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Links from GEO DataSets

Items: 20

1.

Expression data from white adipose tissue of Perilipin A transgenic mice

(Submitter supplied) Perilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Adipocyte specific overexpression of PeriA caused resistance to diet-induced obesity and resulted in improved insulin sensitivity. In order to better understand the biological basis for this observed phenotype we performed DNA microarray analysis on white adipose tissue (WAT) from PeriA transgenic (Tg) and control wildtype (WT) mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE21754
ID:
200021754
2.

Brown versus white tissue adipose selective genes

(Submitter supplied) The aim of this study was to identify genes expressed selectively in brown adipose tissue as compared to white adipose tissue from the same animals. This analysis provides a gene set that is brown and white adipose selective. Keywords: tissue comparison from mice
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2813
Platform:
GPL1261
6 Samples
Download data: CEL, CHP, DCP, TXT
Series
Accession:
GSE8044
ID:
200008044
3.
Full record GDS2813

Brown and white adipose tissues

Comparison of brown and white adipose tissues. Brown fat cells are specialized to dissipate energy and can counteract obesity. Results provide insight into the molecular mechanisms controlling brown fat cell determination.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL1261
Series:
GSE8044
6 Samples
Download data: CEL, CHP, DCP, TXT
4.

Expression data from human adipose tissue using an expanded patient cohort

(Submitter supplied) Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expression signature of adipose tissue in a body mass index (BMI)-matched obese cohort of patients that are either insulin sensitive or insulin resistant.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3781
Platform:
GPL570
39 Samples
Download data: CEL
Series
Accession:
GSE20950
ID:
200020950
5.
Full record GDS3781

Morbidly obese insulin-resistant patients: omental and subcutaneous adipose tissue

Analysis of subcutaneous and visceral adipose tissue from body mass index (BMI)-matched, obese patients who were insulin-sensitive versus insulin-resistant, thereby eliminating obesity as a variable. Results provide insight into molecular mechanisms mediating obesity-related insulin resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 gender, 2 tissue sets
Platform:
GPL570
Series:
GSE20950
39 Samples
Download data: CEL
6.

Remodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation

(Submitter supplied) The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription program of mitochondrial biogenesis and thermogenesis. In the present study, we evaluated the role of NT-PGC-1α in brown adipocyte energy metabolism by genome-wide profiling of NT-PGC-1α-responsive genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2995
4 Samples
Download data: TXT
Series
Accession:
GSE71774
ID:
200071774
7.

Expression data from SGBS human cells before and after 24 hours of stimulation with differentiation cocktail, with or without Scrambled (Scr) or Tenomodulin (TNMD) siRNA to knockdown the genes of interest.

(Submitter supplied) In a screen for upregulated adipocyte genes in insulin resistant versus insulin sensitive subjects matched for BMI, we identified the type II transmembrane protein tenomodulin (TNMD), previously implicated in glucose tolerance in gene association studies. TNMD expression was greatly increased in human preadipocytes during differentiation, while silencing TNMD blocked adipogenic gene induction and adipogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
12 Samples
Download data: CEL
Series
Accession:
GSE76319
ID:
200076319
8.

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

(Submitter supplied) Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2123
Platform:
GPL1261
6 Samples
Download data
Series
Accession:
GSE5042
ID:
200005042
9.

Expression of the brown fat thermogenic gene program requires PGC-1alpha

(Submitter supplied) To investigate the specific role of PGC-1 coactivators in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1alpha. We could then efficiently knockdown PGC-1beta expression by shRNA expression. Loss of PGC-1alpha did not alter brown fat differentiation but severly reduced the induction of thermogenic genes. In order to assess the specific requirement for PGC-1α in the global transcriptional response to cAMP, we used Affymetrix arrays to compare the sets of genes induced in response to a 4 hr dbcAMP treatment in differentiated wt and KO cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2149
Platform:
GPL1261
8 Samples
Download data
Series
Accession:
GSE5041
ID:
200005041
10.
Full record GDS2149

PGC-1alpha null brown adipocyte response to cAMP

Analysis of PGC-1alpha null brown adipocytes treated with cAMP for 4 hours. PGC-1alpha is required for the thermogenic function of brown fat cells, and cAMP plays a role in thermogenesis. Results provide insight into the role of PGC-1alpha in the global transcriptional response to cAMP.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5041
8 Samples
Download data
DataSet
Accession:
GDS2149
ID:
2149
11.
Full record GDS2123

Brown fat cell response to PGC-1alpha and PGC-1beta deficiency

Analysis of brown fat cells lacking PGC-1alpha or both PGC-1alpha and PGC-1beta. PGC-1alpha is required for the thermogenic function of brown fat cells, and PGC-1beta is the closest homolog of PGC-1alpha. Results provide insight into the specific roles of PGC-1alpha and PGC-1beta in brown fat cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE5042
6 Samples
Download data
DataSet
Accession:
GDS2123
ID:
2123
12.

Gene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes

(Submitter supplied) Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4851
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE40280
ID:
200040280
13.
Full record GDS4851

TRPV4 depletion effect on adipocyte cell line

Analysis of 3T3-F442A adipocytes depleted for transient receptor potential vanilloid 4 (TRPV4). TRPV4 is a cation channel. Results provide insight into the function of TRPV4 in adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL8321
Series:
GSE40280
4 Samples
Download data: CEL
14.

Regulation of gene expression program by Fsp27 in white and brown adipose tissue

(Submitter supplied) Background: Brown and white adipose tissues (BAT and WAT) play critical roles in controlling energy homeostasis and in the development of obesity and diabetes. Fsp27 is expressed in both BAT and WAT and promotes lipid storage and the development of obesity and diabetes. In addition, Fsp27-deficient white adipocytes acquired certain BAT-like properties including reduced lipid droplet size and increased mitochondrial activity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3768
Platform:
GPL339
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE22693
ID:
200022693
15.
Full record GDS3768

Fat-Specific protein 27 knockout effect on white adipose tissue

Analysis of gonadal white adipose tissue (WAT) from Fat-Specific protein 27 (FSP27)-null males. FSP27-null WATs have reduced lipid storage, smaller lipid droplets, and increased mitochondrial activity. Results provide insight into molecular mechanisms by which FSP27 controls lipid storage in WAT.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE22693
4 Samples
Download data: CEL, CHP
16.

Human subcutaneous adipose tissue and perithyroid adipose tissue gene expression

(Submitter supplied) Different human adipose tissue depots may have functional differences. Subcutaneous human adipose tissue has been extensively studied, but less is known about other depots. Perithyroid (PT) adipose tissue contains not only white adipocytes but also brown adipocytes. The aim of this study was to compare the expression of brown adipocyte containing perithyroid adipose tissue with s.c. adipose tissue.role in the development of obesity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE27657
ID:
200027657
17.

Gene expression profiles reveal the effect of a high-fat diet in brown fat development

(Submitter supplied) Genome-scale analysis of the genetic factors that govern the development of white and brown adipose tissue is still far from complete. In order to identify the key genes that regulate the development of white and brown adipose tissue in mice, the transcriptome analysis was performed on adipose tissues
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS6000
Platform:
GPL6887
33 Samples
Download data: TXT
Series
Accession:
GSE64718
ID:
200064718
18.
Full record GDS6000

High-fat diet effect on brown adipose tissue development

Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 6 time sets
Platform:
GPL6887
Series:
GSE64718
33 Samples
Download data
DataSet
Accession:
GDS6000
ID:
6000
19.

Effect of forced uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression

(Submitter supplied) The aim of this study was to investigate the molecular basis underlying the response of 3T3-L1 adipocytes to forced expression of UCP1. Keywords: adipocyte, Uncoupling protein 1, microarray
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2897
6 Samples
Download data
Series
Accession:
GSE6643
ID:
200006643
20.

Gene Expression in the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice

(Submitter supplied) ob/ob mice is an obese mice. CIDE family proteins including Cidea, Cideb and Cidec play important role in lipid metabolism. Cidea is mainly expressed in the brown adipose tissue (BAT). Cidec is mainly expressed in the BAT and white adipose tissue (WAT). We generated ob/ob/Cidea-/-/Cidec-/- mice to investigate the phenotype of fat tissue. ob/ob/Cidea-/-/Cidec-/- mice are lean when compared with ob/ob mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL, XLSX
Series
Accession:
GSE100989
ID:
200100989
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