Similar studies for GEO DataSets (Select 200019939) - GEO DataSets

Select item 2000199391.

Effect of valproic acid on hematopoiesis: A functional profiling and cell phenotyping approach

(Submitter supplied) Analysis of the effects of valproic acid (VPA) on chronic myelogenous leukemia K562 cells. This study attempts to elucidate the effects of VPA on cell homeostasis and hematopoietic differentiation pathways in this cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
15 Samples

Download data: GPR

Series

Accession:: GSE19939

ID:: 200019939

Select item 2000312832.

Expression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)

(Submitter supplied) Histone deacetylase (HDAC) inhibitors are widely utilized in hematopoietic malignance therapy; nevertheless, little is currently known concerning their effects on normal myelopoiesis. In order to investigate a putative interference of HDAC inhibitors in myeloid commitment of hematopoietic stem/progenitor cells (HSPCs) we treated CD34+ cells with valproic acid (VPA). Moreover, we investigate changes in gene expression induced by VPA treatment on HSPCs, by means of microarray analysis in VPA treated and untreated (CTR) CD34+ cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE31283

ID:: 200031283

Select item 2000410203.

Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function

(Submitter supplied) Expression profiles of LSK cells stimulated for 24h in the presence or in the absence of of valproic acid (VPA) The molecular process that underlies the biological effects of valproic acid (VPA), a widely used histone deacetylase inhibitor, on HSPCs was investigated by studying the early-response genes of VPA. Genome-wide gene expression studies revealed overrepresentation of genes involved in glutathione metabolism, receptor and signal transducer activity and changes in the HSPCs surface profile following short, 24h VPA treatment. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
6 Samples

Download data: TXT

Series

Accession:: GSE41020

ID:: 200041020

Select item 2000598034.

Epigenetic and molecular signatures of cord blood CD34(+) cells treated with histone deacetylase inhibitors

(Submitter supplied) Gene expression profiling of primary cord blood hematopoietic stem cell (day 0, CD34+ cells), enriched control (untreated), Scriptaid and Valproic acid expanded CD34+ cells after a week in culture. Cord blood CD34+ cells were processed individually and equal number of PC and reisolated CD34+ cells from 3-4 samples were pooled after expansion to avoid sample variations.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE59803

ID:: 200059803

Select item 2000352925.

mRNA profiles of four developmentally related hematopoietic cell types (LSK, L-S-K+, Gr1+ and Ter119+) isolated from the BM of B6 and D2 mice

(Submitter supplied) The combination of valproic acid and lithium delays hematopoietic stem\progenitor differentiation

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
24 Samples

Download data: TXT

Series

Accession:: GSE35292

ID:: 200035292

Select item 2000352916.

Expression profiles of 7-day cultured HSPCs in the presence or absence of valproic acid and/or lithium

(Submitter supplied) Two small molecules, valproic acid (VPA) and lithium (Li), were tested to inhibit differentiation of hematopoietic stem/progenitor (HSPC) cells in culture. HSPCs exposed to VPA and Li during differentiation-inducing culture preserved an immature cell phenotype, provided radioprotection to lethally irradiated recipients and enhanced in vivo repopulating potential. Furthermore, VPA and Li synergistically preserved expression of stem cell-related genes and repressed genes involved in differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
12 Samples

Download data: TXT

Series

Accession:: GSE35291

ID:: 200035291

Select item 2000340887.

The combination of valproic acid and lithium prevents hematopoietic stem/progenitor cell differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6885 GPL6887
36 Samples

Download data

Series

Accession:: GSE34088

ID:: 200034088

Select item 2000862538.

Bach Factors Operate Erythro-Myeloid Differentiation by Responding to Infection

(Submitter supplied) Hematopoietic cell differentiation should be tightly regulated in accordance with environmental changes to keep homeostasis. Infection is one of the conditions that induce myelopoiesis to exclude pathogens and repress erythropoiesis, which might be beneficial for the restriction of nutritional iron for pathogens. While several transcription factors (TFs), including C/EBP family and Gata1, play central roles in erythro-myeloid differentiation, the precise mechanism which controls the differentiation for the adaptation to infection remains obscure. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
6 Samples

Download data: TXT

Series

Accession:: GSE86253

ID:: 200086253

Select item 2000796979.

Investigation of Bach2 function by regulating inflammatory response and heme-iron homeostasis of bone marrow macrophage.

(Submitter supplied) Macrophages are central in regulating iron homeostasis. Transcription repressor Bach2 regulates by heme. Here we investigated the relationship between heme-regulated Bach2 and macrophage in bone marrow. We identified RFP-positive and negative macrophage were in bone marrow. We found that RFP-positive macrophage related with iron-heme homeostasis maintenance and RPF-negative population related with immune response. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
6 Samples

Download data: TXT

Series

Accession:: GSE79697

ID:: 200079697

Select item 20018568510.

Small RNA analysis of human erythropoiesis

(Submitter supplied) Small RNAs including microRNAs play a critical role at different stages of haematopoiesis. The study was designed to profile miRNA expression during human erythropoiesis.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE185685

ID:: 200185685

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001280311.

Gene expression in human myeloid cells

(Submitter supplied) Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
20 Samples

Download data: CEL

Series

Accession:: GSE12803

ID:: 200012803

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010835512.

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data

Series

Accession:: GSE108355

ID:: 200108355

PubMed Full text in PMC Similar studies

Select item 20010835413.

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis [clonality]

(Submitter supplied) Definitive hematopoietic cells arise from hemogenic endothelium during mid-gestation, indicating a direct link between blood and the endothelial-lined vessels. We sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here we demonstrate that transposon mutagenesis targeting endothelial cells in mice promotes the development of hematopoietic pathologies that are both myeloid and lymphoid in nature. more...