prkar1a+/- mice when bred with Prkaca+/- genetic backgrounds. Prkar1a+/-Prkaca+/- mice not only continued to develop bone lesions but also demonstrated a significant increase in both the number and the severity of the lesions, as well as a reduction in the age of first appearance of any bone abnormality. Histological analysis of bone from Prkar1a+/-Prkaca+/- mice showed that lesions had similarity to tumors from humans with CNC and some resemblance (but also differences) from humans and mice with fibrous dysplasia (FD). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
13 Samples
Download data: TXT
Series
Accession:
GSE20984
ID:
200020984
5.

Wild Type Tumor Repressor Protein 53 (TRP53) Promotes Ovarian Cancer Cell survival

(Submitter supplied) Loss of Pten in the KrasG12D;Amhr2-Cre mutant mice leads to the transformation of ovarian surface epithelial (OSE) cells and rapid development of low-grade, invasive serous adenocarcinomas. Tumors occur with 100% penetrance and express elevated expression of wild type tumor repressor protein 53 (TRP53). To test the functions of TRP53 in the Pten;Kras (Trp53+) mice, we disrupted the Trp53 gene yielding Pten;Kras(Trp53-) mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE34882
ID:
200034882
6.

Mesenchymal tumors can derive from pericytes.

(Submitter supplied) We demonstrated that deletion of the p53 tumor suppressor gene in NG2 expressing cells resulted in the development of bone and soft tissue sarcomas that closely resemble human tumors. To determine gene expression differences between NG2 expressing pericytes lacking p53 and sarcomas that arose from deletion of p53 in NG2 expressing cells, RNA sequencing analysis was implemented.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: TXT
Series
Accession:
GSE63679
ID:
200063679
7.

Transcriptome analysis of a novel mouse model of osteosarcoma and soft tissue sarcoma

(Submitter supplied) Analysis of differential gene expression between mouse sarcoma and normal tissue
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE63631
ID:
200063631
8.

Gene expression profiling of mouse B cell progenitors

(Submitter supplied) Gene expression profiling was performed of Pax5 wild type bone marrow subsets from common lymphoid progenitors through to Hardy stage F cells. These cells were obtained by flow sorting of bone marrow.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
41 Samples
Download data: CEL
Series
Accession:
GSE38463
ID:
200038463
9.

The Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia

(Submitter supplied) The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptional profile and submicroscopic genetic alterations. Near haploid cases with 24-31 chromosomes frequently harbor alterations targeting receptor tyrosine kinase- and Ras signaling (71%) and IKZF3 (AIOLOS; 13%). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13158
118 Samples
Download data: CEL
Series
Accession:
GSE27237
ID:
200027237
10.

Gene expression profile of tumors developed in the spleen of p53-haploinsufficient mice

(Submitter supplied) We aimed to ivestigate the effects of LSD1 on the gene expression program of p53-haploinsufficient mice to understand the molecular mechanisms underlying the development of lymphoid malignancies.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21810
3 Samples
Download data: TXT
Series
Accession:
GSE95119
ID:
200095119
11.

Effects of TRP53 upregulation by nutlin 3a on the transcriptome of interstitial cell of Cajal (ICC) stem cells

(Submitter supplied) Interstitial cells of Cajal (ICC) are electrical pacemakers and mediators of neuromuscular neurotransmission in the gastrointestinal tract. Studies in organotypic cultures of intact gastric muscular wall tissues identified Kit(low)Cd44(+)Cd34(+)Insr(+)Igf1r(+) cells as local ICC progenitors (Lorincz et al., Gastroenterology 2008;134:1083-1093). Subsequently, conditionally immortalized Kit(low)Cd34(+) cells were isolated by immunomagnetic and fluorescent cell sorting and serial cloning from the gastric muscular wall of homozygous, 14-day-old H-2Kb-tsA58 and 7-day-old wild-type C57BL/6J mice and shown to share other phenotypic characteristics with in-situ ICC precursors (Bardsley et al., Gastroenterology 2010;139:942-952). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
6 Samples
Download data: TXT
Series
Accession:
GSE139539
ID:
200139539
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