GEO DataSets

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

35 Samples

Download data: CEL, CHP

(Submitter supplied) Analysis of human dopamine (DA) from postmortem brains of 8 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1352

17 Samples

Download data: CEL

(Submitter supplied) Analysis of substantia nigra from postmortem brains of 4 patients with Parkinson’s disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

8 Samples

Download data: CEL

(Submitter supplied) Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

93 Samples

Download data: CEL, CHP

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

29 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL6947

69 Samples

Download data: CEL

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

29 Samples

Download data: CEL, CHP

(Submitter supplied) Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease. Analysis of substantia nigrae from postmortem brains of 6 patients with Parkinson's disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

11 Samples

Download data: CEL

(Submitter supplied) Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease. Examination of substantia nigra from postmortem brains of 8 patients with Parkinson's disease (PD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

17 Samples

Download data: CEL

(Submitter supplied) Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson’s disease. Snap-frozen human substantia nigras (SNs) of 16 individuals with a clinicopathological diagnosis of incidental Lewy body (ILB) disease with Lewy bodies detected in the brainstem nuclei of locus coeruleus and substantia nigra, but generally not in higher cortical regions consistent with Braak stage 3 criteria for Parkinson's disease (PD), and 17 age-, sex-, postmortem interval-, and RNA integrity number-matched controls, who were clinicopathologically within normal limits for age collected under the rapid-autopsy program of Sun Health Research Institute or by the Harvard Brain Tissue Resource Center at McLean Hospital, were used for gene expression analyses in stage 2. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

33 Samples

Download data: TXT

(Submitter supplied) Genome-wide transcriptome analysis of expression changes in EBV transformed cell lines from the Coriell Cell Repository in Parkinson and Control subjects.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

16 Samples

Download data: CEL, CHP

(Submitter supplied) Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

20 Samples

Download data: CEL, CHP

(Submitter supplied) Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

18 Samples

Download data: CEL, CHP

(Submitter supplied) Parkinson disease (PD) is characterized by extensive loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A strong association has been reported between PD and exposure to mitochondrial toxins such as the environmental pesticides paraquat, maneb, and rotenone. Here, using a robust, patient-derived, stem cell model of PD that allows comparison of -synuclein ( -syn) mutant cells and isogeneic mutation-corrected controls, we identify mitochondrial toxin-induced perturbations specific to A53T -syn mutant A9-DA neurons (hNs). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

12 Samples

Download data: TXT

(Submitter supplied) We report RNA sequencing results of human substantia nigra and putamen samples from Parkinson's disease patients and controls. Each substantia nigra sample is the result of pooling brain tissue from two individuals with the same , while each putamen sample is the result of pooling brain tissue from three individuals. We found 354 differentially expressed genes (DEGs) in the SN of PD patients compared to age-matched controls, while we observed 261 DEGs in the putamen samples. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

16 Samples

Download data: TXT

(Submitter supplied) We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary along different anatomical regions in patients and controls. The comparative transcriptional networks analyses indicate that the main hubs in PD networks are related to ubquitin/proteasome, oxidative stress, neuroprotection, neurogenesis and PD associated proteins.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

41 Samples

Download data: TXT

(Submitter supplied) Affymetrix HG_U133 array sets (A and B chips) were used to determine the whole genome transcription profile of clinically documented and neuropathologically confirmed cases of sporadic Parkinson's disease as well as controls. Keywords: disease-state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS3128 GDS3129

Platforms:

GPL96 GPL97

94 Samples

Download data: CEL

Analysis of medial and lateral substantia nigras (SNs) from post-mortem brain samples obtained from individuals with sporadic Parkinson's disease (PD). The SN exhibits extensive tissue damage in PD. Results provide insight into the pathogenesis of PD.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 23 individual, 3 tissue sets

Platform:

GPL97

Series:

GSE8397

47 Samples

Download data: CEL

Analysis of medial and lateral substantia nigras (SNs) from post-mortem brain samples obtained from individuals with sporadic Parkinson's disease (PD). The SN exhibits extensive tissue damage in PD. Results provide insight into the pathogenesis of PD.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 23 individual, 3 tissue sets

Platform:

GPL96

Series:

GSE8397

47 Samples

Download data: CEL

(Submitter supplied) We performed a whole-transcriptome analysis of the peripheral blood of untreated patients with stage 1 PD (Hoehn–Yahr scale).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5646

Platform:

GPL10558

10 Samples

Download data: TXT