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Links from GEO DataSets

Items: 20

1.

Hepatocyte-nuclear-factor-4a promotes gut neoplasia in mice and protects against the production of reactive oxygen species

(Submitter supplied) Hepatocyte-nuclear-factor-4α (Hnf4α) is a transcription factor that controls epithelial cell polarity and maturation during embryogenesis. Hnf4α conditional deletion during post-natal development results in minor consequences on intestinal epithelium integrity but promotes activation of the Wnt/β-catenin pathway. Here we show that Hnf4α does not act as a tumor suppressor gene but is crucial to promote gut tumorigenesis in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE20968
ID:
200020968
2.

Comparison of HNF4 null to control colons

(Submitter supplied) Background and Aims: HNF4a is a nuclear hormone receptor transcription factor that has been shown to be required for hepatocyte differentiation and development of the liver. It has also been implicated in regulating expression of genes that act in the epithelium of the lower gastrointestinal tract. This implied that HNF4a might be required for development of the gut. Methods: We generated mouse embryos in which HNF4a was ablated in the epithelial cells of the fetal colon using Cre-loxP technology. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1507
Platform:
GPL339
5 Samples
Download data: CEL
Series
Accession:
GSE3116
ID:
200003116
3.
Full record GDS1507

Transcription factor HNF4 null mutation effect on fetal colon

Analysis of epithelial cells from colon lacking hepatocyte nuclear factor 4 (HNF4) from embryos at E18.5. HNF4 encodes a nuclear hormone receptor transcription factor required for hepatocyte differentiation and liver development. Results provide insight into the role of HNF4 in colon development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE3116
5 Samples
Download data: CEL
4.

Expression data from mouse intestine: BALB/c MTHFR+/+ on control diet vs BALB/c MTHFR+/- on folate deficient diet

(Submitter supplied) Previous studies in our laboratory have shown that low folate diet (control diet with 2mg folate/kg, low folate diet with 0.3mg folate/kg) can induce intestinal tumors in BALB/c mice. We used microarrays to compare MTHFR+/+ BALB/c mice fed control diet and MTHFR+/- BALB/c mice fed low folate diet.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5377
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE34011
ID:
200034011
5.
Full record GDS5377

Folate deficiency effect on methylenetetrahydrofolate reductase MTHFR+/- intestinal neoplasia model: duodenum

Analysis of intestine from MTHFR+/- BALB/c mice fed a low folate diet (0.3mg/kg) for 1 yr. The MTHFR C677T polymorphism is associated with risk for colorectal cancer. Results provide insight into mechanisms underlying the impact of folate and MTHFR deficiency on tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL6246
Series:
GSE34011
8 Samples
Download data: CEL
DataSet
Accession:
GDS5377
ID:
5377
6.

Expression profile analysis of inflammatory response regulated by hepatocyte nuclear factor 4α

(Submitter supplied) To obtain a genomic view of hepatocyte nuclear factor-4α (HNF-4α) in the regulation of the inflammatory response, microarray analysis was used to probe the expression profile of an inflammatory response induced by cytokines in a model of knock-down HNF-4α HepG2 cells. The results indicate an extensive role for HNF-4α plays in the regulation of a large number of the liver-specific genes. Majority of genes (71%) affected by cytokine treatment are also affected by HNF-4α knock-down. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
16 Samples
Download data: CEL
Series
Accession:
GSE15991
ID:
200015991
7.

Role of HNF4alpha in the adult colon

(Submitter supplied) Background & Aims: HNF4α is an important transcriptional regulator of hepatocyte and pancreatic function. Hnf4α deletion is embryonically lethal with severe defects in visceral endoderm formation, liver maturation and colon development. However, the precise role of this transcription factor in maintaining homeostasis of the adult intestine remains unclear. Herein, we aimed to elucidate the adult intestinal functions of Hnf4α. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5284
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE11759
ID:
200011759
8.
Full record GDS5284

Hepatocyte nuclear factor 4 alpha deficiency effect on the colon

Analysis of hepatocyte nuclear factor 4 alpha (HNF4-alpha) deficient colons of 1 year old animals. HNF4-alpha is a transcription factor. Deletion of HNF4-alpha confined to the epithelial colon. Results provide insight into the role of HNF4-alpha in maintaining intestinal inflammatory homeostasis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE11759
6 Samples
Download data: CEL
9.

Non-tumor/tumor intestinal tissue of control or intestine-specific HAI-1 deficient Apc(Min/+) mice

(Submitter supplied) To analyse roles of HAI-1/Spint1 in intestinal tumorigenesis, we examined the effect of intestine-specific deletion of Spint1 gene on Apc(Min/+) mice. The loss of Hai-1/Spint1 significantly accelerated tumor formation in ApcMin/+ mice and shortened their survival periods. Mouse small intestine tumor tissue or background mucosa lacking macroscopically visible tumors were proceeded to RNA extraction and hybridization on microarrays (Affymetrix Mouse Genome 430 2.0 Array).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE40856
ID:
200040856
10.

Epithelium transition profile

(Submitter supplied) Transcriptional Profiling of the Transition from Normal Intestinal Epithelia to Adenomas and Carcinomas in the APC(Min/+) Mouse. Samples used in analysis: * GSM6191-GSM6196 (WT): Ilea epithelial cells from C57/BL6 wild-type samples * GSM6197-GSM6201 (Adenoma): Epithelial cells from crypts of adenomas of APC(Min/+) mice * GSM6202-GSM6206 (Carcinoma): Epithelial cells from crypts of carcinomas of APC(Min/+) mice Using a PixCell IIe instrument (Arcturus), ~30,000 laser firings per sample were used to collect cells of interest. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS389
Platform:
GPL81
16 Samples
Download data
Series
Accession:
GSE422
ID:
200000422
11.
Full record GDS389

Colon cancer

Examination of transition from normal intestinal epithelia to adenomas and carcinomas in the multiple intestinal neoplasia adenomatous polyposis coli mutant mouse, APC(Min/+).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state, 2 strain sets
Platform:
GPL81
Series:
GSE422
16 Samples
Download data
DataSet
Accession:
GDS389
ID:
389
12.

Sex-dependent and HNF4alpha-dependent Mouse Liver Gene Expression

(Submitter supplied) A series of dual-channel gene expression profiles obtained using Rosetta/Agilent Whole Mouse Genome oligonucleotide microarrays, 4 x 44K format, was used to identify sex-dependent and HNF4alpha-dependent differences in gene expression in adult mouse liver. This series is comprised of four sex-genotype combinations: adult male wild-type liver (M-WT), adult female wild-type liver (F-WT), adult male liver-specific HNF4alpha knockout liver (M-KO) and adult female liver-specific HNF4alpha knockout liver (F-KO). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
16 Samples
Download data: XLS
Series
Accession:
GSE10390
ID:
200010390
13.

Expression data from Caco-2 cells expressing TLR4 and associated mutants

(Submitter supplied) Common missense mutations (D299G, T399I) have been recently identified in the human TLR4 gene. The aim of this study was to determine how TLR4 and associated mutants affect gene expression in Caco-2 cells. We used microarrays to asses gene expression profiles in Caco-2 stably overexpressing TLR4-WT, TLR4-D299G, TLR4-T399I or untransfected.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
12 Samples
Download data: CEL
Series
Accession:
GSE26226
ID:
200026226
14.

HNF4α is a therapeutic target that links AMPK to WNT signaling in early-stage gastric cancer

(Submitter supplied) Background Worldwide, gastric cancer is the fourth most common malignancy and the most common cancer in East Asia. Development of targeted therapies for this disease has focused on a few known oncogenes but has had limited effects. Objective To determine oncogenic mechanisms and novel therapeutic targets specific for gastric cancer by identifying commonly dys-regulated genes from the tumors of both Asian-Pacific and Caucasian patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13393
44 Samples
Download data: TXT
Series
Accession:
GSE63288
ID:
200063288
15.

AMPKα Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric Cancer

(Submitter supplied) Gastric cancer is the most common cancer in Asia and most developing countries. To identify the molecular underpinnings of gastric cancer in the Asian population, we applied an RNA-sequencing approach to gastric tumor and noncancerous specimens to quantitatively characterize the entire transcriptome of gastric cancer (including mRNAs and microRNAs). A multi-layer analysis was then developed to identify multiple types of transcriptional aberrations associated with different stages of gastric cancer, including differentially expressed mRNAs, recurrent somatic mutations and key differentially expressed microRNAs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL9442
55 Samples
Download data: XLS
Series
Accession:
GSE36968
ID:
200036968
16.

H3K27ac profiling in control and DSS-treated colonic epithelium

(Submitter supplied) We determined changes in enhancer chromatin that occur during colonic inflammation, found that dynamic chromatin regions are enriched for HNF4A binding motirfs, and then measured HNF4A binidng by ChIP-seq in each condition.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT, WIG
Series
Accession:
GSE52426
ID:
200052426
17.

Gene expression data from livers of 3-month-old HNF4alpha knockout mice

(Submitter supplied) HNF4alpha is a master regulator of hepatic differentiation. In this study, HNF4alpha was deleted in adult mice using a Cre-LoxP system where Cre recombinase was delivered using an AAV8 virus.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE35782
ID:
200035782
18.

PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
30 Samples
Download data
Series
Accession:
GSE61643
ID:
200061643
19.

Genome-wide analysis expression of ileum tumor samples from FVBN/APCmin and iPGC-1β/APCmin

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in intestinal tumors from APCmin mice overexpressing PGC-1β specifically in the intestine.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
12 Samples
Download data: TXT
Series
Accession:
GSE61642
ID:
200061642
20.

Genome-wide analysis expression of ileum samples from wild-type and iPGC-1β

(Submitter supplied) Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from transgenic mice overexpressing PGC-1β specifically in the intestine.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
10 Samples
Download data: TXT
Series
Accession:
GSE61641
ID:
200061641
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