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Links from GEO DataSets

Items: 4

1.

Microarray profiling of expression patterns of fibroblasts from different skin types

(Submitter supplied) Adult human fibroblasts derived from the dermis of 4 mm punch biopsies taken from the lower backs of 15 healthy subjects of 3 different phototypes (types I, III and VI). This study was approved by the Human Research Ethics Committee of Hamburg. Subjects with type I skin were #4, 12, 15, 19 and 26; subjects with type III skin were # 6, 9, 13, 14 and 23, and subjects with type VI skin were # 7, 8, 16, 17 and 28. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3779
15 Samples
Download data: GPR
Series
Accession:
GSE22022
ID:
200022022
2.

Regulation of human skin pigmentation in situ by repetitive UV exposure - Molecular characterization of responses to UVA, UVB and SSR

(Submitter supplied) To test the hypothesis that different mechanisms and/or factors might be involved in physiological pigmentary responses of the skin to different types of UV, we used whole human genome microarrays and immunohistochemical analyses to characterize human skin in situ to examine how melanocyte-specific proteins and paracrine melanogenic factors are regulated by repetitive exposure to suberythemal doses of different types of UV (UVA, UVB or SSR).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
24 Samples
Download data: TXT, XLS
Series
Accession:
GSE21429
ID:
200021429
3.

Effects of DKK1 on gene expression on keratinocytes

(Submitter supplied) Dickkopf 1 (DKK1), which is expressed at high mRNA levels by fibroblasts in the dermis of human skin on the palms and soles, inhibits the function and proliferation of melanocytes in the epidermis of those areas via the suppression of beta-catenin and microphthalmia-associated transcriptor factor (MITF). In this study, we report that treatment of keratinocytes with DKK1 increases their proliferation and decreases their uptake of melanin, and that treatment of reconstructed skin with DKK1 induces a thicker and less pigmented epidermis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1528
6 Samples
Download data: TXT
Series
Accession:
GSE9211
ID:
200009211
4.

Microarray analysis of genes impacted by 5 day knockdown of SLC24A5 in normal human melanocytes.

(Submitter supplied) A major development in pigmentation research was the discovery of the involvement of SLC24A5 in natural variation in skin colour. This study used Agilent whole-genome microarrays to examine the impact of SLC24A5 knockdown on the transcriptome of normal human melanocytes derived from lightly and darkly pigmented donors.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
30 Samples
Download data: TXT
Series
Accession:
GSE21565
ID:
200021565
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