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Links from GEO DataSets

Items: 20

1.

Gene expression profile of the SV40-immortalized human corneal epithelial cells

(Submitter supplied) Microarray was used to study global gene expression of a cell culture model based on SV40-immortalized human corneal epithelial (iHCE) cells. The gene expression profile of the cell line was compared to the normal human corneal epithelium. Affymetrix HG-U133A GeneChips® were used for microarray experiments and results were validated by performing RT-qPCR for selected genes. iHCE was found to over- and under-express 22 % and 14 % of the annotated genes, respectively. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
3 Samples
Download data: CEL
Series
Accession:
GSE22539
ID:
200022539
2.

Molecular profiling of the of conjunctival epithelial side population cells

(Submitter supplied) Side population (SP) cells isolated from limbal and conjunctival epithelia derive from cells that are slow cycling in vivo, a known feature of tissue stem cells. The purpose of this study was to define the molecular signature of the conjunctival side population cells by global differential gene expression to identify markers and signaling pathways associated with this cell phenotype. Four overnight cultures of freshly isolated human conjunctival epithelial cells stained with Hoechst 3342 were cytometrically sorted into SP and non-SP cohorts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE12631
ID:
200012631
3.

Gene Expression in Human Conjunctiva and Cornea

(Submitter supplied) PURPOSE. To determine global mRNA expression levels in the corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS. cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide array representing > 22,000 transcripts. The resulting signal intensities and transcript present/absent calls by the primary microarray analyzing software were used in conjunction with a statistical method to identify transcripts that are preferentially or exclusively (transcripts absent in all three replicates in the other tissue) and significantly (expression >1% of the ß-actin level) expressed in one of the two tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2682
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE5543
ID:
200005543
4.
Full record GDS2682

Conjunctiva and cornea comparison

Analysis of conjunctival (Cnj) and corneal (Co) epithelia, the main cellular components of the ocular surface. Cnj and Co epithelia are embryologically related but phenotypically and functionally disparate. Results provide insight into the molecular basis of these differences.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE5543
6 Samples
Download data
5.

Influence of Sex on Gene Expression in Human Corneal Epithelial Cells

(Submitter supplied) Objectives. Sex-associated differences have been identified in the anatomy, physiology and pathophysiology of the human cornea. We hypothesize that many of these differences are due to fundamental variations in gene expression. Our objective in this study was to determine whether such differences do exist in human corneal epithelial cells both in vivo and in vitro. Methods. Human corneal epithelial cells were isolated from the corneoscleral rims of male and female donors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL8159 GPL571 GPL8158
16 Samples
Download data: XLS
Series
Accession:
GSE14621
ID:
200014621
6.

Lens Epithelial Cells and Lens Cortical Fiber Cells

(Submitter supplied) Total RNA was isolated from three separate populations of human lens epithelial cells and three matching populations of lens cortical fiber cells. All samples were analyzed on separate microarrays. Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1327
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE2256
ID:
200002256
7.
Full record GDS1327

Lens epithelial and lens cortical fiber cell comparison

Comparison of lens epithelial cells to lens cortical fiber cells. Cells microdissected from lenses of post mortem donors. Results identify genes that may play roles in maintaining the specialized functions of each cell type and provides insight into potential mechanisms of lens cell differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE2256
6 Samples
Download data
8.

Human bronchial epithelial cell differentiation time course

(Submitter supplied) Microarray analysis was performed to identify transcriptional changes that occur during mucociliary differentiation of human primary bronchial epithelial cells cultured at an air-liquid interface (ALI). Keywords: time course
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2615
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE5264
ID:
200005264
9.
Full record GDS2615

Mucociliary differentiation of airway epithelial cells

Analysis of primary airway epithelial cells cultured at an air-liquid interface for up to 28 days to induce their differentiation into polarized, pseudostratified epithelia of ciliated and mucus-secreting cells. Results provide insight into the mechanisms underlying mucociliary differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 individual, 11 time sets
Platform:
GPL570
Series:
GSE5264
30 Samples
Download data: CEL
DataSet
Accession:
GDS2615
ID:
2615
10.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
11.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
12.

RNAseq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells

(Submitter supplied) The specialized corneal epithelium requires differentiated properties, specific for its role at the anterior surface of the eye, thus tight maintenance of the differentiated qualities of the corneal epithelial is essential. Our studies have focused on pinin (PNN), an exon junction component (EJC) that has dramatic implications on corneal epithelial cell differentiation and may act as a stabilizer of the corneal epithelial cell phenotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
32 Samples
Download data: XLSX
Series
Accession:
GSE73060
ID:
200073060
13.

Comparative transcriptional profiling of Limbal Epithelial Crypts with rest of the ocular surface epithelial regions.

(Submitter supplied) Recently we had discovered a solid cord like structure at the limbus of human eyes, termed as the Limbal Epithelial Crypt (LEC). It arises from the undersurface of the interpalisade rete ridges and extends towards the conjunctiva over the conjunctival stroma. Anatomical and immunohistochemical studies have shown it to be potentially a Stem Cell Niche. To confirm this hypothesis we conducted comparative gene expression profile of LEC with pathway and Geneontology studies in comparison with other ocular surface epithelial regions such as cornea, limbus, LEC stroma and conjunctiva. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9677
18 Samples
Download data: GPR
Series
Accession:
GSE19035
ID:
200019035
14.

Gene expression profiles of LEC, MLC-L, and MSC-BM

(Submitter supplied) Gene expression profiles of limbal explant culture-derived epithelial (LEC) and mesenchymal-like cells (MLC-L) and bone marrow-derived mesenchymal stem cells (MSC-BM). To confirm the stem cell signatures of cultured LEC and to establish the source, possible role of the stroma-derived MLC-L .
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
6 Samples
Download data: TXT
Series
Accession:
GSE16763
ID:
200016763
15.

Transcriptional profiles along cell programming into corneal epithelial differentiation

(Submitter supplied) Corneal epithelial RCE1(5T5) cells follow a sequential process that leads to the formation of a 4-5 layered stratified epithelium with a gene expression pattern similar to that shown in primary cultures of corneal epithelial cells. We have identified three different developmental stages during the differentiation of the rabbit corneal epithelial cell line RCE1(5T5), and thus, analyzed the transcriptome of such different stages in order to understand the regulation of the corneal epithelial cell differentiation. more...
Organism:
Oryctolagus cuniculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16405
3 Samples
Download data: TXT
Series
Accession:
GSE147779
ID:
200147779
16.

Transcriptomic and gene ontology profiling of the human corneal cell types

(Submitter supplied) Purpose: To identify distinct gene expression and functional profiles for the three main cell types (epithelial, keratocyte and endothelial) of the human cornea. Methods: RNA-sequencing was performed using total RNA isolated from ex vivo corneal epithelial cells (evCEpC), keratocytes (evK) and endothelial cells (evCEnC) obtained from 3 donor corneas obtained from a commercial eye bank. Transcriptomic analysis was performed using Kallisto (alignment (hg38) and quantification) and Sleuth (differential gene expression(DGE)), with transcript abundances calculated as transcripts per kilobase million (TPM). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
9 Samples
Download data: TXT
Series
Accession:
GSE121922
ID:
200121922
17.

Transcriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy

(Submitter supplied) The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for alternative sources of transplantable tissue. Cultured human corneal endothelial cells (HCEnC) have been shown to restore corneal clarity in experimental models of corneal endothelial dysfunction in animal models, but characterization of cultured HCEnC remains incomplete. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
15 Samples
Download data: TXT
Series
Accession:
GSE65991
ID:
200065991
18.

Dihydrotestosterone induced changes in gene expression in immortalized human conjunctival epithelial cells

(Submitter supplied) Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in immortalized human conjunctival epithelial cells. Analysis of regulation of immortalized human conjunctival epithelial cells by dihydrotestosterone at gene expression level. The hypothesis tested in the present study was that the androgen-eye interaction in ocular surface epithelial cells like conjunctival cells is influenced by androgens through regulation of the expression of multiple genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE18094
ID:
200018094
19.

Dihydrotestosterone induced changes in gene expression in immortalized human meibomian gland epithelial cells

(Submitter supplied) Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in immortalized human meibomian gland epithelial cells. Analysis of regulation of immortalized human meibomian gland epithelial cells by dihydrotestosterone at gene expression level. The hypothesis tested in the present study was that the androgen-eye interaction in ocular surface epithelial cells like meibomian gland cells is influenced by androgens through regulation of the expression of multiple genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE18091
ID:
200018091
20.

Gene expression in a 3-dimensional reconstructed human corneal epithelial tissue after near-infrared irradiation simulating solar near-infrared radiation that reaches human tissues on the Earth’s surface

(Submitter supplied) To clarify the effects of near-infrared radiation, we assessed DNA microarray after water-filtered broad-spectrum near-infrared (1100-1800 nm together with a water-filter that excludes wavelengths 1400-1500 nm) irradiation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
4 Samples
Download data: TXT
Series
Accession:
GSE76500
ID:
200076500
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