GEO DataSets

(Submitter supplied) In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tissues of Car6-/- mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT

(Submitter supplied) Background Carbonic anhydrases (CAs) are a family of enzymes that regulate pH homeostasis in various tissues. CA IX is an exceptional member of this family because in addition to the basic CA function, it has been implicated in several other physiological and pathological processes. Functions suggested for CA IX include roles in cell adhesion and malignant cell invasion. In addition, CA IX likely regulates cell proliferation and differentiation, which was demonstrated in Car9‾/‾ mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

12 Samples

Download data: TXT

(Submitter supplied) Hfe disruption in the mouse leads to experimental hemochromatosis by a mechanism which remains elusive. Evidence for at least five modifier genes has been obtained. These account for the higher iron load of Hfe-deficient D2 mice compared to B6 mice. Gene expression profling was used to clarify the mechanism of Hfe action and to identify potential modifier genes. Keywords: response to genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

24 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Series includes pooled (n = 5 mice per biological replicate) samples from lacrimal, meibomian, and submandibular glands of male palcebo- and testosterone-treated BALB/c mice. All experiments were run in triplicate (pooled biological replicates) on CodeLink Mouse Uniset I Microarrays. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1361

Platform:

GPL1310

18 Samples

Download data

Analysis of meibomian glands from orchiectomized BALB/c adults treated with testosterone for 14 days. Androgen deficiency associated with glandular dysfunction and evaporative dry eye. Lacrimal and submandibular glands included. Results suggest pathways regulated by androgens in meibomian glands.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 tissue sets

Platform:

GPL1310

Series:

GSE1582

18 Samples

Download data

(Submitter supplied) Our objective was to determine the nature and extent of androgen regulation of gene expression in the female lacrimal, meibomian,and submandibular glands, and to explore the degree to which this control is the same as in male glands. Keywords: Hormone treatment

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1832 GDS1833

4 related Platforms

36 Samples

Download data: CEL, TXT

Expression profiling of submandibular glands from BALB/c females. Females ovariectomized at 8 weeks and allowed to recover from surgery for 10 days prior to testosterone treatment. Results compared to the response of male glands to testosterone.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL81

Series:

GSE3995

6 Samples

Download data

Expression profiling of lacrimal, meibomian, and submandibular glands from BALB/c females. Females ovariectomized at 8 weeks and allowed to recover from surgery for 10 days prior to testosterone treatment. Results compared to the response of male glands to testosterone.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 tissue sets

Platform:

GPL1310

Series:

GSE3995

18 Samples

Download data

(Submitter supplied) Iron is an essential trace element whose absorption is usually tightly regulated in the duodenum. HFE-related hereditary hemochromatosis (HH) is characterized by abnormally low expression of the iron-regulatory hormone, hepcidin, which results in increased iron absorption. The liver is crucial for iron homeostasis as it is the main production site of hepcidin. The aim of this study was to explore and compare the genome-wide transcriptome response to Hfe deficiency and dietary iron overload in murine liver and duodenum.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

19 Samples

Download data: TXT

(Submitter supplied) Although immune mechanisms have been described for Peyer’s patch function, in discriminating food nutrients and commensal microflora from pathogenic challenge, an understanding of gene expression patterns associated with normal intestinal homeostasis is lacking. The effects of commensal bacterial colonization on global gene expression in the small intestine of germ-free mice have been described (1, 2). more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL1624

6 Samples

Download data: TIFF

(Submitter supplied) Hyposalivation is a complication of hypertension. Although the lncRNA have recently been identified to play a role in the pathogenesis of hypertension, the specific effects of lncRNAs on hyposalivation caused by hypertension remain unclear. The aim of the current study was to construct and systematically analyze the lncRNA-miRNA-mRNA network and reveal its potential roles in hyposalivation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL26961

10 Samples

Download data: TXT

(Submitter supplied) Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing reversible interconversion between CO2 and bicarbonate (HCO3-), but also important CO2-signaling modulators. more...

Organism:

Cryptococcus neoformans var. neoformans JEC21; Cryptococcus neoformans var. grubii H99

Type:

Expression profiling by array

Platform:

GPL8638

17 Samples

Download data: GPR

(Submitter supplied) Three groups of male +b and bb rats were obtained (ages between 6 and 14 months) and intestinal scrapes were taken. Tissues was combined from 3 rats per group and processed for gene chip analysis. Keywords: Belgrade, iron deficiency, intestine, microarray

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) sequential changes in gene expression profiles in the gastric adenoma-carcinoma sequence by analyzing eight patient-matched gastric normal mucosa, adenomas and carcinomas.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10982

26 Samples

Download data: GPR

(Submitter supplied) We used microarrays to detail the global programme of gene expression of the mouse colon responses to Salmonella (SL1344 and SB1117) infection at the early phase (8 hours) and the late phase (4 days). We specifically examined the the differentillay gene expression profiles in mouse colon when it responded to pathogenic Salmonella stain SL1344 (with AvrA expression) or SB1117 (without AvrA expression).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

18 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Brown and white adipose tissues (BAT and WAT) play critical roles in controlling energy homeostasis and in the development of obesity and diabetes. Fsp27 is expressed in both BAT and WAT and promotes lipid storage and the development of obesity and diabetes. In addition, Fsp27-deficient white adipocytes acquired certain BAT-like properties including reduced lipid droplet size and increased mitochondrial activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3768

Platform:

GPL339

4 Samples

Download data: CEL, CHP

Analysis of gonadal white adipose tissue (WAT) from Fat-Specific protein 27 (FSP27)-null males. FSP27-null WATs have reduced lipid storage, smaller lipid droplets, and increased mitochondrial activity. Results provide insight into molecular mechanisms by which FSP27 controls lipid storage in WAT.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE22693

4 Samples

Download data: CEL, CHP

(Submitter supplied) Ablation of the mouse gene for Onecut-2 was reported previously, but characterization of the resulting knockout mice was focused on in utero development, principally embryonic development of liver and pancreas. Here, we examine postnatal development of these Onecut-2 knockout mice, especially the critical period prior to weaning. Microarray technology was used to determine the effect of Onecut-2 ablation on gene expression in duodenum, whose epithelium has among the highest levels of Onecut-2. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL