GEO DataSets

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Rattus norvegicus; Microtus fortis

Type:

Expression profiling by array

Platform:

GPL10390

4 Samples

Download data: TXT

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Mus musculus; Rattus norvegicus; Microtus fortis

Type:

Expression profiling by array

Platforms:

GPL10390 GPL10389

6 Samples

Download data: TXT

(Submitter supplied) More than 40 kinds of mammals in China are known to be naturally infected with Schistosoma japonicum (S. japonicum); Microtus fortis (M. fortis), a species of vole, is the only mammal in which the schistosomes cannot mature or cause significant pathogenic changes. In the current study, we compared the differences in pathology by Hematoxylin-eosin staining and in changes in the T cell subsets with flow cytometry as well as gene expression using genome oligonucleotide microarrays in the lung and liver, before challenge and 10 days post-infection with schistosomes in a S. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10389

2 Samples

Download data: TXT

(Submitter supplied) Microtus fortis (M. fortis) is the only mammal in which the growth, development and maturation of schistosomes (Schistosoma japonicum) is prevented, resulting in the failure of the parasite to mature and complete its life cycle. MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs, has been found to introduce a whole new layer of gene regulation in eukaryotes. The anti-schistosomiasis mechanosm of M. more...

Organism:

Cricetulus griseus; Mus musculus; Rattus norvegicus; Microtus fortis

Type:

Non-coding RNA profiling by array

Platform:

GPL15710

18 Samples

Download data: TXT

(Submitter supplied) More than 40 species of mammal have been reported to be infected naturally with Schistosoma japonicum (Chinese mainland strain) in China. The reed vole, Microtus fortis, is the only known mammalian host in which the schistosomes are unable to mature and cause significant pathogenic changes. Gene expression profiling of the 10 day old schistosomula was performed.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

4 Samples

Download data: TXT

(Submitter supplied) Determining the molecular events induced in the spleen during schistosome infection is an essential step in better understanding the immunopathogenesis of schistosomiasis and the mechanisms by which schistosomes modulate the host immune response. The present study defines the transcriptional and cellular events occurring in the murine spleen during the progression of Schistosoma japonicum infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6481

8 Samples

Download data: TXT

(Submitter supplied) Schistosomiasis continues to be an important cause of parasitic morbidity and mortality world-wide. Determining the molecular mechanisms regulating the development of granulomas and fibrosis will be essential for understanding how schistosome antigens interact with the host environment. We report here the first whole genome microarray analysis of the murine liver during the progression of Schistosoma japonicum egg-induced granuloma formation and hepatic fibrosis. more...

Organism:

Mus musculus; Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL6105

10 Samples

Download data: TXT

(Submitter supplied) The severity of schistosome egg-induced hepatic granulomatous pathology depends markedly on the nature of the mammalian host immune response. The local cellular and molecular mechanisms that co-ordinate hepatic granuloma formation during schistosome infection are still poorly understood. We used a combination of laser microdissection microscopy and microarray analysis to further our understanding of fibrogenesis and granuloma formation in C57BL/6 mice infected with Schistosoma japonicum. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: TXT

(Submitter supplied) Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL10192

4 Samples

Download data: PAIR

(Submitter supplied) The pathological outcomes of schistosomiasis are largely dependent on the molecular and cellular mechanisms of the host immune response. In this study, we demonstrate the variation of host gene expression which underlies the contrasting hepatic pathology observed between two inbred mouse strains following schistosome infection. Whole genome microarray analysis was employed in conjunction with histological and immunohistochemical analysis to define and compare the hepatic gene expression profiles and cellular composition associated with the hepatopathology observed in BALB/c and CBA mice during an active Schistosoma japonicum infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) The microarray analysis of gene expression difference between cattle,buffalo and goat,provide us a profiling as a new platform to discover the difference between their compatibility

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL10987

9 Samples

Download data: TXT

(Submitter supplied) The microarray analysis of gene expression difference between cattle and buffalo, provide us a profiling as a new platform to discover the difference between their compatibility with schistosoma japonicum.

Organism:

Bubalus bubalis; Bos taurus

Type:

Expression profiling by array

Platform:

GPL11648

12 Samples

Download data: TXT